431 Result(s)
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Article
Biotechnology in China: Walking on Two Legs
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Article
Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery
We have characterized the relationships between the design of cationic liposomes as a gene transfer vehicle, their resulting biodistribution and processing in animals, and the level and sites of gene expressio...
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Article
The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold
The first structure of an aldehyde dehydrogenase (ALDH) is described at 2.6 Å resolution. Each subunit of the dimeric enzyme contains an NAD-binding domain, a catalytic domain and a bridging domain. At the int...
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Article
Synthesis and antimutagenic effects of selena-morpholine hydrate
The synthesis of selenamorpholine hydrate was described and its antimutagenic effects were investigated by the Ames tests. The results indicated that the mutation induced by the indirect mutagen 2-AF was inhib...
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Article
Analysis of characteristic of aurora substorm observed at Antarctic Zhongshan station
The characteristics of a strong aurora substorm observed at Antarctic Zhongshan station (magnetic latitude=74.5°) on 8 April, 1999, were discussed and analyzed. The develo** steps of the aurora substorm that...
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Article
Ground observations of post-noon aurora: a case study
The characteristics of the post-noon aurora observed at Antarctic Zhongshan station on June 12, 1999, were discussed and analyzed. In the condition of the magnetic activity is not large (K p≈1), f...
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Article
Locating the polar cap boundary of postnoon sector from observations of 630.0 nm auroral emission at Zhongshan Station
We studied the ground observations of 630.0 nm auroral emission at Zhongshan Station to determine the polar cap boundary with the latitudinal profile of emission intensity. The open-closed field time boundary ...
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Article
Cloning and characterization of a mouse liver-specific gene mfrep-1, upregulated in liver regeneration
Human fibrinogen-related protein-1/liver fibrinogen-related protein-1 (HFREP-1/LFIRE-1), a liver-specific protein, is a member of fibrinogen superfamily that exerts various biological activities. However, the ...
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Article
From designing a single neural network to designing neural network ensembles
This paper introduces supervised learning model, and surveys related research work. The paper is organised as follows. A supervised learning model is firstly described. The bias-variance trade-off is then disc...
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Article
Analysis of negative correlation learning
This paper describes negative correlation learning for designing neural network ensembles. Negative correlation learning has been firstly analysed in terms of minimising mutual information on a regression task...
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Article
Quantum chemical study of the leveling property of organic additives for Ni electroplating
The geometries of the molecules of eight organic additives were optimized and the net charge,E HOMO andE LUMO were obtained using AM method, respectively. The result shows that the...
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Article
Embryonic stem cells generated by nuclear transfer of human somatic nuclei into rabbit oocytes
To solve the problem of immune incompatibility, nuclear transplantation has been envisaged as a means to produce cells or tissues for human autologous transplantation. Here we have derived embryonic stem cells...
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Article
Effect of iron deficiency on heterocyst differentiation and physiology of the filamentous cyanobacteriumAnabaena sp. PCC 7120
The effect of iron deficiency on heterocyst differentiation and some physiological properties of the filamentous cyanobacteriumAnabaena sp. PCC 7120 was investigated. Under moderate iron limitation conditions, ac...
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Article
Arabidopsis RAV1 is down-regulated by brassinosteroid and may act as a negative regulator during plant development
RAV1 is a novel DNA-binding protein with two distinct DNA-binding domains unique in higher plants, but its role in plant growth and development remains unknown. Using cDNA array, we found that transcription of RA...
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Article
Open AccessCurrent limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis
Public SNP databases are frequently used to choose SNPs for candidate genes in the association and linkage studies of complex disorders. However, their utility for such studies of diseases with ethnic-dependen...
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Open AccessPatterns of linkage disequilibrium and haplotype distribution in disease candidate genes
The adequacy of association studies for complex diseases depends critically on the existence of linkage disequilibrium (LD) between functional alleles and surrounding SNP markers.
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Article
Cloning and characterization of thefecC gene necessary for optimal growth under iron-deficiency conditions in the cyanobacteriumAnabaena sp. PCC 7120
ThefecC gene encoding a putative iron (III) dicitrate transporter was cloned from nitrogen-fixing cyanobacteriumAnabaena sp. PCC 7120, and inactivated. The mutant grows normally in medium with NO ...
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Article
Injector nozzle flow model and its effects on the calculations of high pressure sprays
This paper discusses the flowing process inside a nozzle, especially the formation mechanism of cavitations within the nozzle and puts forward a nozzle flow model, which takes account of the injection conditio...
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Article
Regulations of thyroid hormone on cardiac protein kinase C signal pathwayin vitro
The experiments were conducted to assess the influences of thyroid hormone on cardiac protein kinase C(PKC) signal pathway with cultured cardiac myocytes and fibroblasts as the models. Cells were pretreated wi...
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Article
The synthesis of a fluorescent chemosensor containing two thiourea groups and its recognition behavior for dicarboxylate anions
A novel anion receptor2 bearing anthracene flurophore and thiourea was synthesized and identified by1H NMR, MS, IR and elemental analysis. The interaction between receptor2 and various α, ω-dicarboxylate anions w...
