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Article
Open AccessThe influence of sex-specific factors on biological transformations and health outcomes in aging processes
The aging process demonstrates notable differences between males and females, which are key factors in disease susceptibility and lifespan. The differences in sex chromosomes are fundamental to the presence of...
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Article
Open AccessA novel LGALS1-depended and immune-associated fatty acid metabolism risk model in acute myeloid leukemia stem cells
Leukemia stem cells (LSCs) are recognized as the root cause of leukemia initiation, relapse, and drug resistance. Lipid species are highly abundant and essential component of human cells, which often changed i...
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Article
Open AccessThe role of lncRNA NEAT1 in human cancer chemoresistance
Chemotherapy is currently one of the most effective methods in clinical cancer treatment. However, chemotherapy resistance is an important reason for poor chemotherapy efficacy and prognosis, which has become ...
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Article
Open AccessMarangoni-driven deterministic formation of softer, hollow microstructures for sensitivity-enhanced tactile system
Microengineering the dielectric layers with three-dimensional microstructures has proven effective in enhancing the sensitivity of flexible pressure sensors. However, the widely employed geometrical designs of...
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Article
Open AccessModel inductive bias enhanced deep reinforcement learning for robot navigation in crowded environments
Navigating mobile robots in crowded environments poses a significant challenge and is essential for the coexistence of robots and humans in future intelligent societies. As a pragmatic data-driven approach, de...
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Article
Open AccessDG2GAN: improving defect recognition performance with generated defect image sample
This article aims to improve the deep-learning-based surface defect recognition. In actual manufacturing processes, there are issues such as data imbalance, insufficient diversity, and poor quality of augmente...
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Article
Open AccessCentral imaging based on near-infrared functional imaging technology can be useful to plan management in patients with chronic lateral ankle instability
Near infrared brain functional imaging (FNIRS) has been used for the evaluation of brain functional areas, the imaging differences of central activation of cognitive-motor dual tasks between patients with chro...
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Open AccessCorrection: Qualitative assessment of optimizing the well spacings based on the economic analysis
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Open AccessTrends and age-period-cohort effect on incidence of hepatitis B from 2008 to 2022 in Guangzhou, China
Hepatitis B virus (HBV) infection is highly prevalent in Guangzhou, China. This study aimed to examine the long-term trend of HB incidence from 2008 to 2022 and the independent impacts of age, period, and coho...
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Article
Open AccessThe Masquelet induced membrane technique with PRP-FG-nHA/PA66 scaffold can heal a rat large femoral bone defect
Masquelet membrane induction technology is one of the treatment strategies for large bone defect (LBD). However, the angiogenesis ability of induced membrane decreases with time and autologous bone grafting is...
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Article
Open AccessWhole-genome sequencing reveals genomic diversity and selection signatures in **a’nan cattle
The crossbreeding of specialized beef cattle breeds with Chinese indigenous cattle is a common method of genetic improvement. **a’nan cattle, a crossbreed of Charolais and Nanyang cattle, is China’s first spec...
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Open AccessRelationship between jejunum ATPase activity and antioxidant function on the growth performance, feed conversion efficiency, and jejunum microbiota in Hu sheep (Ovis aries)
ATPase activity and the antioxidant function of intestinal tissue can reflect intestinal cell metabolic activity and oxidative damage, which might be related to intestinal function. However, the specific influ...
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Article
Open AccessHsa_circ_0004872 mitigates proliferation, metastasis and immune escape of meningioma cells by suppressing PD-L1
Meningioma is a prevalent intracranial malignancy known for its aggressive growth. Circular RNAs (circRNAs) play a crucial role in the development of various cancers. However, their involvement in meningioma r...
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Open AccessSimilar but yet different: individual cognitive traits and family contingencies as antecedents of intrapreneurship and self-employment
Entrepreneurship is of great significance to individuals, families and society. Recently, intrapreneurship, i.e., business ventures within established organisations, has also attracted widespread interest amon...
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Article
Open AccessQualitative assessment of optimizing the well spacings based on the economic analysis
The design of well spacing significantly influences the sustainability and economic benefit of geothermal energy extraction. However, most studies have predominantly employed heat production-related parameters...
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Article
Open AccessGroup 2i Isochrysidales thrive in marine and lacustrine systems with ice cover
Global warming is causing rapid changes to the cryosphere. Predicting the future trajectory of the cryosphere requires quantitative reconstruction of its past variations. A recently identified sea-ice-associat...
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Open AccessMechanically robust and personalized silk fibroin-magnesium composite scaffolds with water-responsive shape-memory for irregular bone regeneration
The regeneration of critical-size bone defects, especially those with irregular shapes, remains a clinical challenge. Various biomaterials have been developed to enhance bone regeneration, but the limitations ...
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Article
Open AccessClinical and genetic analysis of methylmalonic aciduria in 60 patients from Southern China: a single center retrospective study
Methylmalonic aciduria (MMA) is a group of rare genetic metabolic disorders resulting from defects in methylmalonyl coenzyme A mutase (MCM) or intracellular cobalamin (cbl) metabolism. MMA patients show divers...
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Open AccessNext-generation sequencing identified that RET variation associates with lymph node metastasis and the immune microenvironment in thyroid papillary carcinoma
To date, although most thyroid carcinoma (THCA) achieves an excellent prognosis, some patients experience a rapid progression episode, even with differentiated THCA. Nodal metastasis is an unfavorable predicto...
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Open AccessMicroinvasion in hepatocellular carcinoma: predictive factor and application for definition of clinical target volume for radiotherapy
To investigate the correlation between microinvasion and various features of hepatocellular carcinoma (HCC), and to clarify the microinvasion distance from visible HCC lesions to subclinical lesions, so as to ...
