67 Result(s)

Article

A novel LGALS1-depended and immune-associated fatty acid metabolism risk model in acute myeloid leukemia stem cells

Leukemia stem cells (LSCs) are recognized as the root cause of leukemia initiation, relapse, and drug resistance. Lipid species are highly abundant and essential component of human cells, which often changed i...

Huanhuan Qin, Meixi Peng, **gsong Cheng, Zhenyu Wang, Yinghui Cui… in Cell Death & Disease (2024)

Article

Whole-genome sequencing reveals genomic diversity and selection signatures in **a’nan cattle

The crossbreeding of specialized beef cattle breeds with Chinese indigenous cattle is a common method of genetic improvement. **a’nan cattle, a crossbreed of Charolais and Nanyang cattle, is China’s first spec...

**ngya Song, Zhi Yao, Zi**g Zhang, Shijie Lyu, Ningbo Chen, **ngshan Qi… in BMC Genomics (2024)

Article

Castration alters the ileum microbiota of Holstein bulls and promotes beef flavor compounds

In the beef industry, bull calves are usually castrated to improve flavor and meat quality; however, this can reduce their growth and slaughter performance. The gut microbiota is known to exert a significant i...

**** Shi, Zemin Li, Li Jia, Yue Ma, Yongliang Huang, Pengjia He, Tao Ran… in BMC Genomics (2024)

Article

Correction: Transcriptomics and metabolomics of blood, urine and ovarian follicular fuid of yak at induced estrus stage

Huangqing Zhao, Yongzhen Huang, Shi Shu, Guowen Wang, Changqi Fu… in BMC Genomics (2024)

Article

Transcriptomics and metabolomics of blood, urine and ovarian follicular fluid of yak at induced estrus stage

To gain a deeper understanding of the metabolic differences within and outside the body, as well as changes in transcription levels following estrus in yaks, we conducted transcriptome and metabolome analyses ...

Huangqing Zhao, Yongzhen Huang, Shi Shu, Guowen Wang, Changqi Fu… in BMC Genomics (2024)

Article

Development of a coding SNP panel for tracking the origin of whole-exome sequencing samples

Whole-exome sequencing (WES) is widely used to diagnose complex genetic diseases and rare conditions. The implementation of a robust and effective quality control system for sample identification and tracking ...

Yong Huang, Yuanyuan **ao, Shengqiu Qu, Jiaming Xue, Lin Zhang, Li Wang… in BMC Genomics (2024)

Article

N6-methyladenosine demethylase FTO regulates synaptic and cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal rats

Hypoxic-ischemic brain damage (HIBD) can result in significant global rates of neonatal death or permanent neurological disability. N6-methyladenosine (m6A) modification of RNA influences fundamental aspects o...

Jianhui Deng, Yanling Liao, Jianghu Chen, Andi Chen, Shuyan Wu… in Cell Death & Disease (2023)

Article

Selective activation of AKAP150/TRPV1 in ventrolateral periaqueductal gray GABAergic neurons facilitates conditioned place aversion in male mice

Aversion refers to feelings of strong dislike or avoidance toward particular stimuli or situations. Aversion can be caused by pain stimuli and has a long-term negative impact on physical and mental health. Ave...

**aohui Bai, Kun Zhang, Chaopeng Ou, Bilin Nie, Jianxing Zhang… in Communications Biology (2023)

Article

Genetic diversity and signatures of selection in BoHuai goat revealed by whole-genome sequencing

Cross breeding is an important way to improve livestock performance. As an important livestock and poultry resource in Henan Province of China, Bohuai goat was formed by crossing Boer goat and Huai goat. After...

Zhi Yao, Shun** Zhang, **anwei Wang, Yingwei Guo, **aoling **n… in BMC Genomics (2023)

Article

Ferroptosis, pyroptosis and necroptosis in acute respiratory distress syndrome

Acute respiratory distress syndrome (ARDS) is an acute and uncontrolled pulmonary inflammation caused by various insults. Cell death is a critical mechanism in the pathogenesis of ARDS. Ferroptosis, a novel fo...

Yongxin Zheng, Yongbo Huang, Yonghao Xu, Ling Sang, **aoqing Liu… in Cell Death Discovery (2023)

Article

MIIP functions as a novel ligand for ITGB3 to inhibit angiogenesis and tumorigenesis of triple-negative breast cancer

Migration and invasion inhibitory protein (MIIP) has been identified as a tumor suppressor in various cancer types. Although MIIP is reported to exert tumor suppressive functions by repressing proliferation an...

Yu**g Gao, Yujie Fang, Yongli Huang, Rui Ma, **xi Chen, Fang Wang… in Cell Death & Disease (2022)

Article

Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression

Prostate cancer (PCa) is a malignant tumor that seriously threatens men’s health worldwide. Recently, stromal cells in the tumor microenvironment (TME) have been reported to contribute to the progression of PC...

Tianqi Wu, Wenfeng Wang, Guohai Shi, Mingang Hao, Yingying Wang… in Cell Death & Disease (2022)

Article

Transcriptomic analysis of tuberous root in two sweet potato varieties reveals the important genes and regulatory pathways in tuberous root development

Tuberous root formation and development is a complex process in sweet potato, which is regulated by multiple genes and environmental factors. However, the regulatory mechanism of tuberous root development is u...

Zhaoqin Cai, Zhipeng Cai, **gli Huang, Aiqin Wang, Aaron Ntambiyukuri… in BMC Genomics (2022)

Article

Identification of hub genes and pathways in colitis-associated colon cancer by integrated bioinformatic analysis

Colitis-associated colon cancer (CAC) patients have a younger age of onset, more multiple lesions and invasive tumors than sporadic colon cancer patients. Early detection of CAC using endoscopy is challenging,...

Yongming Huang, **aoyuan Zhang, PengWang, Yansen Li, Jie Yao in BMC Genomic Data (2022)

Article

Assessing genomic diversity and signatures of selection in Pinan cattle using whole-genome sequencing data

Crossbreeding is an important way to improve production beef cattle performance. Pinan cattle is a new hybrid cattle obtained from crossing Piedmontese bulls with Nanyang cows. After more than 30 years of cros...

Shun** Zhang, Zhi Yao, **nmiao Li, Zi**g Zhang, **an Liu, Peng Yang… in BMC Genomics (2022)

Article

PHF13 epigenetically activates TGFβ driven epithelial to mesenchymal transition

Epigenetic alteration is a pivotal factor in tumor metastasis. PHD finger protein 13 (PHF13) is a recently identified epigenetic reader of H3K4me2/3 that functions as a transcriptional co-regulator. In this st...

Yating Sun, Dan Li, Hongmei Liu, Yongye Huang, Fanyu Meng… in Cell Death & Disease (2022)

Article

RNF12 is regulated by AKT phosphorylation and promotes TGF-β driven breast cancer metastasis

Transforming growth factor-β (TGF-β) acts as a pro-metastatic factor in advanced breast cancer. RNF12, an E3 ubiquitin ligase, stimulates TGF-β signaling by binding to the inhibitory SMAD7 and inducing its pro...

Yongsheng Huang, Sijia Liu, Mengjie Shan, Sophie C. Hagenaars… in Cell Death & Disease (2022)

Article

LncRNA RP11-89 facilitates tumorigenesis and ferroptosis resistance through PROM2-activated iron export by sponging miR-129-5p in bladder cancer

Long non-coding RNAs (lncRNAs) act as important regulators of tumorigenesis and development in bladder cancer. However, the underlying molecular mechanisms remain elusive. We previously identified a novel lncR...

Wenjie Luo, Jun Wang, Wenhao Xu, Chunguang Ma, Fangning Wan… in Cell Death & Disease (2021)

Article

GIPC2 is an endocrine-specific tumor suppressor gene for both sporadic and hereditary tumors of RET- and SDHB-, but not VHL-associated clusters of pheochromocytoma/paraganglioma

Pheochromocytoma/paraganglioma (PPGL) is an endocrine tumor of the chromaffin cells in the adrenal medulla or the paraganglia. Currently, about 70% of PPGLs can be explained by germline or somatic mutations in...

Yeqing Dong, Yongsheng Huang, Chengyan Fan, Liang Wang, Ran Zhang… in Cell Death & Disease (2021)

Article

Transcriptome-wide study revealed m6A regulation of embryonic muscle development in Dingan goose (Anser cygnoides orientalis)

The number of myofiber is determined during the embryonic stage and does not increase during the postnatal period for birds, including goose. Thus, muscle production of adult goose is pre-determined during emb...

Tieshan Xu, Zijie Xu, Lizhi Lu, Tao Zeng, Lihong Gu, Yongzhen Huang… in BMC Genomics (2021)