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Article
Open AccessABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway
The development of resistance to anticancer drugs is believed to cause chemotherapy failure in pancreatic cancer (PC). The efflux of anticancer drugs mediated by ATP-binding cassette (ABC) transporters is a wi...
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Article
Open AccessCOL4A1 promotes the growth and metastasis of hepatocellular carcinoma cells by activating FAK-Src signaling
Collagens are the most abundant proteins in extra cellular matrix and important components of tumor microenvironment. Recent studies have showed that aberrant expression of collagens can influence tumor cell b...
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Article
Open AccessCircular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs
Circular RNAs (circRNAs) represent a class of widespread and diverse endogenous RNAs that may regulate gene expression in eukaryotes. However, the regulation and function of human circRNAs remain largely unkno...
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Article
Open AccessHERC5 is a prognostic biomarker for post-liver transplant recurrent human hepatocellular carcinoma
Orthotopic liver transplantation (OLT) can be an effective treatment option for certain patients with early stage hepatocellular carcinoma (HCC) meeting Milan, UCSF, or Hangzhou criteria. However, HCC recurren...
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Article
Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis
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Article
Open AccessEnriched Environment Inhibits Mouse Pancreatic Cancer Growth and Down-regulates the Expression of Mitochondria-related Genes in Cancer Cells
Psycho-social stress has been suggested to influence the development of cancer, but it remains poorly defined with regard to pancreatic cancer, a lethal malignancy with few effective treatment modalities. In t...
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Article
An EpCAM/CD3 bispecific antibody efficiently eliminates hepatocellular carcinoma cells with limited galectin-1 expression
There have been several studies suggesting that cancer stem cells (CSCs) contribute to the high rates of recurrence and resistance to therapies observed in hepatocellular carcinoma (HCC). Epithelial cell adhes...
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Article
Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma
We have previously identified 1 241 regions of somatic copy number alterations (CNAs) in hepatocellular carcinoma (HCC). In the present study, we found that a novel recurrent focal amplicon, 1q24.1-24.2, targe...
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Article
Open AccessApplication of microRNA and mRNA expression profiling on prognostic biomarker discovery for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most highly malignant and lethal cancers of the world. Its pathogenesis has been reported to be multi-factorial, and the molecular carcinogenesis of HCC can not be ...
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Chapter
Concepts, Challenges and Perspectives in Cancer Research
Cancer is one of the most fatal diseases in the world. It caused almost 12% of all deaths in women and 14% in men in 2004, only next to cardiovascular diseases, infectious and parasitic diseases. After a centu...
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Chapter
Cancer Stem Cells of Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the most aggressive cancers with a poor prognosis. HCC is suggested to originate from the malignant transformation of liver-resident stem/progenitor cells. HCC cancer s...
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Chapter
Systemic Dysregulation in the Development of Hepatocellular Carcinoma
Cancer is an ancient disease of multi-cellular organisms acquired in the history of evolution. For more than one century, cancer was defined as a disease of autonomous, abnormal growth of cells from an organ o...
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Article
Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA
Twenty-two microRNAs are found to be amplified or deleted in hepatocellular carcinoma (HCC). miR-151 is encoded by an intron in the focal adhesion kinase FAK-1 gene, with which it is co-transcribed, and increases...
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Article
Open AccessTumor-directed gene therapy in mice using a composite nonviral gene delivery system consisting of the piggyBac transposon and polyethylenimine
Compared with viral vectors, nonviral vectors are less immunogenic, more stable, safer and easier to replication for application in cancer gene therapy. However, nonviral gene delivery system has not been exte...
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Article
Dysfunction of Murine Dendritic Cells Induced by Incubation with Tumor Cells
In vivo studies showed that dendritic cell (DC) dysfunction occurred in tumor microenvironment. As tumors were composed of many kinds of cells, the direct effects of tumor cells on immature DCs (imDCs) are needed...
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Article
Cloning, expression and characterization of human tissue-specific DNA polymerase λ2
DNA polymerase (POL) λ plays an important role during DNA repair and DNA nonhomologous recombination processes. A novel POL λ variant was cloned from a human liver cDNA library and named POL λ2 (GenBank Accession...
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Article
Open AccessKIAA0101 (OEACT-1), an expressionally down-regulated and growth-inhibitory gene in human hepatocellular carcinoma
Our previous cDNA array results indicated KIAA0101 as one of the differentially expressed genes in human hepatocellular carcinoma (HCC) as compared with non-cancerous liver. However, it is necessary to study i...
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Article
Open AccessMethylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis
Hepatocellular carcinoma (HCC) presents one of the major health threats in China today. A better understanding of the molecular genetics underlying malignant transformation of hepatocytes is critical to succes...
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Article
Enhanced antitumor effect of EGF R–targeted p21WAF-1 and GM-CSF gene transfer in the established murine hepatoma by peritumoral injection
One of the major obstacles in current cancer gene therapy is the lack of a gene delivery system with high efficiency and targetability. In this paper, a nonviral gene delivery system GE7, which was designed to...
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Article
Computational analysis and prediction for exons of PAC579 genomic sequence
To isolate the novel genes related to human hepatocellular carcinoma (HCC), we sequenced P1-derived artificial chromosome PAC579 (D17S926 locus) mapped in the minimum LOH (loss of heterozygosity) deletion regi...
