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Open AccessTWEAK/Fn14 signalling driven super-enhancer reprogramming promotes pro-metastatic metabolic rewiring in triple-negative breast cancer
Triple Negative Breast Cancer (TNBC) is the most aggressive breast cancer subtype suffering from limited targeted treatment options. Following recent reports correlating Fibroblast growth factor-inducible 14 (...
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Article
Open AccessDynamics of collagen oxidation and cross linking in regenerating and irreversibly infarcted myocardium
In mammalian hearts myocardial infarction produces a permanent collagen-rich scar. Conversely, in zebrafish a collagen-rich scar forms but is completely resorbed as the myocardium regenerates. The formation of...
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Article
Open AccessProgressive failure analysis of perforated composite laminates considering nonlinear shear effect
Composites are widely used in high performance structures such as aerospace structures due to their excellent properties. The analysis of failure evolution of composite perforated structures by finite element ...
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Article
Open AccessSmall RNA sequencing provides insights into molecular mechanism of flower development in Rhododendron pulchrum Sweet
Rhododendron pulchrum sweet, a member of the Ericaceae family possessing valuable horticultural properties, is widely distributed in the temperate regions. Though serving as bioindicator of metal pollution, the m...
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Article
Open AccessA high-quality chromosome-level wild rice genome of Oryza coarctata
Oryza coarctata (2n = 4X = 48, KKLL) is an allotetraploid, undomesticated relative of rice and the only species in the genus Oryza with tolerance to high salinity and submergence. Therefore, it contains important...
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Article
Open AccessPhosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells
In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T cells through an ‘inside out’ signalling process whereby structurally diverse phosphoantigen (pAg) molecules are sensed by the intr...
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Article
Open AccessIdentification of a two metastasis-related prognostic signature in the process of predicting the survival of laryngeal squamous cell carcinoma
Metastasis is a major cause of treatment failure and poor outcomes in cancer patients. The data used in the current study was downloaded from TCGA and GEO databases. Differentially expressed metastasis-related...
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Article
Open AccessThe healing capacity and osteogenesis pattern of demineralized dentin matrix (DDM)-fibrin glue (FG) compound
Demineralized dentin matrix (DDM) is an osteoconductive and osteoinductive material that has been successfully used in sinus floor augmentation and alveolar ridge augmentation in clinical applications. It rele...
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Article
Open AccessAggregation-regulated room-temperature phosphorescence materials with multi-mode emission, adjustable excitation-dependence and visible-light excitation
Constructing room-temperature phosphorescent materials with multiple emission and special excitation modes is fascinating and challenging for practical applications. Herein, we demonstrate a facile and general...
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Article
Open AccessA phylotranscriptomic dataset of angiosperm species under cold stress
Angiosperms are one of the most diverse and abundant plant groups that are widely distributed on Earth, from tropical to temperate and polar zones. The wide distribution of angiosperms may be attributed to the...
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Article
Open AccessCharacterization of genome-wide STR variation in 6487 human genomes
Short tandem repeats (STRs) are abundant and highly mutagenic in the human genome. Many STR loci have been associated with a range of human genetic disorders. However, most population-scale studies on STR vari...
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Publisher Correction: Structures and mechanisms of the Arabidopsis auxin transporter PIN3
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Open AccessNovel method to decrease the exposure time of the extraction string of the ureteral stent and its efficiency and safety verification in the clinic
Ureteral stent removal by an extraction string is advantageous. However, the increased risk of complications attributed to the continuous exposure of the string outside the urethra must be managed. This paper ...
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Open AccessPseudoknot length modulates the folding, conformational dynamics, and robustness of Xrn1 resistance of flaviviral xrRNAs
To understand how RNA dynamics is regulated and connected to its function, we investigate the folding, conformational dynamics and robustness of Xrn1 resistance of a set of flaviviral xrRNAs using SAXS, smFRET...
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Article
Open AccessWdr47, Camsaps, and Katanin cooperate to generate ciliary central microtubules
The axonemal central pair (CP) are non-centrosomal microtubules critical for planar ciliary beat. How they form, however, is poorly understood. Here, we show that mammalian CP formation requires Wdr47, Camsaps...
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Open AccessImpact of neovascular age-related macular degeneration: burden of patients receiving therapies in Japan
The chronic eye disorder, neovascular age-related macular degeneration (nAMD), is a common cause of permanent vision impairment and blindness among the elderly in developed countries, including Japan. This stu...
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Open AccessAuthor Correction: Determinants of genome-wide distribution and evolution of uORFs in eukaryotes
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22435-2
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Open AccessDeterminants of genome-wide distribution and evolution of uORFs in eukaryotes
Upstream open reading frames (uORFs) play widespread regulatory functions in modulating mRNA translation in eukaryotes, but the principles underlying the genomic distribution and evolution of uORFs remain poor...
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Open AccessImpact of deviation from guideline recommended treatment on breast cancer survival in Asia
Breast cancer survival has improved with significant progress in treatment and disease management. However, compliance with treatment varies. Treatment guidelines for older patients are unclear. We aim to iden...
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Open AccessSingle-handed supramolecular double helix of homochiral bis(N-amidothiourea) supported by double crossed C−I···S halogen bonds
The natural DNA double helix consists of two strands of nucleotides that are held together by multiple hydrogen bonds. Here we propose to build an artificial double helix from fragments of two strands connecte...