6 Result(s)

Article

Targeting RPA promotes autophagic flux and the antitumor response to radiation in nasopharyngeal carcinoma

Autophagy is involved in nasopharyngeal carcinoma (NPC) radioresistance. Replication protein A 1 (RPA1) and RPA3, substrates of the RPA complex, are potential therapeutic targets for reversing NPC radioresista...

Yanchun Feng, Yingming Jiang, Jun Liu, Jiaqi Liu… in Journal of Translational Medicine (2023)

Article

Intercellular adhesion molecule 2 as a novel prospective tumor suppressor induced by ERG promotes ubiquitination-mediated radixin degradation to inhibit gastric cancer tumorigenicity and metastasis

Gastric cancer (GC) is a fatal cancer with unclear pathogenesis. In this study, we explored the function and potential mechanisms of intercellular adhesion molecule 2 (ICAM2) in the development and advancement...

**aocheng Tang, **tuan Huang, Yingming Jiang, Jun Qiu… in Journal of Translational Medicine (2023)

Article

LAD1 promotes malignant progression by diminishing ubiquitin-dependent degradation of vimentin in gastric cancer

Ladinin-1 (LAD1), an anchoring filament protein, has been associated with several cancer types, including cancers of the colon, lungs, and breast. However, it is still unclear how and why LAD1 causes gastric c...

Yingming Jiang, Yanchun Feng, **tuan Huang… in Journal of Translational Medicine (2023)

Article

ADAMTS10 inhibits aggressiveness via JAK/STAT/c-MYC pathway and reprograms macrophage to create an anti-malignant microenvironment in gastric cancer

A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAMTS10) plays a role in extracellular matrix and correlates with Weill–Marchesani syndrome. However, its role in gastric cancer remains unkn...

Junyi Zhou, Tuoyang Li, Hao Chen, Yingming Jiang, Yandong Zhao… in Gastric Cancer (2022)

Article

Correction: Epigenetic silencing and tumor suppressor gene of HAND2 by targeting ERK signaling in colorectal cancer

Zixu Yuan, **hu Yu, Wenle Chen, Daici Chen, Jian Cai… in Cell Communication and Signaling (2022)

Article

Epigenetic silencing and tumor suppressor gene of HAND2 by targeting ERK signaling in colorectal cancer

The screening biomarkers for early detection of colorectal cancer (CRC) is lacking. The aim is to identify epigenetic silenced genes and clarify its roles and underlying mechanism in CRC. We conducted integrat...

Zixu Yuan, **hu Yu, Wenle Chen, Daici Chen, Jian Cai… in Cell Communication and Signaling (2022)