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Article
Role of Helicobacter pylori virulence factors and alteration of the Tumor Immune Microenvironment: challenges and opportunities for Cancer Immunotherapy
Various forms of malignancies have been linked to Helicobacter pylori. Despite advancements in chemotherapeutic and surgical approaches, the management of cancer, particularly at advanced stages, increasingly rel...
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Article
Automated synthesis of oxygen-producing catalysts from Martian meteorites by a robotic AI chemist
Living on Mars requires the ability to synthesize chemicals that are essential for survival, such as oxygen, from local Martian resources. However, this is a challenging task. Here we demonstrate a robotic art...
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Chapter and Conference Paper
How to Design Scientific, Happy and Effective Educational Games: Research on Educational Game Design from the Perspective of Learning Sciences
Game-based learning has become a research hotspot in the field of educational technology, but how to design scientific, happy and effective educational games is still an important challenge. In this paper, we ...
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Article
Effects of different feedback strategies on academic achievements, learning motivations, and self-efficacy for novice programmers
Providing appropriate feedback is important when learning to program. However, it is still unclear how different feedback strategies affect learning outcomes in programming. This study designed four different ...
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Article
Open AccessA novel small compound TOIDC suppresses lipogenesis via SREBP1-dependent signaling to curb MAFLD
Inhibition of hepatic lipogenesis is widely regarded as an effective treatment for metabolic-associated fatty liver disease (MAFLD), although numerous related drugs have failed to reach clinical application. T...
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Article
ADAMTS10 inhibits aggressiveness via JAK/STAT/c-MYC pathway and reprograms macrophage to create an anti-malignant microenvironment in gastric cancer
A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAMTS10) plays a role in extracellular matrix and correlates with Weill–Marchesani syndrome. However, its role in gastric cancer remains unkn...
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Article
Open AccessThe database of eye-movement measures on words in Chinese reading
Eye movements are one of the most fundamental behaviors during reading. A growing number of Chinese reading studies have used eye-tracking techniques in the last two decades. The accumulated data provide a ric...
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Chapter
The BivarIntCensored: An R Package for Nonparametric Inference of Bivariate Interval-Censored Data
Bivariate event time data are constantly encountered in biomedical research. In many real-life applications, both event times are possibly subject to interval censoring that gives rise to bivariate interval-ce...
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Article
Open AccessOn the Development of New Test Techniques to Measure the Tensile Response of Materials at High and Ultra-high Strain Rates
There is a lack of reliable methods to obtain valid measurements of the tensile response of high performance materials such as fibre composites, ceramics and textile products at high rates of strain.
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Article
Open AccessHuanglian Jiedu decoction remodels the periphery microenvironment to inhibit Alzheimer’s disease progression based on the “brain-gut” axis through multiple integrated omics
In recent years, excellent results have suggested an association between the “brain-gut” axis and Alzheimer’s disease (AD) progression, yet the role of the “brain-gut” axis in AD pathogenesis still remains obs...
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Chapter and Conference Paper
Exploring Interaction Qualities from Teenagers’ Studying Behavior for Learning Feature in Museum Exhibit
Increasing interactivity in exhibit is always an issue in museum exhibition, nowadays education becomes an important feature in museum, and how to impart knowledge in an interactive way, have audiences underst...
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Article
Open AccessCorrection to: A multifunctional platform with single-NIR-laser-triggered photothermal and NO release for synergistic therapy against multidrug-resistant Gram-negative bacteria and their biofilms
An amendment to this paper has been published and can be accessed via the original article.
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Article
Bi volatilization and conduction mechanism of rapidly liquid phase sintering La-doped BiFeO3 perovskite ceramics
LaxBi1−xFeO3 (LBFO) materials were synthesized by sol–gel method with x = 0.0, 0.1, 0.2, and 0.3. LBFO ceramics were obtained by rapid liquid phase sintering and conventional sintering, respectively. X-ray diffra...
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Article
Radiomic features of Pk-DCE MRI parameters based on the extensive Tofts model in application of breast cancer
To explore radiomic features of pharmacokinetic dynamic contrast-enhanced (Pk-DCE) MRI on the extensive Tofts model to diagnose breast cancer and predict molecular phenotype. Breast lesions enrolled must under...
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Article
Open AccessA multifunctional platform with single-NIR-laser-triggered photothermal and NO release for synergistic therapy against multidrug-resistant Gram-negative bacteria and their biofilms
Infectious diseases caused by multidrug-resistant (MDR) bacteria, especially MDR Gram-negative strains, have become a global public health challenge. Multifunctional nanomaterials for controlling MDR bacterial...
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Article
The anti-inflammatory effects of formononetin and ononin on lipopolysaccharide-induced zebrafish models based on lipidomics and targeted transcriptomics
Formononetin (MBHS) and its glycosylated derivative ononin (MBHG), as the major isoflavones, have exhibited the anti-inflammatory impacts on the lipopolysaccharide (LPS)-induced inflammation. Although various ...
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Article
Open AccessJoint contractures in severe burn patients with early rehabilitation intervention in one of the largest burn intensive care unit in China: a descriptive analysis
Joint contracture is the major clinical complication in burn patients, especially, the severe burn patients. This study aimed to investigate the number and severity of joint contractures in patients with burns...
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Article
Construction of glucose and H2O2 dual stimuli-responsive polymeric vesicles and their application in controlled drug delivery
Herein, glucose and H2O2 stimuli-responsive vesicles are constructed based on host–guest interaction between a diblock copolymer, poly(ethylene glycol)-b-poly[3-acrylamidophenylboronic acid-co-4-(4,4,5,5-tetrame...
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Article
The time course of incremental word processing during Chinese reading
In the current study, we report two eye movement experiments investigating how Chinese readers process incremental words during reading. These are words where some of the component characters constitute anothe...
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Article
Skip** of Chinese characters does not rely on word-based processing
Previous eye-movement studies have indicated that people tend to skip extremely high-frequency words in sentence reading, such as “the” in English and “的/de” in Chinese. Two alternative hypotheses have been pr...
