5 Result(s)
within
Ying-hua Ma
Life Sciences
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Article
Impaired reproduction in transgenic mice overexpressing γ-aminobutyric acid transporter I (GAT1)
It is well documented that γ-aminobutyric acid (GABA) system existed in reproductive organs. Recent researches showed that GABAA and GABAB receptors were present in testis and sperm, and might mediate the acrosom...
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Article
Enhancement of germ cell apoptosis induced by ethanol in transgenic mice overexpressing Fas Ligand
It was suggested that chronic ethanol exposure could result in testicular germ cell apoptosis, but the mechanism is still unclear. In the present study, we use a model of transgenic mice ubiquitously overexpre...
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Article
Overexpression of γ-aminobutyric acid transporter subtype I leads to susceptibility to kainic acid-induced seizure in transgenic mice
γ-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter, and the GABAergic synaptic transmission is normally terminated by the rapid uptake through GABA transporters. With transgenic mice ubiqui.....
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Article
Transgenic mice overexpressing γ-aminobutyric acid transporter subtype I develop obesity
Transgenic mice ubiquitously overexpressing murine r-aminobutyric acid transporter subtype I were created. Unexpectedly, these mice markedly exhibited heritable obesity, which features significantly increased ...
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Article
γ-Aminobutyric acid transporter (GAT1) overexpression in mouse affects the testicular morphology
γ-Aminobutyric acid and GABAergic receptors were previously reported to be distributed in reproductive systems besides CNS and predicted to participate in the modulation of testicular function. γ-Aminobutyric aci...
