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Article
Open AccessA black phosphorus nanosheet-based RNA delivery system for prostate cancer therapy by increasing the expression level of tumor suppressor gene PTEN via CeRNA mechanism
Prostate cancer (PCa) has a high incidence in men worldwide, and almost all PCa patients progress to the androgen-independent stage which lacks effective treatment measures. PTENP1, a long non-coding RNA, has ...
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Article
Long-term changes of surface ozone and ozone sensitivity over the North China Plain based on 2015–2021 satellite retrievals
Despite the implementation of stringent pollution control measures, surface ozone (O3) pollution remains a significant issue in the North China Plain (NCP) in recent years. Here we examined long-term changes in s...
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Article
Open AccessAssociation of leukocyte telomere length with risk of all-cause and cardiovascular mortality in middle-aged and older individuals without cardiovascular disease: a prospective cohort study of NHANES 1999–2002
Leukocyte telomere length (LTL) shorting was significantly associated with mortality. This study aimed to investigate the potential association between LTL and all-cause mortality as well as cardiovascular dis...
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Article
Open AccessPRDX1 exerts a photoprotection effect by inhibiting oxidative stress and regulating MAPK signaling on retinal pigment epithelium
The purpose of this study was to investigate the photoprotection effect of peroxiredoxin 1 (PRDX1) protein in ultraviolet B (UVB) irradiation-induced damage of retinal pigment epithelium (RPE) and its possible...
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Article
Piracetam reduces oxidative stress and mitochondrial function impairment in an in vitro model of vascular dementia
Vascular dementia (VaD) is the most common cause of dementia in older adults. Due to the lack of effective treatment options, there is an urgent need to find an effective pharmaceutical compound to combat VaD....
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Article
Low frequency magnetic field assisted production of acidic protease by Aspergillus niger
Acid protease is widely used in industries such as food processing and feed additives. In the study, low frequency magnetic field (LF-MF) as an aid enhances acid protease production by Aspergillus niger (A. niger
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Article
Effect of Stretch Bending on the Microstructure and Mechanical Properties of AZ31 Magnesium Alloy
The stretch-bending straightening is an effective way to improve the accuracy of sheet assembly. The effect of stretch-bending on the microstructure, deformation behavior and mechanical properties of the extru...
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Article
Phyllospheric Microorganisms and Bean Characteristics Influence Quality of Ten Genotypes of Coffea Arabica
Purpose: Phyllospheric microorganisms are among the most vital factors that influence the flavor and taste of coffee (Coffea arabica). Little is known about the relationship between bean properties in C. arabica ...
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Article
Open AccessHigh hydrostatic pressure stimulates microbial nitrate reduction in hadal trench sediments under oxic conditions
Hadal trenches are extreme environments situated over 6000 m below sea surface, where enormous hydrostatic pressure affects the biochemical cycling of elements. Recent studies have indicated that hadal trenche...
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Article
Open AccessCD19/CD20 dual-targeted chimeric antigen receptor-engineered natural killer cells exhibit improved cytotoxicity against acute lymphoblastic leukemia
Chimeric antigen receptor natural killer (CAR-NK) cells represent a promising advancement in CAR cell therapy, addressing limitations observed in CAR-T cell therapy. However, our prior study revealed challenge...
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Article
Open AccessPharmacokinetics and pharmacodynamics of antibacterial peptide NZX in Staphylococcus aureus mastitis mouse model
Staphylococcus aureus is associated with dairy mastitis, which causes serious economic losses to dairy farming industry. Antibacterial peptide NZX showed good antibacterial activity against S. aureus. This study ...
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Article
Effect of Crack Defect of a Spur Gear System with Time-Varying Friction and Dynamic Backlash on Vibration Characteristics and Its Experimental Research
The vibration characteristics of gear transmission systems with a fault can be influenced by nonlinear factors. To obtain accurate fault vibration signals and analyze vibration characteristics, a nonlinear dyn...
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Article
Open AccessThe association between the AIP and undiagnosed diabetes in ACS patients with different body mass indexes and LDL-C levels: findings from the CCC-ACS project
The atherogenic index of plasma (AIP) has been demonstrated to be significantly associated with the incidence of prediabetes and diabetes. This study aimed to investigate the association between the AIP and u...
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Article
Open AccessTREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53
Efferocytosis and metabolic reprogramming of macrophages play crucial roles in myocardial infarction (MI) repair. TREM2 has been proven to participate in phagocytosis and metabolism, but how it modulates myoca...
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Article
Recent advances in targeted protein degraders as potential therapeutic agents
Targeted protein degradation (TPD) technology has gradually become widespread in the past 20 years, which greatly boosts the development of disease treatment. Contrary to small inhibitors that act on protein k...
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Article
Energy and Cache Aware Routing for Socially Aware Networking in the Big Data Environment
In the big data environment, Socially Aware Networking (SAN) can obtain a large amount of status data and social contacts of network nodes. If the information is fully analyzed and utilized, it will effectivel...
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Article
Open AccessIdentification of HSP90B1 in pan-cancer hallmarks to aid development of a potential therapeutic target
Heat shock proteins play crucial roles in various biochemical processes, encompassing protein folding and translocation. HSP90B1, a conserved member of the heat shock protein family, growing evidences have dem...
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Article
Open AccessChimeric antigen receptor-based natural killer cell immunotherapy in cancer: from bench to bedside
Immunotherapy has rapidly evolved in the past decades in the battle against cancer. Chimeric antigen receptor (CAR)-engineered T cells have demonstrated significant success in certain hematologic malignancies,...
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Article
Open AccessExpression and characterization of the new antimicrobial peptide AP138L-arg26 anti Staphylococcus aureus
The low activity and yield of antimicrobial peptides (AMPs) are pressing problems. The improvement of activity and yield through modification and heterologous expression, a potential way to solve the problem, ...
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Article
Open AccessGenome-wide identification and expression pattern analysis of the kiwifruit GRAS transcription factor family in response to salt stress
GRAS is a family of plant-specific transcription factors (TFs) that play a vital role in plant growth and development and response to adversity stress. However, systematic studies of the GRAS TF family in kiwi...
