-
Article
Luminescence modulation of ultrasmall gold clusters by aromatic ligands
Luminescence is one of the most important properties for metal nanoclusters; however, clearly revealing its origin remains challenging. The different luminescence properties of the two prototypical 8e nanoclus...
-
Article
Open AccessCarbene-stabilized enantiopure heterometallic clusters featuring EQE of 20.8% in circularly-polarized OLED
Bright and efficient chiral coinage metal clusters show promise for use in emerging circularly polarized light-emitting materials and diodes. To date, highly efficient circularly polarized organic light-emitti...
-
Article
Open AccessActivity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility
Voltage-gated K+ channels function in macromolecular complexes with accessory subunits to regulate brain function. Here, we describe a peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)-dependent mecha...
-
Article
Preso1 dynamically regulates group I metabotropic glutamate receptors
The authors show that Preso1 acts as a scaffolding protein that binds mGluR, Homer and proline-directed kinases. Deletion of Preso1 prevents phosphorylation of mGluR at the Homer binding site and leads to an i...
-
Article
Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome
This study shows that the interaction between metabotropic glutamate receptor 5 (mGluR5) and a specific form of the scaffolding protein Homer contributes to the behavioral and physiological defects in the mous...
-
Article
Impaired reproduction in transgenic mice overexpressing γ-aminobutyric acid transporter I (GAT1)
It is well documented that γ-aminobutyric acid (GABA) system existed in reproductive organs. Recent researches showed that GABAA and GABAB receptors were present in testis and sperm, and might mediate the acrosom...
-
Article
Enhancement of germ cell apoptosis induced by ethanol in transgenic mice overexpressing Fas Ligand
It was suggested that chronic ethanol exposure could result in testicular germ cell apoptosis, but the mechanism is still unclear. In the present study, we use a model of transgenic mice ubiquitously overexpre...
-
Article
Overexpression of γ-aminobutyric acid transporter subtype I leads to susceptibility to kainic acid-induced seizure in transgenic mice
γ-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter, and the GABAergic synaptic transmission is normally terminated by the rapid uptake through GABA transporters. With transgenic mice ubiqui.....
-
Article
Transgenic mice overexpressing γ-aminobutyric acid transporter subtype I develop obesity
Transgenic mice ubiquitously overexpressing murine r-aminobutyric acid transporter subtype I were created. Unexpectedly, these mice markedly exhibited heritable obesity, which features significantly increased ...
-
Article
γ-Aminobutyric acid transporter (GAT1) overexpression in mouse affects the testicular morphology
γ-Aminobutyric acid and GABAergic receptors were previously reported to be distributed in reproductive systems besides CNS and predicted to participate in the modulation of testicular function. γ-Aminobutyric aci...
