107 Result(s)

Article

Neutrophil-derived migrasomes are an essential part of the coagulation system

Migrasomes are organelles that are generated by migrating cells. Here we report the key role of neutrophil-derived migrasomes in haemostasis. We found that a large number of neutrophil-derived migrasomes exist...

Dong Jiang, Lin Jiao, Qing Li, Renxiang **e, Haohao Jia, ShiHui Wang… in Nature Cell Biology (2024)

Article

The role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis

Colorectal cancer (CRC) remains a significant global health issue with high incidence and mortality. Yin Yang 1 (YY1) is a powerful transcription factor that acts dual roles in gene activation and repression. ...

Zhi-Ying Shao, Wen-Dong Yang, Hui Qiu, Zhi-Hong He, Meng-Ru Lu… in Cell Death & Disease (2024)

Article

Efficacy and safety of novel multifunctional M10 CAR-T cells in HIV-1-infected patients: a phase I, multicenter, single-arm, open-label study

Chimeric antigen receptor T (CAR-T) cells have been proposed for HIV-1 treatment but have not yet demonstrated desirable therapeutic efficacy. Here, we report newly developed anti-HIV-1 CAR-T cells armed with ...

Yunyu Mao, Qibin Liao, Youwei Zhu, Mingyuan Bi, Jun Zou, Nairong Zheng… in Cell Discovery (2024)

Article

Editorial Expression of Concern: HDAC2 phosphorylation-dependent Klf5 deacetylation and RARα acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs

Bin Zheng, Mei Han, Ya-nan Shu, Ying-jie Li, Sui-bing Miao, **n-hua Zhang… in Cell Research (2024)

Article

The LRR receptor-like kinase ALR1 is a plant aluminum ion sensor

Plant survival requires an ability to adapt to differing concentrations of nutrient and toxic soil ions, yet ion sensors and associated signaling pathways are mostly unknown. Aluminum (Al) ions are highly phyt...

Zhong Jie Ding, Chen Xu, **g Ying Yan, Yu Xuan Wang, Meng Qi Cui… in Cell Research (2024)

Article

Mycobacterium tuberculosis inhibits METTL14-mediated m⁶A methylation of Nox2 mRNA and suppresses anti-TB immunity

Internal N⁶-methyladenosine (m⁶A) modifications are among the most abundant modifications of messenger RNA, playing a critical role in diverse biological and pathological processes. However, the functional role a...

Mingtong Ma, Yongjia Duan, Cheng Peng, You Wu, **nning Zhang, Boran Chang… in Cell Discovery (2024)

Article

Advanced oxidation protein products attenuate the autophagy-lysosome pathway in ovarian granulosa cells by modulating the ROS-dependent mTOR-TFEB pathway

Oxidative stress dysfunction has recently been found to be involved in the pathogenesis of premature ovarian insufficiency (POI). Previously, we found that advanced oxidation protein products (AOPPs) in plasma...

**ng-Yu Zhou, Yun-Hui Lai, Jun Zhang, Ying Li, **ao-Min Wu… in Cell Death & Disease (2024)

Article

Development of synthetic modulator enabling long-term propagation and neurogenesis of human embryonic stem cell-derived neural progenitor cells

Neural progenitor cells (NPCs) are essential for in vitro drug screening and cell-based therapies for brain-related disorders, necessitating well-defined and reproducible culture systems. Current strategies em...

Ceheng Liao, Ying Guan, Jihui Zheng, Xue Wang, Meixia Wang… in Biological Research (2023)

Article

ATP-citrate lyase controls endothelial gluco-lipogenic metabolism and vascular inflammation in sepsis-associated organ injury

Sepsis involves endothelial cell (EC) dysfunction, which contributes to multiple organ failure. To improve therapeutic prospects, elucidating molecular mechanisms of vascular dysfunction is of the essence. ATP...

Ranran Li, Mei Meng, Ying Chen, Tingting Pan, Yinjiaozhi Li… in Cell Death & Disease (2023)

Article

Electroacupuncture inhibits dendritic spine remodeling through the srGAP3-Rac1 signaling pathway in rats with SNL

Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal horn neurons. Inhibition of abnormal dendritic spine remodeling can relieve neuropathic...

Qiaoyun Wu, Chenchen Cai, **nwang Ying, Yujun Zheng, Jiaying Yu… in Biological Research (2023)

Article

Age-related elevation of O-GlcNAc causes meiotic arrest in male mice

In recent years, the postponement of childbearing has become a critical social issue. Male fertility is negatively associated with age because of testis aging. Spermatogenesis is impaired with age, but the mol...

Zhang Qian, Chuwei Li, Shanmeizi Zhao, Hong Zhang, Rujun Ma, **e Ge… in Cell Death Discovery (2023)

Article

Liquid biopsy on the horizon in immunotherapy of non-small cell lung cancer: current status, challenges, and perspectives

Non-small cell lung cancer (NSCLC) is one of the most threatening malignancies to human health and life. In most cases, patients with NSCLC are already at an advanced stage when they are diagnosed. In recent y...

Ying Yang, Hongyang Liu, Youming Chen, Nan **ao, Zhaoyang Zheng… in Cell Death & Disease (2023)

Article

CD36⁺ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor

Hepatocellular carcinoma (HCC) is an immunotherapy-resistant malignancy characterized by high cellular heterogeneity. The diversity of cell types and the interplay between tumor and non-tumor cells remain to b...

Gui-Qi Zhu, Zheng Tang, Run Huang, Wei-Feng Qu, Yuan Fang, Rui Yang… in Cell Discovery (2023)

Article

Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5

SARS-CoV-2 Omicron subvariants have demonstrated extensive evasion from monoclonal antibodies (mAbs) developed for clinical use, which raises an urgent need to develop new broad-spectrum mAbs. Here, we report ...

Yanqun Wang, An Yan, Deyong Song, Chuangchuang Dong, Muding Rao… in Cell Discovery (2023)

Article

Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Antibody resistance dampens neutralizing antibody therapy and threatens current global Coronavirus (COVID-19) vaccine ...

Bingqing **a, **aoyan Pan, Rong-Hua Luo, Xurui Shen, Shuangqu Li, Yi Wang… in Cell Discovery (2023)

Article

A distal super-enhancer activates oncogenic ETS2 via recruiting MECOM in inflammatory bowel disease and colorectal cancer

Abnormal activities of distal cis-regulatory elements (CREs) contribute to the initiation and progression of cancer. Gain of super-enhancer (SE), a highly active distal CRE, is essential for the activation of ...

Yongheng Chen, Ying Ying, Maolin Wang, Canjie Ma, Min Jia… in Cell Death & Disease (2023)