-
Article
Editorial Expression of Concern: HDAC2 phosphorylation-dependent Klf5 deacetylation and RARα acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs
-
Article
Open AccessPregnancy outcome and follow-up of offspring of donor oocytes recipient from PCOS patients
The use of donated oocytes (DO) for in vitro fertilization(IVF) treatment in patients with infertility is generally recognized, and females with polycystic ovarian syndrome (PCOS) can participate in oocyte don...
-
Article
Open AccessGlutamine as a Potential Noninvasive Biomarker for Human Embryo Selection
To determine whether glutamine consumption is associated with embryo quality and aneuploidy, a retrospective study was conducted in an in vitro fertilization center. Spent embryo culture media from patients un...
-
Article
Insulin-independent GLUT4 translocation in proliferative vascular smooth muscle cells involves SM22α
The insulin-sensitive glucose transporter 4 (GLUT4) is a predominant facilitative glucose transporter in vascular smooth muscle cells (VSMCs) and is significantly upregulated in rabbit neointima. This study in...
-
Article
Smooth muscle 22α facilitates angiotensin II-induced signaling and vascular contraction
Smooth muscle 22α (SM22α) is involved in stress fiber formation and enhances contractility in vascular smooth muscle cells (VSMCs). In many cases, SM22α acts as an adapter protein to assemble signaling complex...
-
Article
KLF5 and hhLIM cooperatively promote proliferation of vascular smooth muscle cells
Krüppel-like factor 5 (KLF5) plays an important role in cellular proliferation and differentiation. In this study, we show that adenovirus-mediated overexpression of KLF5 increased neointimal formation, while ...
-
Article
HDAC2 phosphorylation-dependent Klf5 deacetylation and RARα acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs
Abnormal proliferation of vascular smooth muscle cells (VSMCs) occurs in hypertension, atherosclerosis and restenosis after angioplasty, leading to pathophysiological vascular remodeling. As an important growt...
-
Article
Erratum: Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRβ-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia
Correction to: Cell Research (2011) 20:1252–1262. doi:10.1038/cr.2010.111; published online 27 July 2010 The authors would like to clarify a deficiency in our paper recently published in Cell Research (CR) (20...
-
Article
Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRβ-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia
The increased proliferation and migration of vascular smooth muscle cells (VSMCs) are key events in the development of atherosclerotic lesions. Baicalin, an herb-derived flavonoid compound, has been previously...
-
Article
Open AccessPolymorphisms of the ICAM-1 exon 6 (E469K) are associated with differentiation of colorectal cancer
Genetic factors are thought to play a role in development for colorectal carcinogenesis. ICAM-1 is a polymorphic gene, thus, the present study investigated the relationship between the polymorphisms of ICAM-1 and...
