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Article
Development and validation of HPV-associated and HPV-independent penile squamous cell carcinoma prognostic nomogram
The aim of this study was to introduce HPV-associated and HPV-independent histologic classifications to analyze prognostic factors and develop a prognostic nomogram for patients with penile squamous cell carci...
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Article
Composition and Construction of High- and Low-Energy Ooid Shoals and Their Relationships with Environmental Changes: A Case Study from the Cambrian Zhangxia Formation in the Ordos Basin, North China
On the basis of systematic study of sedimentary facies, microfacies and geochemistry of measured strata sections and wells, the ooid shoals of the Cambrian Miaolingian Zhangxia Formation in the southern Ordos ...
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Article
TRIM59 is suppressed by androgen receptor and acts to promote lineage plasticity and treatment-induced neuroendocrine differentiation in prostate cancer
The incidence of treatment-induced neuroendocrine prostate cancer (t-NEPC) has been greatly increasing after the usage of secondgeneration androgen receptor (AR) pathway inhibitors (ARPIs). Neuroendocrine diff...
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Article
Novel Pd/Al2O3–CeO2 Nanosheets for One-Pot Synthesis of Methyl Isobutyl Ketone from Acetone
A Pd/Al2O3–CeO2 nanosheets catalyst was fabricated successfully via coprecipitation strategy for the one-pot conversion of acetone to methyl isobutyl ketone (MIBK). Compared with Pd/Al2O3 or Pd/CeO2, Pd/Al2O3–CeO
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Article
Open AccessAllopatric molting of Devonian trilobites
Trilobite exuviae record the development of individual trilobites and their molting process and can also contain information on their behavior. The silt- to fine-grained tuffites of the middle part of the Midd...
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Article
Gremlin1 is a therapeutically targetable FGFR1 ligand that regulates lineage plasticity and castration resistance in prostate cancer
Among the greatest hurdles in clinical management of prostate cancer (PCa) are the progression to lethal castration-resistant prostate cancer (CRPC) and the lack of suitable targeted therapies for advanced dis...
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Article
Three-dimensional visualization technique compared with magnetic resonance cholangiopancreatography for evaluation of anatomic variants of pediatric congenital choledochal cysts
The aim of this study was to compare the application of a three-dimensional (3D) visualization technique and magnetic resonance cholangiopancreatography (MRCP) for diagnosis of pediatric congenital choledochal...
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Article
Ostracods from the Devonian-Carboniferous transition in Dushan of Guizhou, South China
Thirty-seven ostracod species belonging to 25 genera from the Devonian-Carboniferous (D/C) transition in Dushan of Guizhou, South China are identified and figured. The stratigraphical distribution of ostracods...
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Article
Tentaculitids and their evolutionary significance in the Early Devonian Dashatian section, South China
Tentaculitoids have long been recognised as an enigmatic group of marine invertebrates that are widely distributed and highly diversified in the Silurian and Devonian strata. A tentaculitid assemblage is descr...
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Article
Open AccessAbiraterone acetate for chemotherapy-naive metastatic castration-resistant prostate cancer: a single-centre prospective study of efficacy, safety, and prognostic factors
To evaluate the efficacy and safety of abiraterone acetate (AA) plus prednisone compared with prednisone alone in Asian patients with chemotherapy-naive metastatic castration-resistant prostate cancer (mCRPC),...
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Article
Gastroschisis in monochorionic male twins
We report a case of gastroschisis in male twins. Both twins were preterm and low birth weight, with intestinal malrotation; they were diagnosed by antenatal ultrasound at 20 weeks of gestation. Immediately aft...
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Article
Open AccessLaser beam melting 3D printing of Ti6Al4V based porous structured dental implants: fabrication, biocompatibility analysis and photoelastic study
Fabricating Ti alloy based dental implants with defined porous scaffold structure is a promising strategy for improving the osteoinduction of implants. In this study, we use Laser Beam Melting (LBM) 3D printin...
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Article
Expression of Sp7 in Satb2-induced osteogenic differentiation of mouse bone marrow stromal cells is regulated by microRNA-27a
Satb2 is a special AT-rich binding transcription factor essential for osteoblast differentiation and bone formation. Specific microRNAs (miRNAs) have been identified to regulate the complex process of osteogen...
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Article
Ordovician radiolarians from the Yinisala ophiolitic mélange and their significance in western Junggar, **njiang, NW China
The Yinisala ophiolitic mélange is located in the southern part of the **emisitai Mountains in western Junggar (NW China), and is composed of mafic-ultra mafic rocks, siliceous blocks, marble (marbleized limes...
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Article
Phosphatic microspherules and their geobiological implications from the Frasnian-Famennian transition at the Yangdi section, Guilin, South China
Abundant perfectly-preserved phosphatic microspherules have been discovered across the Frasnian-Famennian (F-F) transition from the Yangdi section in Guilin, Guangxi, South China. They are mostly spherical or ...
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Article
MicroRNA expression signature for Satb2-induced osteogenic differentiation in bone marrow stromal cells
Satb2 acts as a potent transcription factor to promote osteoblast differentiation and bone regeneration. Recently, microRNAs (miRNA) have been identified as critical regulators of osteogenic differentiation. T...
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Article
Blooming of bacteria and algae is a biokiller for mass-extinction of Devonian coral-stromatoporoid reef ecosystems
Studies of rock slices showed that there were many kinds of symbioses between bacteria and algae and corals-stromatoporoids in the coral-stromatoporoid reefs from the Devonian Ganxi section of Sichuan and the ...
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Article
Open AccessGeomicrobial functional groups: A window on the interaction between life and environments
Microbes are well-known for their great diversity and abundance in modern natural environments. They also are believed to provide critical links among higher organisms and their associated environments. Howeve...
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Article
Hydrothermal activities and seawater acidification in the Late Devonian F-F transition: Evidence from geochemistry of rare earth elements
Rare-earth elements (REE) in limestones were measured by ICP-MS from the Yangdi section across the Frasnian-Famennian (F-F) transition in Guilin, Guangxi of South China. The average ΣREE contents of measured s...
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Article
Carboniferous coprolites from Qinhuangdao, North China
Here we reported the coprolites that are preserved in the dark grey silty shale of the Carboniferous Benxi Formation from Shimenzhai, Qinhuangdao, North China. The coprolites occur in a sinusoidal and ribbon-l...
