-
Article
Open AccessNPRL2 is required for proliferation of oncogenic Ras-transformed bronchial epithelial cells
Nitrogen permease regulator-like 2 (NPRL2/TUSC4) is known to exert both tumor-suppressing and oncogenic effects in different types of cancers, suggesting that its actions are context dependent. Here, we deline...
-
Article
Open AccessPrognostic value of arterial carbon dioxide tension during cardiopulmonary resuscitation in out-of-hospital cardiac arrest patients receiving extracorporeal resuscitation
Current guidelines on extracorporeal cardiopulmonary resuscitation (ECPR) recommend careful patient selection, but precise criteria are lacking. Arterial carbon dioxide tension (PaCO2) has prognostic value in out...
-
Chapter and Conference Paper
Overlap** Fingerprint Segmentation and Separation Based on Deep Learning
This study focuses on the application of semantic segmentation to address the challenge of overlap** fingerprint images with noisy backgrounds. Our approach involves excluding non-fingerprint regions and emp...
-
Chapter and Conference Paper
Fingerprint Image Enhancement Method Based on U-Net Model
Fingerprint image enhancement is a vital image processing technology that finds applications in fingerprint identification, matching, and biometric authentication. Its objective is to improve the performance a...
-
Article
Open AccessEffects of progressive body-weight versus barbell back squat training on strength, hypertrophy and body fat among sedentary young women
The objective of this study was to compare the effects of progressive bodyweight training and barbell back squat on muscle strength, muscluar hypertrophy, and body fat percentage in sedentary young women. Thir...
-
Article
Open AccessAuthor Correction: Rhythm control without catheter ablation may have benefits beyond stroke prevention in rivaroxaban-treated non-permanent atrial fibrillation
-
Article
Open AccessThe effects of high versus low frequency of combined physical and cognitive training on cognitive function in older adults with cognitive decline: a quasi-experimental study
The effects of combined training can be affected by training characteristics such as frequency, session length, and duration. No empirical studies to date have directly compared how combined physical and cogni...
-
Article
Open AccessDifferential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide associat...
-
Article
Urine DNA biomarkers for hepatocellular carcinoma screening
Hepatocellular carcinoma (HCC) occurs in a well-defined high-risk patient population, but better screening tests are needed to improve sensitivity and efficacy. Therefore, we investigated the use of urine circ...
-
Article
Open AccessRhythm control without catheter ablation may have benefits beyond stroke prevention in rivaroxaban-treated non-permanent atrial fibrillation
The current treatment paradigm for atrial fibrillation (AF) prioritizes rate control over rhythm control; however, rhythm control has shown benefits over other AF strategies. This study compares the outcomes o...
-
Article
Safety and Effectiveness of Rivaroxaban in Combination with Various Antiarrhythmic Drugs in Patients with Non-Permanent Atrial Fibrillation
Rivaroxaban reduces the risk of thromboembolism in atrial fibrillation (AF) patients, who often also receive antiarrhythmic drugs (AADs) to maintain sinus rhythm. Current guidelines contraindicate concomitant ...
-
Article
Open AccessUltrasonic microbubble VEGF gene delivery improves angiogenesis of senescent endothelial progenitor cells
The therapeutic effects of ultrasonic microbubble transfection (UMT)-based vascular endothelial growth factor 165 (VEGF165) gene delivery on young and senescent endothelial progenitor cells (EPCs) were investi...
-
Article
A deep-learning system for the assessment of cardiovascular disease risk via the measurement of retinal-vessel calibre
Retinal blood vessels provide information on the risk of cardiovascular disease (CVD). Here, we report the development and validation of deep-learning models for the automated measurement of retinal-vessel cal...
-
Article
Open AccessCommon variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract
Nuclear cataract is the most common type of age-related cataract and a leading cause of blindness worldwide. Age-related nuclear cataract is heritable (h2 = 0.48), but little is known about specific genetic facto...
-
Article
Open AccessS-Phase Kinase-associated Protein-2 Rejuvenates Senescent Endothelial Progenitor Cells and Induces Angiogenesis in Vivo
Cell cycle slowdown or arrest is a prominent feature of cellular senescence. S-phase kinase-associated protein-2 (Skp2), an F-box subunit of SCFSkp2 ubiquitin ligase, is a key regulator of G1/S transition. We inv...
-
Chapter and Conference Paper
Re-Trace: Relive and Share Your Story
Memories fade with time, so in the past we use photographs to keep memories alive. However, with the development of technology, taking photos is so easy that users no longer cherish them. In this study, we bui...
-
Chapter and Conference Paper
Technology Progress, Trade Openness, and Income Inequality: A Cross-Country Empirical Study
Since the 1990s, many countries encountering trade liberalization and rapid technological progress have experienced rising within-country income inequality. This paper investigates relationships between trade ...
-
Article
Mitochondrial fission protein 1 up-regulation ameliorates senescence-related endothelial dysfunction of human endothelial progenitor cells
We investigated the contribution of mitochondrial dysfunction to the senescence of human endothelial progenitor cells (EPCs) expanded in vitro and the underlying molecular mechanism.
-
Article
Open AccessGenome-wide association meta-analyses and fine-map** elucidate pathways influencing albuminuria
Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood...
-
Article
Open AccessKC21 Peptide Inhibits Angiogenesis and Attenuates Hypoxia-Induced Retinopathy
Desmogleins (Dsg2) are the major components of desmosomes. Dsg2 has five extracellular tandem cadherin domains (EC1-EC5) for cell-cell interaction. We had previously confirmed the Dsg2 antibody and its epitope...
