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  1. Article

    Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

    The Pyrin inflammasome detects the presence of a pathogen not through recognition of a microbial molecule but by the activity of a bacterial toxin that modifies host Rho activity.

    Hao Xu, Jieling Yang, Wenqing Gao, Lin Li, Peng Li, Li Zhang, Yi-Nan Gong… in Nature (2014)

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    Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation

    A conserved protein from enteropathogenic Escherichia coli, NleE, inhibits innate immune defence against infection by disrupting the NF-κB signalling pathway through methylation of ubiquitin-chain sensing protein...

    Li Zhang, **aojun Ding, Jixin Cui, Hao Xu, **g Chen, Yi-Nan Gong, Liyan Hu… in Nature (2012)

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    The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

    The inflammasomes are multiprotein complexes involved in innate immunity, and induce an immune response to pathogenic microbes by activating the caspase 1 protease. Two groups now report that the intracellular...

    Yue Zhao, Jieling Yang, Jian** Shi, Yi-Nan Gong, Qiuhe Lu, Hao Xu, Li** Liu… in Nature (2011)