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Article
Tumors evade immune cytotoxicity by altering the surface topology of NK cells
The highly variable response rates to immunotherapies underscore our limited knowledge about how tumors can manipulate immune cells. Here the membrane topology of natural killer (NK) cells from patients with l...
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Article
Open AccessMacrophage-Derived MMP-9 and MMP-2 are Closely Related to the Rupture of the Fibrous Capsule of Hepatocellular Carcinoma Leading to Tumor Invasion
Hepatocellular carcinoma (HCC) is an aggressive tumor with a poor clinical prognosis. Rupture of the fibrous capsule (FC) is a very important clinical phenomenon in the invasion and metastasis of HCC. FC is ma...
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Article
Open AccessCurcumin- and resveratrol-co-loaded nanoparticles in synergistic treatment of hepatocellular carcinoma
Currently, systemic therapies for patients with advanced-stage hepatocellular carcinoma (HCC) rely mainly on systemic drugs. However, traditional systemic drugs have a high rate of serious adverse events, and ...
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Article
Open AccessA novel nomogram and risk classification system predicting the Ewing sarcoma: a population-based study
Ewing sarcoma (ES) is a rare disease that lacks a prognostic prediction model. This study aims to develop a nomogram and risk classification system for estimating the probability of overall survival (OS) of pa...
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Article
Open AccessImmune infiltrating cells in cholangiocarcinoma may become clinical diagnostic markers: based on bioinformatics analysis
Intrahepatic cholangiocarcinoma (ICC) is a malignant tumor originating from the secondary bile duct and its branch epithelium. Among primary liver tumors, the incidence of ICC is second only to hepatocellular ...
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Article
Open AccessThe novel interplay between CD44 standard isoform and the caspase-1/IL1B pathway to induce hepatocellular carcinoma progression
Accumulating data indicate caspase-1 (CASP1), one of the inflammatory caspases, promotes hepatocellular carcinoma (HCC) progression in tumor proliferation, invasion, EMT phenotype and sorafenib resistance. How...
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Article
Open AccessLncRNA TRG-AS1 stimulates hepatocellular carcinoma progression by sponging miR-4500 to modulate BACH1
T cell receptor gamma locus antisense RNA 1 (TRG-AS1) has been reported to involve in the progression of glioblastoma, however the role and its underlying molecular mechanism in hepatocellular carcinoma (HCC) ...
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Article
Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance
Natural killer (NK) cells have crucial roles in tumor surveillance. We found that tumor-infiltrating NK cells in human liver cancers had small, fragmented mitochondria in their cytoplasm, whereas liver NK cell...
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Article
Choice between different operative techniques on cavernous hepatic hemangiomas
To investigate the optimizing of operative techniques on cavernous hepatic hemangioma by comparing the effective of the two approaches (enucleation and hepatectomy).
