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Article
Open AccessA Clinical Bacterial Dataset for Deep Learning in Microbiological Rapid On-Site Evaluation
Microbiological Rapid On-Site Evaluation (M-ROSE) is based on smear staining and microscopic observation, providing critical references for the diagnosis and treatment of pulmonary infectious disease. Automati...
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Article
Open AccessINHBA(+) cancer-associated fibroblasts generate an immunosuppressive tumor microenvironment in ovarian cancer
Effective targeting of cancer-associated fibroblasts (CAFs) is hindered by the lack of specific biomarkers and a poor understanding of the mechanisms by which different populations of CAFs contribute to cancer...
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Article
Open AccessEFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death
TNF acts as one pathogenic driver for inducing intestinal epithelial cell (IEC) death and substantial intestinal inflammation. How the IEC death is regulated to physiologically prevent intestinal inflammation ...
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Chapter
Distributed Multi-agent Meta-Learning for Trajectory Design in Wireless Drone Networks
In this chapter, we introduce a value decomposition-based reinforcement learning (RL) coupled with a meta training mechanism which allows RL agents to dynamically learn their policies while generalizing their ...
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Article
Open AccessLysine methyltransferase SMYD2 inhibits antiviral innate immunity by promoting IRF3 dephosphorylation
Phosphorylation of IRF3 is critical to induce type I interferon (IFN-I) production in antiviral innate response. Here we report that lysine methyltransferase SMYD2 inhibits the expressions of IFN-I and proinfl...
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Article
Sentiment deviations in responses to movie trailers across social media platforms
Social media listening has become an integral part of many companies marketing strategies. Using a unique dataset of social media comments to 413 movie trailers, we document the systematic differences in senti...
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Article
Open AccessProtocol of a multicenter, single-blind, randomized, parallel controlled trial evaluating the effect of microbiological rapid on-site evaluation (M-ROSE) guiding anti-infection treatment in patients with severe hospital-acquired pneumonia
The mortality rate of hospitalized patients with severe hospital-acquired pneumonia (SHAP) remains high. Empirical broad-spectrum antibiotic coverage and the misuse of high-grade antibiotics could lead to the ...
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Article
Open AccessNormal-weight visceral obesity promotes a higher 10-year atherosclerotic cardiovascular disease risk in patients with type 2 diabetes mellitus–a multicenter study in China
Visceral obesity is associated with high cardiovascular events risk in type 2 diabetes mellitus (T2DM). Whether normal-weight visceral obesity will pose a higher atherosclerotic cardiovascular disease (ASCVD) ...
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Chapter and Conference Paper
Thermal Characteristics Analysis of Airship Based on Multi-node Model
One-dimensional thermal model of stratospheric airship based on multi-nodes division is established in this paper. The variation law of temperatures at nodes which include solar cells, the upper skin covered b...
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Article
Open AccessInnate immune imprints in SARS-CoV-2 Omicron variant infection convalescents
SARS-CoV-2 Omicron variant infection generally gives rise to asymptomatic to moderate COVID-19 in vaccinated people. The immune cells can be reprogrammed or “imprinted” by vaccination and infections to generat...
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Article
Open AccessDisease profile and plasma neutralizing activity of post-vaccination Omicron BA.1 infection in Tian**, China: a retrospective study
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Article
Open AccessBA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages BA.2.12.1, BA.4 and BA.5 exhibit higher transmissibility than the BA.2 lineage1. The receptor binding and immune-evasion capability...
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Article
A novel mutant PIK3R1EY451delinsD breast cancer patient resistant to HER2-targeted therapy treated with everolimus: a case report
Resistance to HER2-targeted therapy is a critical issue in breast cancer that must be addressed immediately. PIK3R1 mutations are more common in Chinese breast cancer patients (17%, 25/147, Fudan University Sh...
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Article
Open AccessA novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing
Multiple myeloma (MM) is an incurable plasma cell malignancy in the bone marrow (BM), while immunoglobulin D type of MM (IgD MM) is a very rare but most severe subtype in all MM cases. Therefore, systemic stud...
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Article
Open AccessPotential roles of vitamin D binding protein in attenuating liver injury in sepsis
In sepsis, vitamin D binding protein (VDBP) has been shown to be low-expressed. The current study examined the relationship between serum VDBP level and liver injury in sepsis patients, as well as in a mouse m...
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Article
SIRT7 interacts with TEK (TIE2) to promote adriamycin induced metastasis in breast cancer
Emerging evidence suggests that cytotoxic therapy may promote drug resistance and metastasis while inhibiting the growth of primary tumors. As yet, however, the underlying mechanisms remain unclear. Here, we a...
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Article
Open AccessTMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway
Transmembrane protein (TMEM) is a family of protein that spans cytoplasmic membranes and allows cell–cell and cell–environment communication. Dysregulation of TMEMs has been observed in multiple cancers. Howev...
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Article
Open AccessLPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome
Extracellular vesicles (EVs) have emerged as important vectors of intercellular dialogue. High mobility group box protein 1 (HMGB1) is a typical damage-associated molecular pattern (DAMP) molecule, which is cy...
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Article
The value of the Demetics ultrasound-assisted diagnosis system in the differential diagnosis of benign from malignant thyroid nodules and analysis of the influencing factors
To evaluate the value of Demetics and to explore whether Demetics can help radiologists with varying years of experience in the differential diagnosis of benign from malignant thyroid nodules.
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Article
Antineoplastic Effects and Mechanisms of a New RGD Chimeric Peptide from Bullfrog Skin on the Proliferation and Apoptosis of B16F10 Cells
Malignant melanoma, an increasingly common form of skin cancer, poses a significant threat to public health, especially when the disease progresses past skin lesions to the stage of advanced metastasis. In thi...
