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Article
Open AccessEFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death
TNF acts as one pathogenic driver for inducing intestinal epithelial cell (IEC) death and substantial intestinal inflammation. How the IEC death is regulated to physiologically prevent intestinal inflammation ...
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Article
Open AccessLysine methyltransferase SMYD2 inhibits antiviral innate immunity by promoting IRF3 dephosphorylation
Phosphorylation of IRF3 is critical to induce type I interferon (IFN-I) production in antiviral innate response. Here we report that lysine methyltransferase SMYD2 inhibits the expressions of IFN-I and proinfl...
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Article
Open AccessInnate immune imprints in SARS-CoV-2 Omicron variant infection convalescents
SARS-CoV-2 Omicron variant infection generally gives rise to asymptomatic to moderate COVID-19 in vaccinated people. The immune cells can be reprogrammed or “imprinted” by vaccination and infections to generat...
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Article
Open AccessDisease profile and plasma neutralizing activity of post-vaccination Omicron BA.1 infection in Tian**, China: a retrospective study
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Article
Open AccessBA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages BA.2.12.1, BA.4 and BA.5 exhibit higher transmissibility than the BA.2 lineage1. The receptor binding and immune-evasion capability...
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Article
Structural analysis and in vitro antitumor effect of polysaccharides from Pholiota adiposa
Pholiota adiposa is an edible chestnut mushroom with many health benefits, such as antioxidant and anticancer activity. In this paper, polysaccharides were extracted from Pholidota adiposa using an acid extracti...
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Article
Open AccessChromatin remodeler ARID1A binds IRF3 to selectively induce antiviral interferon production in macrophages
Transcription factor IRF3 is critical for the induction of antiviral type I interferon (IFN-I). The epigenetic regulation of IFN-I production in antiviral innate immunity needs to be further identified. Here, ...
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Chapter and Conference Paper
The Structural Technology and Architecture of Timber Bridges in Song Dynasty Paintings
The construction of Timber Bridges in ancient China reached a peak during the Song Dynasty. The structural technology and the architecture were advanced and well developed. This paper studies and summarizes th...
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Article
Open AccessiTRAQ-Based Quantitative Proteomic Analysis of the Inhibitory Effects of Polysaccharides from Viscum coloratum (Kom.) Nakai on HepG2 Cells
Viscum coloratum (Kom.) Nakai is one of active medicinal plants, and its active components, especially polysaccharides, have been shown to exhibit bioactivity. In this study, we examined ...
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Article
Open AccessA proteomic analysis of mushroom polysaccharide-treated HepG2 cells
The anti-tumor properties of fungal polysaccharides have gained significant recognition in Asia and tropical America. In this study, the differential expression of proteins in normal HepG2 cells and those trea...
