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Article
Open AccessClinical factors associated with the therapeutic outcome of chemotherapy in very elderly cancer patients
The purpose of this study was to detect background factors that might be associated with the therapeutic and curative outcome of chemotherapy in elderly cancer patients aged over 75 years.
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Article
Open AccessA phase II trial of small-dose bortezomib, lenalidomide and dexamethasone (sVRD) as consolidation/maintenance therapy in patients with multiple myeloma
Consolidation/maintenance therapy induces deep remission in patients with multiple myeloma (MM); however, the most suitable regimen has been under investigation. The combination therapy with bortezomib, lenali...
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Article
A new once-a-day fentanyl citrate patch (Fentos® Tape) could be a new treatment option in patients with end-of-dose failure using a 72-h transdermal fentanyl matrix patch
The recommended dosing interval for transdermal fentanyl is every 72 h. However, some patients will have “end-of-dose failure,” which may be seen as an increase of episodes of severe pain flares at the third d...
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Article
Effect of duloxetine in Japanese patients with chemotherapy-induced peripheral neuropathy: a pilot randomized trial
Chemotherapy-induced peripheral neuropathy (CIPN) is difficult to manage. A phase III trial conducted in the United States demonstrated that duloxetine was effective for CIPN caused by taxane and platinum-base...
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Article
Long-term survey of survival time, histological transformation, and secondary malignancies in Japanese patients with advanced-stage follicular lymphoma in the rituximab era: Hokkaido Hematology Study Group
Following the introduction of rituximab, the long-term overall survival (OS) rate of advanced-stage follicular lymphoma (FL) cases was expected to improve after the introduction of rituximab: however, there is...
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Article
A retrospective clinical analysis of Japanese patients with peripheral T-cell lymphoma not otherwise specified: Hokkaido Hematology Study Group
Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) comprises a group of heterogeneous lymphomas that do not fit any other identified PTCL-subgroup and show poor prognosis. To clarify clinical aspect...
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Article
Epidemiology and treatment outcome of invasive fungal infections in patients with hematological malignancies
Invasive fungal infection (IFI) causes morbidity and mortality among patients with hematological malignancies who receive cytotoxic chemotherapy or hematopoietic stem cell transplantation (HSCT). We evaluated ...
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Article
Correction: Corrigendum: Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia
Nat. Med. 9, 1158–1165 (2003) Two sentences in this article appeared incorrectly. On page 1164, in the eighth paragraph, the third sentence should read “To the U937-transplanted SCID mice, 1 mg of either SG/17...
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Article
Recovery of Neutrophil Count by Ganciclovir in Patients with Chronic Idiopathic Neutropenia Associated with Cytomegalovirus Infection in Bone Marrow Stromal Cells
Patients with chronic idiopathic neutropenia (CIN) usually show chronic inflammation in their bone marrow stromal cells, but the etiologies of this disorder are still unknown. We suspected viral infection of t...
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Article
Allogeneic bone marrow transplantation in a patient with T-prolymphocytic leukemia with small-intestinal involvement
Although T-prolymphocytic leukemia (T-PLL) is characterized by organ infiltration, small-intestinal involvement is rare. We performed an unrelated allogeneic bone marrow transplantation in a patient with T-PLL...
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Article
Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia
Bone-marrow minimal residual disease (MRD) causes relapse after chemotherapy in patients with acute myelogenous leukemia (AML). We postulate that the drug resistance is induced by the attachment of very late a...
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Article
Fatality Caused by Self-Bloodletting in a Patient with Factitious Anemia
Death by bloodletting among patients with factitious anemia has never been reported to our knowledge.We report the first known case. A 25-year-old woman with severe iron deficiency anemia confessed her habit o...
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Article
Cyclic Platelet and Leukocyte Count Oscillation in Chronic Myelocytic Leukemia Regulated by the Negative Feedback of Transforming Growth Factor β
We report a case of chronic myelocytic leukemia (CML) with cyclic oscillation of platelet and leukocyte counts and attempt to elucidate the oscillatory mechanism from the standpoint of cytokine regulation of h...
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Article
A Pleural Effusion Caused by Fibrous Hematopoietic Tumor Successfully Treated With Prednisolone in a Patient With Agnogenic Myeloid Metaplasia With Myelofibrosis
A 46-year-old woman suffering from agnogenic myeloid metaplasia (AMM) since 1994 was being followed as an outpatient. In November 1999, she exhibited respiratory failure caused by massive pulmonary effusion, w...
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Article
Long-Term Survival and Late-Onset Complications of Cancer Patients Treated With High-Dose Chemotherapy Followed by Autologous Peripheral Blood Stem Cell Transplantation
The antitumor effect of high-dose chemotherapy (HDC) followed by autologous peripheral blood stem cell transplantation (auto-PBSCT) is considered superior to that of conventional chemotherapy. However, the lon...
