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Article
Coefficient of variation of T2-weighted MRI may predict the prognosis of malignant peripheral nerve sheath tumor
We investigated whether non-enhancement MRI features, including measurement of the heterogeneity of the tumor with MR T2 imaging by calculating coefficient of variation (CV) values, were associated with the pr...
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Article
Open AccessImproved EEG-based emotion recognition through information enhancement in connectivity feature map
Electroencephalography (EEG), despite its inherited complexity, is a preferable brain signal for automatic human emotion recognition (ER), which is a challenging machine learning task with emerging application...
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Article
Synergistic antitumor effect of histone deacetylase class IIa inhibitor with lenvatinib in hepatocellular carcinoma
Histone deacetylase (HDAC) class I and IIa are highly expressed in hepatocellular carcinoma (HCC) and associated with decreased survival. However, clinically used pan and class I inhibitors have serious advers...
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Article
A systemic apolipoprotein A-IV-associated amyloidosis confirmed by proteome analysis
Amyloidosis is induced by extracellular deposition of certain proteins. Thirty-six proteins have so far been identified as amyloidogenic proteins in humans. Although it is very important to determine the speci...
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Article
Survival benefit of conversion surgery after intensive chemotherapy for unresectable metastatic gastric cancer: a propensity score-matching analysis
The clinical benefit of conversion surgery (CS) for unresectable gastric cancer (GC), whereby unresectable GC responds to chemotherapy and subsequently receives curative-intent surgery, remains unclear. Here, ...
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Article
Open AccessMUTYH is associated with hepatocarcinogenesis in a non-alcoholic steatohepatitis mouse model
Non-alcoholic steatohepatitis (NASH)-related HCC is associated with oxidative stress. However, the mechanisms underlying the development of NASH-related HCC is unclear. MUTYH is one of the enzymes that is invo...
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Article
Pancreatic cancer with leptomeningeal carcinomatosis: case report and literature review
Leptomeningeal carcinomatosis (LMC) associated with pancreatic cancer is an extremely rare complication. Symptoms vary depending on the site of invasion and include intracranial pressure, and cranial and spina...
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Article
Six-transmembrane epithelial antigen of the prostate 1 protects against increased oxidative stress via a nuclear erythroid 2-related factor pathway in colorectal cancer
The over-expression of six-transmembrane epithelial antigen of the prostate 1 (STEAP1) underlies the pathogenesis of a large subset of human cancers. Expressed on the cancer cell surface, STEAP1 is an attracti...
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Article
Open AccessCombination of eribulin plus AKT inhibitor evokes synergistic cytotoxicity in soft tissue sarcoma cells
An activated AKT pathway underlies the pathogenesis of soft tissue sarcoma (STS), with over-expressed phosphorylated AKT (p-AKT) correlating with a poor prognosis in a subset of STS cases. Recently, eribulin, ...
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Article
Adaptive weighted fuzzy rule-based system for the risk level assessment of heart disease
Expert’s knowledge base systems are not effective as a decision-making aid for physicians in providing accurate diagnosis and treatment of heart diseases due to vagueness in information and impreciseness and u...
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Article
A case of cisplatin-refractory advanced pure seminoma showing complete remission after treatment with high-dose carboplatin plus etoposide as fourth-line salvage chemotherapy
We report the case of a patient who achieved complete remission (CR) of cisplatin-refractory metastatic pure seminoma after treatment with high-dose carboplatin and etoposide (CE) with peripheral blood stem ce...
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Article
Open AccessA phase II trial of small-dose bortezomib, lenalidomide and dexamethasone (sVRD) as consolidation/maintenance therapy in patients with multiple myeloma
Consolidation/maintenance therapy induces deep remission in patients with multiple myeloma (MM); however, the most suitable regimen has been under investigation. The combination therapy with bortezomib, lenali...
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Article
BAK is a predictive and prognostic biomarker for the therapeutic effect of docetaxel treatment in patients with advanced gastric cancer
Preoperative chemotherapy is a promising strategy for downstaging advanced gastric cancer before radical resection, although severe adverse events can occur and clinical outcomes are often unsatisfactory. To i...
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Article
Open AccessIsoform D of vascular endothelial growth factor in systemic capillary leak syndrome: a case report
Systemic capillary leak syndrome is a rare condition characterized by episodic attacks of hypovolemia due to systemic capillary hyperpermeability, which results in profound hypotension and edema. Although the ...
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Article
RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells
ST6GalNAc I is a sialyltransferase controlling the expression of sialyl-Tn antigen (STn), which is overexpressed in several epithelial cancers, including gastric cancer, and is highly correlated with cancer me...
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Article
Classification of Skeletal Wireframe Representation of Hand Gesture Using Complex-Valued Neural Network
Complex-valued neural networks (CVNNs), that allow processing complex-valued data directly, have been applied to a number of practical applications, especially in signal and image processing. In this paper, we...
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Article
Effect of duloxetine in Japanese patients with chemotherapy-induced peripheral neuropathy: a pilot randomized trial
Chemotherapy-induced peripheral neuropathy (CIPN) is difficult to manage. A phase III trial conducted in the United States demonstrated that duloxetine was effective for CIPN caused by taxane and platinum-base...
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Article
A dose-escalation study of oxaliplatin/capecitabine/irinotecan (XELOXIRI) and bevacizumab as a first-line therapy for patients with metastatic colorectal cancer
The aim of this study was to determine the recommended dose (RD) of a triweekly capecitabine, oxaliplatin, irinotecan, and bevacizumab (XELOXIRI/bevacizumab) regimen that was easier to administer than FOLFOXIR...
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Chapter and Conference Paper
GOS-IL: A Generalized Over-Sampling Based Online Imbalanced Learning Framework
Online imbalanced learning has two important characteristics: samples of one class (minority class) are under-represented in the data set and samples come to the learner online incrementally. Such a data set m...
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Article
Open AccessFilamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation
Learning and memory depend on morphological and functional changes to neural spines. Non-muscle myosin 2b regulates actin dynamics downstream of long-term potentiation induction. However, the mechanism by whic...
