22 Result(s)
within
Yan-Yi Wang
English
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Article
GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth
Here, we report the identification of GIDE, a mitochondrially located E3 ubiquitin ligase. GIDE contains a C-terminal RING finger domain, which is mostly conserved with those of the IAP family members and is r...
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Regulation of virus-triggered type I interferon signaling by cellular and viral proteins
Host pattern recognition receptors (PRRs) recognize invading viral pathogens and initiate a series of signaling cascades that lead to the expression of type I interferons (IFNs) and inflammatory cytokines. Dur...
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Article
Lysosomal membrane permeabilization is involved in curcumin-induced apoptosis of A549 lung carcinoma cells
We previously reported that curcumin inhibited lung cancer A549 cells growth and promoted cell apoptosis in vitro. In this study, we further examined the apoptosis-related parameters, including lysosomal damag...
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The E3 ubiquitin ligase MIB1 negatively regulates basal IκBα level and modulates NF-κB activation
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Article
Innate immune responses to DNA viruses
The innate immune system acts as the first line of defense against pathogens, which is also essential for initiation of adaptive immunity. Innate immune responses are initiated by pattern-recognition receptors...
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Heat shock cognate 71 (HSC71) regulates cellular antiviral response by impairing formation of VISA aggregates
In response to viral infection, RIG-I-like RNA helicases detect viral RNA and signal through the mitochondrial adapter protein VISA. VISA activation leads to rapid activation of transcription factors IRF3 and ...
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Article
Open AccessThe RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response
Recognition of viral dsRNA by Toll-like receptor 3 (TLR3) leads to induction of interferons (IFNs) and proinflammatory cytokines, and innate antiviral response. Here we identified the RNA-binding protein Mex3B...
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Open AccessThe Regulation of cGAS
The cGAS-MITA pathway of cytosolic DNA sensing plays essential roles in immune response against pathogens that contain DNA or with DNA production in their life cycles. The cGAS-MITA pathway also detects leaked...
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In vivo selection with lentiviral expression of Bcl2T69A/S70A/S87A mutant in hematopoietic stem cell-transplanted mice
Current in vivo selections for hematopoietic stem cell (HSC)-based gene therapy are drug dependent and not without risk of cytotoxicity or tumorigenesis. We developed a new in vivo selection system with the no...
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Article
Enhancing and protecting quantum correlations of a two-qubit entangled system via non-Hermitian operation
We investigate the dynamics of geometric measure of quantum discord and negativity as a measure of quantum entanglement for the system under the local non-Hermitian operation. Numerical calculations demonstrat...
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Open AccessTRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis
STAT3 is a transcription factor that plays central roles in various physiological processes and its deregulation results in serious diseases including cancer. The mechanisms on how STAT3 activity is regulated ...
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Open AccessA pneumonia outbreak associated with a new coronavirus of probable bat origin
Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1–4. Previous studi...
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Quantum Fisher information of a two-level system controlled by non-Hermitian operation under depolarization
We investigated the dynamics of quantum Fisher information for a two-level system controlled by a non-Hermitian operation under the depolarization, and the non-Hermitian operation is described by a special Ham...
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Open AccessTemporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients
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Article
Open AccessInfection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques
The 2019 novel coronavirus (SARS-CoV-2) outbreak is a major challenge for public health. SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases, with a mortality rate of ...
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Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin
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Open AccessSARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response
A novel SARS-related coronavirus (SARS-CoV-2) has recently emerged as a serious pathogen that causes high morbidity and substantial mortality. However, the mechanisms by which SARS-CoV-2 evades host immunity r...
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Article
SRP54 Negatively Regulates IFN-Beta Production and Antiviral Response by Targeting RIG-I and MDA5
During virus infection, RIG-I-like receptors (RLRs) recognize viral RNAs and recruit the adaptor protein VISA to activate downstream signaling, leading to activation of transcription factors NF-κB and IRF3, wh...
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Open AccessHistone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1
TANK-binding kinase 1 (TBK1), a core kinase of antiviral pathways, activates the production of interferons (IFNs). It has been reported that deacetylation activates TBK1; however, the precise mechanism still r...
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Open AccessSARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication
The newly emerging coronavirus SARS-CoV-2 causes severe lung disease and substantial mortality. How the virus evades host defense for efficient replication is not fully understood. In this report, we found tha...
