12 Result(s)
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Article
Open AccessTransmembrane serine protease 6, a novel target for inhibition of neuronal tumor growth
Transmembrane serine protease 6 (Tmprss6) has been correlated with the occurrence and progression of tumors, but any specific molecular mechanism linking the enzyme to oncogenesis has remained elusive thus far...
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Article
Open AccessCdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke
Ischemic stroke is associated with high mortality and morbidity rates worldwide. However, the molecular mechanisms underlying the neuronal damage incurred by stroke victims remain unclear. It has previously be...
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Article
Open AccessThe divergent effects of astrocyte ceruloplasmin on learning and memory function in young and old mice
Ceruloplasmin (CP) plays an important role in maintaining iron homeostasis. Cp gene knockout (Cp-/-) mice develop a neurodegenerative disease with aging and show iron accumulation in the brain. However, iron defi...
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Article
Open AccessAstrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells
Brain iron dysregulation associated with aging is closely related to motor and cognitive impairments in neurodegenerative diseases. The regulation of iron traffic at the blood-brain barrier (BBB) is crucial to...
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Open AccessMitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis
Ischaemic stroke is becoming the most common cerebral disease in aging populations, but the underlying molecular mechanism of the disease has not yet been fully elucidated. Increasing evidence has indicated th...
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Open AccessHepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-β induced brain damage in mice
Progressive iron accumulation in the brain and iron-induced oxidative stress are considered to be one of the initial causes of Alzheimer’s disease (AD), and modulation of brain iron level shows promise for its...
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Open AccessAstrocyte hepcidin is a key factor in LPS-induced neuronal apoptosis
Inflammatory responses involving microglia and astrocytes contribute to the pathogenesis of neurodegenerative diseases (NDs). In addition, inflammation is tightly linked to iron metabolism dysregulation. Howev...
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Article
Mitochondrial ferritin protects the murine myocardium from acute exhaustive exercise injury
Mitochondrial ferritin (FtMt) is a mitochondrially localized protein possessing ferroxidase activity and the ability to store iron. FtMt overexpression in cultured cells protects against oxidative damage by se...
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Open AccessMitochondrial ferritin, a new target for inhibiting neuronal tumor cell proliferation
Mitochondrial ferritin (FtMt) has a significant effect on the regulation of cytosolic and mitochondrial iron levels. However, because of the deficiency of iron regulatory elements (IRE) in FtMt’s gene sequence...
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Article
Sex Differences in Iron Status and Hepcidin Expression in Rats
Studies have shown that men and women exhibit significant differences regarding iron status. However, the effects of sex on iron accumulation and distribution are not well established. In this study, female an...
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Article
Identification and expression analysis of hepcidin-like cDNAs from pigeon (Columba livia)
Hepcidin is a cysteine-rich, dual-function peptide with antimicrobial activity that plays a crucial role in iron homeostasis. Here, we have identified two hepcidin-like cDNA sequences from pigeon, Columba livia. ...
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Article
Molecular analysis of increased iron status in moderately exercised rats
Although iron plays a critical role in exercise, the regulatory mechanism of iron metabolism remains poorly understood. The aims of the present study were to investigate the effects of different intensity exer...
