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Article
Open AccessSafety and efficacy of multi-target TKI combined with nivolumab in check-point inhibitor-refractory patients with advanced NSCLC: a prospective, single-arm, two-stage study
Resistance to immune checkpoint inhibitors (ICIs) represents a major unmet medical need in non-small cell lung cancer (NSCLC) patients. Vascular endothelial growth factor (VEGF) inhibition may reverse a suppre...
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Article
Open AccessDeterministic positioning and alignment of a single-molecule exciton in plasmonic nanodimer for strong coupling
Experimental realization of strong coupling between a single exciton and plasmons remains challenging as it requires deterministic positioning of the single exciton and alignment of its dipole moment with the ...
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Article
Open AccessATP6V1B1 regulates ovarian cancer progression and cisplatin sensitivity through the mTOR/autophagy pathway
Early detection and effective chemotherapy for ovarian cancer, a serious gynecological malignancy, require further progress. This study aimed to investigate the molecular mechanism of ATPase H+-Transporting V1 Su...
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Article
Identification novel mutations and phenotypic spectrum expanding in PATL2 in infertile women with IVF/ICSI failure
Abnormalities in oocyte maturation, fertilization, and early embryonic development are major causes of primary infertility in women who are undergoing IVF/ICSI attempts. Although many genetic factors responsib...
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Article
Cell-nanocarrier drug delivery system: a promising strategy for cancer therapy
Tumor targeting has been a great challenge for drug delivery systems. A number of nanotechnology-derived drug carriers have been developed for cancer treatment to improve efficacy and biocompatibility. Among t...
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Article
Effects of Fe3O4 Addition on the Oxide Scale of a Steam Generator Tube in High-Temperature Water
The current work investigated effects of Fe3O4 addition on the oxide scale of the stream generator (SG) tube in high-temperature water by using different surface analysis methods. It is found that the oxide scale...
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Article
Comprehensive Multiomics Analyses Establish the Optimal Prognostic Model for Resectable Gastric Cancer
Prognostic models based on multiomics data may provide better predictive capability than those established at the single-omics level. Here we aimed to establish a prognostic model for resectable gastric cancer...
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Article
Bi-allelic missense variants in MEI4 cause preimplantation embryonic arrest and female infertility
Preimplantation embryonic arrest is an important pathogenesis of female infertility, but little is known about the genetic factors behind this phenotype. MEI4 is an essential protein for DNA double-strand brea...
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Article
Open AccessGlobal stability and parameter analysis reinforce therapeutic targets of PD-L1-PD-1 and MDSCs for glioblastoma
Glioblastoma (GBM) is an aggressive primary brain cancer that currently has minimally effective treatments. Like other cancers, immunosuppression by the PD-L1-PD-1 immune checkpoint complex is a prominent axis...
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Article
A Novel Oral Drugs Delivery System for Borneol Based on HiCap®100 and Maltodextrin: Preparation, Characterization, and the Investigation as an Intestinal Absorption Enhancer
The objective of this study was to create a new method for delivering oral borneol (BN) drug that would improve stability. This was accomplished through microencapsulation using HiCap®100 and maltodextrin (MD), r...
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Article
Selenium-enriched Cardamine violifolia protects against sepsis-induced intestinal injury by regulating mitochondrial fusion in weaned pigs
Sepsis is a life-threatening organ dysfunction caused by the dysregulated response of the host to an infection, and treatments are limited. Recently, a novel selenium source, selenium-enriched Cardamine violifoli...
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Article
Open AccessThe effect of gonadotrophin-releasing hormone agonist versus human chorionic gonadotrophin trigger on pregnancy and neonatal outcomes in Letrozole-HMG IUI cycles
GnRHa and hCG are both used for oocyte maturation and ovulation triggering. However, GnRHa have a shorter half-life than hCG, which leads to luteal phase deficiency. Letrozole (LE) has been found to improve th...
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Article
ADGB variants cause asthenozoospermia and male infertility
Asthenozoospermia is one of the main factors leading to male infertility, but the genetic mechanisms have not been fully elucidated. Variants in the androglobin (ADGB) gene were identified in an infertile male c...
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Article
Reaction–Diffusion Modeling of E. coli Colony Growth Based on Nutrient Distribution and Agar Dehydration
The bacterial colony is a powerful experimental platform for broad biological research, and reaction–diffusion models are widely used to study the mechanisms of its formation process. However, there are still ...
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Article
Sound Recognition of Harmful Bird Species Related to Power Grid Faults Based on VGGish Transfer Learning
Bird activities threaten the safe operation of transmission lines and substations. In order to assist differentiated prevention of bird-related faults in power grid, this paper proposes a birdsong recognition ...
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Article
Open AccessLarge-scale analysis of de novo mutations identifies risk genes for female infertility characterized by oocyte and early embryo defects
Oocyte maturation arrest and early embryonic arrest are important reproductive phenotypes resulting in female infertility and cause the recurrent failure of assisted reproductive technology (ART). However, the...
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Article
Open AccessThe emergence of a virus variant: dynamics of a competition model with cross-immunity time-delay validated by wastewater surveillance data for COVID-19
We consider the dynamics of a virus spreading through a population that produces a mutant strain with the ability to infect individuals that were infected with the established strain. Temporary cross-immunity ...
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Article
Strong coupling between a plasmon mode and multiple different exciton states
Strong coupling between plasmons and multiple different exciton states (MESs) enables the creation of multiple hybrid polariton states under ambient conditions. These hybrid states possess unique optical prope...
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Article
Open AccessEvaluation of the advantages of robotic versus laparoscopic surgery in elderly patients with colorectal cancer
The incidence of colorectal cancer increases with aging. Curative-intent surgery based on a minimally invasive concept is expected to bring survival benefits to elderly patients (aged over 80 years) with color...
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Chapter and Conference Paper
The Research on the Challenges Confronted by the Combination of Virtual Reality Technology and Educational Games
As one of the key technologies of the 21st century, virtual reality technology has been widely used in the field of education, and educational games based on this technology are becoming increasingly mature. T...
