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Article
Open AccessTreatment patterns in women with postmenopausal osteoporosis using abaloparatide: a real-world observational study
Review of medical records from 173 women with osteoporosis who received abaloparatide treatment revealed that 96.0% had at least one visit for osteoporosis management and 55.5% had medication support group acc...
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Article
Open AccessOverexpression of OsNAR2.1 by OsNAR2.1 promoter increases drought resistance by increasing the expression of OsPLDα1 in rice
pOsNAR2.1:OsNAR2.1 expression could significantly increase nitrogen uptake efficiency and grain yield of rice.
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Article
Open AccessComparison of the cost-effectiveness of sequential treatment with abaloparatide in US men and women at very high risk of fractures
Osteoporotic-related fractures represent an increasing burden to patients, health care systems and society.
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Article
Open AccessCost-Effectiveness of Sequential Abaloparatide/Alendronate in Men at High Risk of Fractures in the United States
Abaloparatide (ABL) significantly increases bone mineral density in men with osteoporosis similar to what was reported in postmenopausal women with osteoporosis. The cost effectiveness of sequential treatment ...
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Article
LncRNA SNHG16 regulates RAS and NF-κB pathway-mediated NLRP3 inflammasome activation to aggravate diabetes nephropathy through stabilizing TLR4
LncRNA SNHG16 and Toll-like receptor-4 (TLR4) participate in diabetes nephropathy. This study investigated whether SNHG16 regulates diabetic renal injury (DRI) via TLR4 and its related mechanism.
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Article
Carboxymethyl cellulose-based injectable hydrogel loaded with a composite of melatonin and γ-cyclodextrin with antioxidant property for diabetic wound repair
Overproduction of reactive oxygen species is one of the important reasons of non-healing wounds, such as diabetic wounds. Melatonin is well known as an antioxidant, while the poor solubility limits its use in ...
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Article
Open AccessUbiquitination of CLIP-170 family protein restrains polarized growth upon DNA replication stress
Microtubules play a crucial role during the establishment and maintenance of cell polarity. In fission yeast cells, the microtubule plus-end tracking proteins (+TIPs) (including the CLIP-170 homologue Tip1) re...
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Article
Open AccessOutcomes post fragility fracture among members of an integrated healthcare organization
This study highlights an unmet need in osteoporosis management, suggesting that beyond bone mineral density and fracture history, gender, fracture type, and age should be considered for fracture risk assessmen...
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Article
Open AccessFerroptosis in oligodendrocyte progenitor cells mediates white matter injury after hemorrhagic stroke
Oligodendrocyte progenitor cells (OPCs) differentiate to myelin-producing mature oligodendrocytes and enwrap growing or demyelinated axons during development and post central nervous diseases. Failure of remye...
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Article
Highly active bifunctional catalyst: Constructing FeWO4-WO3 heterostructure for water and hydrazine oxidation at large current density
Develo** high performance anode catalysts for oxygen evolution reaction (OER) and hydrazine oxidation reaction (HzOR) at large current density is an efficient pathway to produce hydrogen. Herein, we synthesi...
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Article
Open AccessGenome and transcriptome analysis to understand the role diversification of cytochrome P450 gene under excess nitrogen treatment
Panax notoginseng (Burk.) F. H. Chen (P. notoginseng) is a medicinal plant. Cytochrome P450 (CYP450) monooxygenase superfamily is involved in the synthesis of a variety of plant hormones. Studies have shown that ...
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Article
Gender Disparities in Osteoporosis Screening and Management Among Older Adults
One in two women and one in four men experience an osteoporosis-related fracture in their lifetime. Related morbidity and mortality rates are higher in men versus women. Current guidelines are inconsistent in ...
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Article
Calcium functioned carboxymethylated cotton fabric for hemostatic wound dressing
Massive hemorrhage is a frequent cause of human death in the operating room and other emergency situations. Therefore, effective hemostatic wound dressings are essential to save lives. Here we show that, calci...
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Article
Open AccessCorrection to: Pharmacokinetic and Pharmacodynamic Studies of Elacestrant, A Novel Oral Selective Estrogen Receptor Degrader, in Healthy Post-Menopausal Women
Authors would like to correct the errors in table 2.
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Article
Open AccessPharmacokinetic and Pharmacodynamic Studies of Elacestrant, A Novel Oral Selective Estrogen Receptor Degrader, in Healthy Post-Menopausal Women
Advanced estrogen receptor-positive (ER+) breast cancer is currently treated with endocrine therapy. Elacestrant is a novel, nonsteroidal, selective estrogen receptor degrader with complex dose-related ER agon...
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Article
Open AccessA phase 1b study evaluating the effect of elacestrant treatment on estrogen receptor availability and estradiol binding to the estrogen receptor in metastatic breast cancer lesions using 18F-FES PET/CT imaging
Elacestrant is an oral selective estrogen receptor (ER) degrader. This phase 1b open-label, non-randomized study (RAD1901-106) was initiated to determine the effect of elacestrant on the availability of ER in ...
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Article
Facile fabrication of carboxymethyl chitosan/paraffin coated carboxymethylated cotton fabric with asymmetric wettability for hemostatic wound dressing
Achieving effective hemostasis is significant to ensure the survival of the people with acute massive bleeding in the battlefield or daily life in pre-hospital care. In this work, modified cotton fabric with a...
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Article
Ferroptosis and Its Role in Diverse Brain Diseases
Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads to oxidative stress a...
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Reference Work Entry In depth
Conceptual Hydrological Models
Conceptual hydrological models, sometimes also called gray-box models, are precipitation-runoff models built based on observed or assumed empirical relationships among different hydrological variables. They ar...
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Article
Open AccessBowel symptoms and self-care strategies of survivors in the process of restoration after low anterior resection of rectal cancer
The purpose of this research is to identify the bowel symptoms and self-care strategies for rectal cancer survivors during the recovery process following low anterior resection surgery.
