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  1. Article

    Open Access

    The early growth response protein 1-miR-30a-5p-neurogenic differentiation factor 1 axis as a novel biomarker for schizophrenia diagnosis and treatment monitoring

    To date, diagnosis of schizophrenia is still based on clinical interviews and careful observations, which is subjective and variable, and can lead to misdiagnosis and/or delay in diagnosis. As early interventi...

    S Liu, F Zhang, Y Y Shugart, L Yang, X Li, Z Liu, N Sun, C Yang… in Translational Psychiatry (2017)

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  2. No Access

    Article

    Whole-genome association analysis of treatment response in obsessive-compulsive disorder

    Up to 30% of patients with obsessive-compulsive disorder (OCD) exhibit an inadequate response to serotonin reuptake inhibitors (SRIs). To date, genetic predictors of OCD treatment response have not been system...

    H Qin, J F Samuels, Y Wang, Y Zhu, M A Grados, M A Riddle… in Molecular Psychiatry (2016)

  3. Article

    Open Access

    Common polygenic variation and risk for childhood-onset schizophrenia

    Childhood-onset schizophrenia (COS) is a rare and severe form of the disorder, with more striking abnormalities with respect to prepsychotic developmental disorders and abnormities in the brain development com...

    K Ahn, S S An, Y Y Shugart, J L Rapoport in Molecular Psychiatry (2016)

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  4. No Access

    Article

    Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS

    Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by intrusive thoughts and urges and repetitive, intentional behaviors that cause significant distress and impair functioning. The OC...

    M Mattheisen, J F Samuels, Y Wang, B D Greenberg, A J Fyer… in Molecular Psychiatry (2015)

  5. No Access

    Article

    High rate of disease-related copy number variations in childhood onset schizophrenia

    Copy number variants (CNVs) are risk factors in neurodevelopmental disorders, including autism, epilepsy, intellectual disability (ID) and schizophrenia. Childhood onset schizophrenia (COS), defined as onset b...

    K Ahn, N Gotay, T M Andersen, A A Anvari, P Gochman, Y Lee… in Molecular Psychiatry (2014)

  6. Article

    Erratum: Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder

    Correction to: Molecular Psychiatry advance online publication, 20 December 2011; doi:10.1038/mp.2011.157 Following the online publication of this article, the authors noted the following co-authors were not i...

    D T Chen, X Jiang, N Akula, Y Y Shugart, J R Wendland, C J M Steele… in Molecular Psychiatry (2013)

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  7. No Access

    Article

    Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder

    Meta-analyses of bipolar disorder (BD) genome-wide association studies (GWAS) have identified several genome-wide significant signals in European-ancestry samples, but so far account for little of the inherite...

    D T Chen, X Jiang, N Akula, Y Y Shugart, J R Wendland, C J M Steele… in Molecular Psychiatry (2013)

  8. No Access

    Article

    Association of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study

    Genetic association studies of SLC6A4 (SERT) and obsessive-compulsive disorder (OCD) have been equivocal. We genotyped 1241 individuals in 278 pedigrees from the OCD Collaborative Genetics Study for 13 single-nuc...

    E Voyiaziakis, O Evgrafov, D Li, H-J Yoon, P Tabares, J Samuels… in Molecular Psychiatry (2011)

  9. No Access

    Article

    An SNP linkage scan identifies significant Crohn's disease loci on chromosomes 13q13.3 and, in Jewish families, on 1p35.2 and 3q29

    Inflammatory bowel disease (IBD) is a complex genetic disorder of two major phenotypes, Crohn's disease (CD) and ulcerative colitis (UC), with increased risk in Ashkenazi Jews. Twelve genome-wide linkage scree...

    Y Y Shugart, M S Silverberg, R H Duerr, K D Taylor, M-H Wang, K Zarfas… in Genes & Immunity (2008)

  10. No Access

    Article

    Rare plus common SERT variants in obsessive-compulsive disorder

    M A Grados, J Samuels, Y Y Shugart, V L Willour, Y Wang, B Cullen… in Molecular Psychiatry (2007)

  11. No Access

    Article

    Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q

    Obsessive-compulsive disorder (OCD) is the tenth most disabling medical condition worldwide. Twin and family studies implicate a genetic etiology for this disorder, although specific genes have yet to be ident...

    Y Y Shugart, J Samuels, V L Willour, M A Grados, B D Greenberg… in Molecular Psychiatry (2006)

  12. Article

    Correction: Corrigendum: Abnormal cerebellar development and axonal decussation due to mutations in AHI1 in Joubert syndrome

    Nat. Genet. 36, 1008–1013 (2004). The first paragraph of the paper should read “Joubert syndrome is an autosomal recessive brain disorder. Affected individuals show weakness, abnormal breathing and eye movemen...

    R J Ferland, W Eyaid, R V Collura, L D Tully, R S Hill, D Al-Nouri… in Nature Genetics (2004)

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  13. No Access

    Article

    Maternal but not paternal transmission of 15q11–13–linked nondeletion Angelman syndrome leads to phenotypic expression

    Angelman syndrome (AS) may result from either maternally inherited deletions of chromosome 15q11–13 or from paternal uniparental disomy for chromosome 15. This is in contrast to Prader–Willi syndrome (PWS), wh...

    J. Wagstaff, J.H.M. Knoll, K.A. Glatt, Y.Y. Shugart, A. Sommer… in Nature Genetics (1992)