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  1. No Access

    Article

    Transcriptome profiling of a TGF-β-induced epithelial-to-mesenchymal transition reveals extracellular clusterin as a target for therapeutic antibodies

    Transforming growth factor (TGF)-β plays a dual role in tumorigenesis, switching from acting as a growth inhibitory tumor suppressor early in the process, to a tumor promoter in late-stage disease. Since TGF-β...

    A E G Lenferink, C Cantin, A Nantel, E Wang, Y Durocher, M Banville, B Paul-Roc… in Oncogene (2010)

  2. No Access

    Chapter and Conference Paper

    A Scalable Process for Helper-Dependent Adenoviral Vector Production Using PEI-Derived Transfection Strategy in Suspension Culture

    Helper-dependent adenoviral vector has demonstrated a high therapeutic potential; however, the poor efficiency of the actual production process hampers further large-scale clinical evaluation. In this work, we...

    E. Dormond, A. Meneses-Acosta, D. Jacob, Y. Durocher, M. Perrier… in Cells and Culture (2010)

  3. No Access

    Article

    Glioblastoma-secreted factors induce IGFBP7 and angiogenesis by modulating Smad-2-dependent TGF-β signaling

    Insulin-like growth factor-binding protein 7 (IGFBP7) is a selective biomarker of glioblastoma (GBM) vessels, strongly expressed in tumor endothelial cells and vascular basement membrane. IGFBP7 gene regulatio...

    A Pen, M J Moreno, Y Durocher, P Deb-Rinker, D B Stanimirovic in Oncogene (2008)

  4. No Access

    Chapter and Conference Paper

    Impact of Yeast Pyruvate Carboxylase on the Productivity of Animal Host Cell Lines

    Continuous cell lines are not capable of complete oxidising glucose via the TCA cycle. Recently, we presented a strategy of inverse metabolic engineering to increase the glycolytic flux into the TCA. This work...

    M. Bollatifogolin, N. Irani, A.J. Beccaria… in Animal Cell Technology Meets Genomics (2005)