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  1. No Access

    Article

    DACH1 attenuated PA-induced renal tubular injury through TLR4/MyD88/NF-κB and TGF-β/Smad signalling pathway

    Palmitic acid (PA), the major saturated fatty acid in the blood, often induces the initiation and progression of diabetic kidney disease (DKD). However, the underlying mechanism remains unclear. DACH1 is an im...

    J. Lin, B. Li, Q. Xu, Y. S. Liu, Y. L. Kang… in Journal of Endocrinological Investigation (2024)

  2. No Access

    Article

    Nerve growth factor orchestrates NGAL and matrix metalloproteinases activity to promote colorectal cancer metastasis

    Colorectal cancer (CRC) is one most cancer type of high incidence and high mortality rate. Metastasis play an important role in survival rate and life quality of colorectal cancer patients. Nerve growth factor...

    Y. Lei, X. He, H. Huang, Y. He, J. Lan, J. Yang… in Clinical and Translational Oncology (2022)

  3. No Access

    Article

    Effect of Protein Supplementation Combined With Resistance Training on Muscle Mass, Strength and Function in the Elderly: A Systematic Review and Meta-Analysis

    The loss of muscle mass, strength and function associated with increasing age has various health ramifications, including the elevated risk for falls, fractures, frailty, poor quality of life, and mortality. S...

    L. Hou, Y. Lei, X. Li, C. Huo, X. Jia, J. Yang… in The journal of nutrition, health & aging (2019)

  4. Article

    Open Access

    Role of the adipose PPARγ-adiponectin axis in susceptibility to stress and depression/anxiety-related behaviors

    Adaptive responses to stressful stimuli involving behavioral, emotional and metabolic changes are orchestrated by the nervous and endocrine systems. Adipose tissue has been recognized as a highly active metabo...

    M Guo, C Li, Y Lei, S Xu, D Zhao, X-Y Lu in Molecular Psychiatry (2017)

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  5. No Access

    Article

    EGFR-targeted mAb therapy modulates autophagy in head and neck squamous cell carcinoma through NLRX1–TUFM protein complex

    Epidermal growth factor receptor (EGFR)-targeted therapy in head and neck squamous cell carcinoma (HNSCC) patients frequently results in tumor resistance to treatment. Autophagy is an emerging underlying resis...

    Y Lei, B A Kansy, J Li, L Cong, Y Liu, S Trivedi, H Wen, J P-Y Ting, H Ouyang… in Oncogene (2016)

  6. Article

    Open Access

    An ANCCA/PRO2000-miR-520a-E2F2 regulatory loop as a driving force for the development of hepatocellular carcinoma

    Hepatocellular carcinoma (HCC) is one of the most common malignancies in Asia especially in China. We previously identified that ANCCA/PRO2000 as an important proliferation-associated protein predicted poor pr...

    J Huang, J Yang, Y Lei, H Gao, T Wei, L Luo, F Zhang, H Chen, Q Zeng, L Guo in Oncogenesis (2016)

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  7. No Access

    Article

    miR-448 negatively regulates ovarian cancer cell growth and metastasis by targeting CXCL12

    The purpose of the study is to investigate the roles of miR-448 in ovarian cancer.

    Y. Lv, Y. Lei, Y. Hu, W. Ding, C. Zhang, C. Fang in Clinical and Translational Oncology (2015)

  8. No Access

    Article

    Inhibition of ANKRD1 sensitizes human ovarian cancer cells to endoplasmic reticulum stress-induced apoptosis

    High expression of Ankyrin Repeat Domain 1 (ANKRD1) in ovarian carcinoma is associated with poor survival, and in ovarian cancer cell lines is associated with platinum resistance. Importantly, decreasing ANKRD1 e...

    Y Lei, B R Henderson, C Emmanuel, P R Harnett, A deFazio in Oncogene (2015)

  9. No Access

    Article

    Effect of Acute Gastric Electrical Stimulation on the Systemic Release of Hormones and Plasma Glucose in Dogs

    This study evaluated the effect of gastric electrical stimulation (GES) with various parameters on plasma concentrations of satiety-related peptides and glucose. GES was performed in nine healthy dogs via elec...

    J. H. **ng, Y. Lei, H. R. Ancha, R. F. Harty, J. D. Chen in Digestive Diseases and Sciences (2007)

  10. No Access

    Article

    Gastric Electrical Stimulation (GES) with Parameters for Morbid Obesity Elevates Lower Esophageal Sphincter (LES) Pressure in Conscious Dogs

    Background: Treatment of obese patients with the implantable gastric stimulator (IGS) was reported to improve reflux symptoms, independent of weight loss. We evaluated the effect of gastric electrical stimulat...

    J H **ng, Y Lei, J D Z Chen in Obesity Surgery (2005)