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  1. No Access

    Article

    Synergistic Antibacterial Activity of Meropenem and Imipenem in Combination with Diazabicyclooctane Derivatives

    The diazabicyclooctane (DBO) has emerged as the attractive motif for the development of new β-lactamase inhibitors after the clinical approval of avibactam and relebactam. We are striving at improving the lact...

    Jian Sun, Lili He, **gwen Ji, Lijuan Zhai… in Russian Journal of General Chemistry (2022)

  2. No Access

    Article

    Substituted-amidine derivatives of diazabicyclooctane as prospective β-lactamase inhibitors

    Discovery of β-lactamase inhibitors is a continuous process due to inherent capability of resistance in bacteria against existing inhibitors. Diazabicyclooctane ring is a non-β-lactam motif capable of inhibiti...

    Yuanbai Liu, **gwen Ji, Jian Sun, Lili He… in Monatshefte für Chemie - Chemical Monthly (2022)