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Article
Effect of WC-10Co-4Cr Reinforcement Amount on Wear and Corrosion Resistance of Fe-Based Amorphous Coatings
WC-10Co-4Cr/Fe-based amorphous composite coatings with different WC-10Co-4Cr powder contents (0-12 wt.%) were prepared on C45 steel by plasma spraying. The microstructure, hardness, wear resistance and corrosi...
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Article
Exploring the therapeutic potential of natural compounds modulating the endocannabinoid system in various diseases and disorders: review
Cannabinoid receptors, endogenous cannabinoids (endocannabinoids), and the enzymes involved in the biosynthesis and degradation of the endocannabinoids make up the endocannabinoid system (ECS). The components ...
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Article
Technique to match mesorectal lymph nodes imaging findings to histopathology: node-by-node comparison
Lymph node status is critical for staging rectal cancer and determining neoadjuvant therapy regimens. Establishing a matching between imaging and histopathological lymph nodes is fundamental for predicting lym...
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Article
Synthesis and β-Lactamase Inhibition Activity of Imidates of Diazabicyclooctane
A series of new imidate derivatives of avibactam (diazabicyclooctane derivative) was prepared for their prospective β-lactamase inhibition activity. The compounds (VIIa–m) were prepared through multiple synthetic...
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Article
Synergistic Antibacterial Activity of Meropenem and Imipenem in Combination with Diazabicyclooctane Derivatives
The diazabicyclooctane (DBO) has emerged as the attractive motif for the development of new β-lactamase inhibitors after the clinical approval of avibactam and relebactam. We are striving at improving the lact...
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Article
Establishment and validation of nomograms for predicting mesorectal lymph node staging and restaging
Preoperative determination of lymph node (LN) status is crucial in treatment planning for rectal cancer. This study prospectively evaluated the risk factors for lymph node metastasis (LNM) at staging and resta...
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Article
Substituted-amidine derivatives of diazabicyclooctane as prospective β-lactamase inhibitors
Discovery of β-lactamase inhibitors is a continuous process due to inherent capability of resistance in bacteria against existing inhibitors. Diazabicyclooctane ring is a non-β-lactam motif capable of inhibiti...
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Article
Simultaneous Determination of 1-Methyltryptophan and Indoleamine 2,3-Dioxygenase Biomakers of Tryptophan and Kynurenine in Mice Tumors by HPLC–MS/MS
Indoleamine 2,3-dioxygenase (IDO), an immune checkpoint protein, can cause the depletion of tryptophan (Trp) and accumulation of its metabolite of kynurenine (Kyn) in cancer cells, and generates the immunosupp...
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Article
Open AccessAssembly properties of bacterial tubulin homolog FtsZ regulated by the positive regulator protein ZipA and ZapA from Pseudomonas aeruginosa
Bacterial tubulin homolog FtsZ self-assembles into dynamic protofilaments, which forms the scaffold for the contractile ring (Z-ring) to achieve bacterial cell division. Here, we study the biochemical properti...
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Article
Molecular vaccine prepared by fusion of XCL1 to the multi-epitope protein of foot-and-mouth disease virus enhances the specific humoural immune response in cattle
Targeting antigen to dendritic cells (DCs) is a promising way to manipulate the immune response and to design prophylactic molecular vaccines. In this study, the cattle XCL1, ligand of XCR1, was fused to the t...
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Article
Influence of Chitosan on the Microstructured Au/CeO2 Catalyst: An Enhanced Catalytic Performance for CO Oxidation
In this work, a facile solvothermal method with the assistance of chitosan (CS) has been developed to prepare well-dispersed ceria core–shell nanospheres. The effects of CS on the growth mechanism and the cata...
