30 Result(s)
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Open AccessRecurrent neural network for predicting absence of heterozygosity from low pass WGS with ultra-low depth
The absence of heterozygosity (AOH) is a kind of genomic change characterized by a long contiguous region of homozygous alleles in a chromosome, which may cause human genetic disorders. However, no method of l...
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Open AccessIdentification and characterization of whole blood gene expression and splicing quantitative trait loci during early to mid-lactation of dairy cattle
Characterization of regulatory variants (e.g., gene expression quantitative trait loci, eQTL; gene splicing QTL, sQTL) is crucial for biologically interpreting molecular mechanisms underlying loci associated w...
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Open AccessGenome-wide identification and expression pattern analysis of the Aux/IAA (auxin/indole-3-acetic acid) gene family in alfalfa (Medicago sativa) and the potential functions under drought stress
Auxin/induced-3-acetic acid (Aux/IAA) is an important plant hormone that affects plant growth and resistance to abiotic stresses. Drought stress is a vital factor in reducing plant biomass yield and production...
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Open AccessIdentification of genomic characteristics and selective signals in Guizhou black goat
Guizhou black goat is one of the indigenous black goat breeds in the southwest region of Guizhou, China, which is an ordinary goat for mutton production. They are characterized by moderate body size, black coa...
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Open AccessGenome-wide identification of B-box zinc finger (BBX) gene family in Medicago sativa and their roles in abiotic stress responses
B-box (BBX) family is a class of zinc finger transcription factors (TFs) that play essential roles in regulating plant growth, development, as well as abiotic stress. However, no systematic analysis of BBX genes ...
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Open AccessGenome-wide association study reveals serovar-associated genetic loci in Riemerella anatipestifer
The disease caused by Riemerella anatipestifer (R. anatipestifer, RA) results in large economic losses to the global duck industry every year. Serovar-related genomic variation, such as the O-antigen and capsular...
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Open AccessAlterations of the gut microbiota in patients with postherpetic neuralgia
Postherpetic neuralgia (PHN) is a prevalent, intricate, and intractable form of neuropathic pain. The available evidence indicates that alterations in the gut microbiota are significant environmental determina...
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Open AccessAnalysis of acid-tolerance mechanism based on membrane microdomains in Saccharomyces cerevisiae
Saccharomyces cerevisiae has been used in the biosynthesis of acid products such as organic acids owing to its acid tolerance. Improving the acid tolerance of S. cerevisiae is beneficial for expanding its applica...
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Open AccessMolecular regulatory mechanism of key LncRNAs in subclinical mastitic cows with folic acid supplementation
Folic acid is a water-soluble B vitamin (B9), which is closely related to the body’s immune and other metabolic pathways. The folic acid synthesized by rumen microbes has been unable to meet the needs of high-...
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Open AccessEngineered Bacillus subtilis for the de novo production of 2′-fucosyllactose
The most abundant human milk oligosaccharide in breast milk, 2′-fucosyllactose (2′-FL), has been approved as an additive to infant formula due to its multifarious nutraceutical and pharmaceutical functions in ...
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Open AccessCompartmentalization and transporter engineering strategies for terpenoid synthesis
Microbial cell factories for terpenoid synthesis form a less expensive and more environment-friendly approach than chemical synthesis and extraction, and are thus being regarded as mainstream research recently...
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Effects of N-Linked Glycan on Lassa Virus Envelope Glycoprotein Cleavage, Infectivity, and Immune Response
Lassa virus (LASV) belongs to the Mammarenavirus genus (family Arenaviridae) and causes severe hemorrhagic fever in humans. The glycoprotein complex (GPC) contains eleven N-linked glycans that play essential role...
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Open AccessDesign of a novel antimicrobial peptide 1018M targeted ppGpp to inhibit MRSA biofilm formation
Methicillin-resistant staphylococcus aureus (MRSA) and its biofilm infection were considered as one of the main international health issues. There are still many challenges for treatment using traditional antibio...
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Open AccessVisual multiple cross displacement amplification for the rapid identification of S. agalactiae immediately from vaginal and rectal swabs
Streptococcus agalactiae (S. agalactiae) is an important pathogen that can lead to neonatus and mother infection. The current existing techniques for the identification of S. agalactiae are limited by accuracy, s...
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Open AccessPretreatment with probiotics ameliorate gut health and necrotic enteritis in broiler chickens, a substitute to antibiotics
Necrotic enteritis (NE) is being considered as one of the most important intestinal diseases in the recent poultry production systems, which causes huge economic losses globally. NE is caused by Clostridium perfr...
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Open AccessNew insights into the evolution and functional divergence of the CIPK gene family in Saccharum
Calcineurin B-like protein (CBL)-interacting protein kinases (CIPKs) are the primary components of calcium sensors, and play crucial roles in plant developmental processes, hormone signaling transduction, and ...
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Open AccessIntegrated analysis of lncRNAs and mRNAs reveals key trans-target genes associated with ETEC-F4ac adhesion phenotype in porcine small intestine epithelial cells
Long non-coding RNAs (lncRNAs) play crucial roles in gene regulation at the transcriptional and post-transcriptional levels. LncRNAs are belonging to a large class of transcripts with ≥200 nt in length which d...
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Open AccessSystematic analysis of gut microbiota in pregnant women and its correlations with individual heterogeneity
The woman’s gut microbiota during pregnancy may support nutrient acquisition, is associated with diseases, and has been linked to infant health. However, there is limited information on gut microbial character...
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Open AccessProbiotics mitigating subclinical necrotic enteritis (SNE) as potential alternatives to antibiotics in poultry
Subclinical necrotic enteritis (SNE) caused by Clostridium perfringens (CP), is an important disease in chickens, which causes huge economic losses by damaging the intestinal mucosa, decreasing digestion and abso...
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Open AccessVisual and rapid detection of Acinetobacter baumannii by a multiple cross displacement amplification combined with nanoparticles-based biosensor assay
The traditional microbiological methods used for detecting Acinetobacter baumannii were usually time-consuming and labor-intensive. Thus, we sought to establish a novel rapid detecting method for target pathogen....
