43 Result(s)
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Article
Open AccessRecurrent neural network for predicting absence of heterozygosity from low pass WGS with ultra-low depth
The absence of heterozygosity (AOH) is a kind of genomic change characterized by a long contiguous region of homozygous alleles in a chromosome, which may cause human genetic disorders. However, no method of l...
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Open AccessIdentification and characterization of whole blood gene expression and splicing quantitative trait loci during early to mid-lactation of dairy cattle
Characterization of regulatory variants (e.g., gene expression quantitative trait loci, eQTL; gene splicing QTL, sQTL) is crucial for biologically interpreting molecular mechanisms underlying loci associated w...
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Open AccessGenome-wide identification and expression pattern analysis of the Aux/IAA (auxin/indole-3-acetic acid) gene family in alfalfa (Medicago sativa) and the potential functions under drought stress
Auxin/induced-3-acetic acid (Aux/IAA) is an important plant hormone that affects plant growth and resistance to abiotic stresses. Drought stress is a vital factor in reducing plant biomass yield and production...
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Open AccessIdentification of genomic characteristics and selective signals in Guizhou black goat
Guizhou black goat is one of the indigenous black goat breeds in the southwest region of Guizhou, China, which is an ordinary goat for mutton production. They are characterized by moderate body size, black coa...
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Open AccessGenome-wide identification of B-box zinc finger (BBX) gene family in Medicago sativa and their roles in abiotic stress responses
B-box (BBX) family is a class of zinc finger transcription factors (TFs) that play essential roles in regulating plant growth, development, as well as abiotic stress. However, no systematic analysis of BBX genes ...
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Open AccessGenome-wide association study reveals serovar-associated genetic loci in Riemerella anatipestifer
The disease caused by Riemerella anatipestifer (R. anatipestifer, RA) results in large economic losses to the global duck industry every year. Serovar-related genomic variation, such as the O-antigen and capsular...
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Article
Open AccessAlterations of the gut microbiota in patients with postherpetic neuralgia
Postherpetic neuralgia (PHN) is a prevalent, intricate, and intractable form of neuropathic pain. The available evidence indicates that alterations in the gut microbiota are significant environmental determina...
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Open AccessAnalysis of acid-tolerance mechanism based on membrane microdomains in Saccharomyces cerevisiae
Saccharomyces cerevisiae has been used in the biosynthesis of acid products such as organic acids owing to its acid tolerance. Improving the acid tolerance of S. cerevisiae is beneficial for expanding its applica...
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Bacterial diversity in water from **feng Hot Spring in China
The **feng Hot Spring is one of the eight largest hot springs in China, which is rich in radon gas and sulphur in karst scenery. Little is known about the microbiota structure in the spring. The water was coll...
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Open AccessMolecular regulatory mechanism of key LncRNAs in subclinical mastitic cows with folic acid supplementation
Folic acid is a water-soluble B vitamin (B9), which is closely related to the body’s immune and other metabolic pathways. The folic acid synthesized by rumen microbes has been unable to meet the needs of high-...
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Article
Mesoporous silica stabilized Cu-Fe bimetallic nanozymes for total antioxidant capacity assay of fruit foods
Total antioxidant capacity (TAC) is currently considered as a vital indicator of food quality in antioxidant ability and attracts much attention for human healthcare. It is thus of great significance to realiz...
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Combinatorial metabolic engineering enables high yield production of α-arbutin from sucrose by biocatalysis
α-Arbutin has been widely used as a skin-whitening ingredient. Previously, we successfully produced α-arbutin via whole-cell biocatalysis and found that the conversion rate of sucrose to α-arbutin was low (~45...
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Open AccessEngineered Bacillus subtilis for the de novo production of 2′-fucosyllactose
The most abundant human milk oligosaccharide in breast milk, 2′-fucosyllactose (2′-FL), has been approved as an additive to infant formula due to its multifarious nutraceutical and pharmaceutical functions in ...
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Open AccessCompartmentalization and transporter engineering strategies for terpenoid synthesis
Microbial cell factories for terpenoid synthesis form a less expensive and more environment-friendly approach than chemical synthesis and extraction, and are thus being regarded as mainstream research recently...
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Article
Effects of N-Linked Glycan on Lassa Virus Envelope Glycoprotein Cleavage, Infectivity, and Immune Response
Lassa virus (LASV) belongs to the Mammarenavirus genus (family Arenaviridae) and causes severe hemorrhagic fever in humans. The glycoprotein complex (GPC) contains eleven N-linked glycans that play essential role...
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Expression profiles of genes involved in fatty acid and lipid biosynthesis in develo** seeds of Paeonia ostii
Paeonia ostii seeds were identified as novel sources of edible plant oil with a high proportion of α-linolenic acid, a type of n-3 fatty acid with many health benefits. Due to the unreliability of seed oil conten...
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Metabolic engineering for the synthesis of steviol glycosides: current status and future prospects
With the pursuit of natural non-calorie sweeteners, steviol glycosides (SGs) have become one of the most popular natural sweeteners in the market. The SGs in Stevia are a mixture of SGs synthesized from steviol (...
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Open AccessDesign of a novel antimicrobial peptide 1018M targeted ppGpp to inhibit MRSA biofilm formation
Methicillin-resistant staphylococcus aureus (MRSA) and its biofilm infection were considered as one of the main international health issues. There are still many challenges for treatment using traditional antibio...
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Open AccessVisual multiple cross displacement amplification for the rapid identification of S. agalactiae immediately from vaginal and rectal swabs
Streptococcus agalactiae (S. agalactiae) is an important pathogen that can lead to neonatus and mother infection. The current existing techniques for the identification of S. agalactiae are limited by accuracy, s...
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Open AccessPretreatment with probiotics ameliorate gut health and necrotic enteritis in broiler chickens, a substitute to antibiotics
Necrotic enteritis (NE) is being considered as one of the most important intestinal diseases in the recent poultry production systems, which causes huge economic losses globally. NE is caused by Clostridium perfr...
