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Article
Open AccessIncreased gene dosage of RFWD2 causes autistic-like behaviors and aberrant synaptic formation and function in mice
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions, communication deficits and repetitive behaviors. A study of autistic human subjects has identified RF...
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Article
Open AccessSelective enhancement of fear extinction by inhibiting neuronal adenylyl cyclase 1 (AC1) in aged mice
Adenylyl cyclase 1 (AC1) is a selective subtype of ACs, which is selectively expressed in neurons. The activation of AC1 is activity-dependent, and AC1 plays an important role in cortical excitation that contr...
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Article
The Application of Computer Technology to Clinical Practice Guideline Implementation: A Sco** Review
Implementation of clinical practice guidelines (CPG) is a complex and challenging task. Computer technology, including artificial intelligence (AI), has been explored to promote the CPG implementation. This st...
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Article
Open AccessActivation of the glutamatergic cingulate cortical-cortical connection facilitates pain in adult mice
The brain consists of the left and right cerebral hemispheres and both are connected by callosal projections. Less is known about the basic mechanism of this cortical-cortical connection and its functional imp...
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Article
Open AccessAge-related attenuation of cortical synaptic tagging in the ACC is rescued by BDNF or a TrkB receptor agonist in both sex of mice
Long-term potentiation (LTP) is a key cellular mechanism for learning and memory, and recent studies in the hippocampus found that LTP was impaired in aged animals. Previous studies of cortical LTP have focuse...
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Article
Open AccessTreatment and surveillance for non-muscle-invasive bladder cancer: a clinical practice guideline (2021 edition)
Non-muscle invasive bladder cancer (NMIBC) is a major type of bladder cancer with a high incidence worldwide, resulting in a great disease burden. Treatment and surveillance are the most important part of NIMB...
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Article
Open AccessCorrection to: Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson’s disease
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Article
Open AccessGlobal, regional, and national burden of kidney, bladder, and prostate cancers and their attributable risk factors, 1990–2019
The burden of kidney, bladder, and prostate cancers has changed in recent decades. This study aims to investigate the global and regional burden of, and attributable risk factors for genitourinary cancers duri...
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Article
Open AccessSynaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson’s disease
Parkinson’s disease (PD) is a multi-system neurodegenerative disorder. Patients with PD often suffer chronic pain. In the present study, we investigated motor, sensory and emotional changes in three different ...
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Article
Open AccessBrain-derived neurotrophic factor produced long-term synaptic enhancement in the anterior cingulate cortex of adult mice
Previous studies have demonstrated that brain-derived neurotrophic factor (BDNF) is one of the diffusible messengers for enhancing synaptic transmission in the hippocampus. Less information is available about ...
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Article
Correction to: Neuronal Adenylyl Cyclase Targeting Central Plasticity for the Treatment of Chronic Pain
A correction to this paper has been published: https://doi.org/10.1007/s13311-021-01065-y
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Article
Open AccessMultiple synaptic connections into a single cortical pyramidal cell or interneuron in the anterior cingulate cortex of adult mice
The ACC is an important brain area for the processing of pain-related information. Studies of synaptic connections within the ACC provide an understanding of basic cellular and molecular mechanisms for brain f...
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Article
Open AccessNMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice
N-Methyl-D-aspartate receptors (NMDARs) play a critical role in different forms of plasticity in the central nervous system. NMDARs are always assembled in tetrameric form, in which two GluN1 subunits and two ...
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Article
Open AccessCorrection to: Ascending noradrenergic excitation from the locus coeruleus to the anterior cingulate cortex
An amendment to this paper has been published and can be accessed via the original article.
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Article
Neuronal Adenylyl Cyclase Targeting Central Plasticity for the Treatment of Chronic Pain
Chronic pain is a major health problem and the effective treatment for chronic pain is still lacking. The recent crisis created by the overuse of opioids for pain treatment has clearly shown the need for non-a...
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Article
Open AccessAscending noradrenergic excitation from the locus coeruleus to the anterior cingulate cortex
Anterior cingulate cortex (ACC) plays important roles in sensory perception including pain and itch. Neurons in the ACC receive various neuromodulatory inputs from subcortical structures, including locus coeru...
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Article
Open AccessSex difference in synaptic plasticity in the anterior cingulate cortex of adult mice
Sex differences in certain types of pain sensitivity and emotional responses have been previously reported. Synaptic plasticity is a key cellular mechanism for pain perception and emotional regulation, includi...
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Article
Open AccessCortical potentiation induced by calcitonin gene-related peptide (CGRP) in the insular cortex of adult mice
Recent studies demonstrate that calcitonin gene-related peptide (CGRP) plays critical roles in migraine. Immunohistochemistry and in situ hybridization studies have shown that CGRP and its receptors are expres...
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Article
Open AccessNMDA Receptor Dependent Long-term Potentiation in Chronic Pain
Since the discovery of NMDA receptor (NMDAR) dependent long-term potentiation (LTP) in the hippocampus, many studies have demonstrated that NMDAR dependent LTP exists throughout central synapses, including tho...
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Article
Open AccessCharacterization of excitatory synaptic transmission in the anterior cingulate cortex of adult tree shrew
The tree shrew, as a primate-like animal model, has been used for studying high brain functions such as social emotion and spatial learning memory. However, little is known about the excitatory synaptic transm...
