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Article
Open AccessPlacental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes
Reduced insulin sensitivity (insulin resistance) is a hallmark of normal physiology in late pregnancy and also underlies gestational diabetes mellitus (GDM). We conducted transcriptomic profiling of 434 human ...
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Article
Metabolomic and genetic architecture of gestational diabetes subtypes
Physiological gestational diabetes mellitus (GDM) subtypes that may confer different risks for adverse pregnancy outcomes have been defined. The aim of this study was to characterise the metabolome and genetic...
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Article
Open AccessRefining the diagnosis of gestational diabetes mellitus: a systematic review and meta-analysis
Perinatal outcomes vary for women with gestational diabetes mellitus (GDM). The precise factors beyond glycemic status that may refine GDM diagnosis remain unclear. We conducted a systematic review and meta-an...
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Article
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes ...
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Article
Longitudinal changes in glucose during pregnancy in women with gestational diabetes risk factors
Despite recommendations to screen women with diabetes risk factors for hyperglycaemia in the first trimester, criteria for normal glucose values in early pregnancy have not been firmly established. We aimed to...
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Article
Genetic Studies of Gestational Diabetes and Glucose Metabolism in Pregnancy
In this review, we summarize studies investigating genetics of gestational diabetes mellitus (GDM) and glucose metabolism in pregnancy. We describe these studies in the context of the larger body of literature...
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Article
Augmented insulin secretory response in early pregnancy
This study aimed to examine changes in the insulin secretory response in early pregnancy, while accounting for changes in insulin sensitivity.
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Article
Early Pregnancy Biochemical Predictors of Gestational Diabetes Mellitus
Universal oral glucose tolerance-based screening is employed to identify pregnant women with gestational diabetes mellitus (GDM), as treatment of this condition decreases the risk of associated complications. ...
