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    Chapter

    A Guide to Preclinical Models of Zoster-Associated Pain and Postherpetic Neuralgia

    Reactivation of latent varicella-zoster virus (VZV) causes herpes zoster (HZ), which is commonly accompanied by acute pain and pruritus over the time course of a zosteriform rash. Although the rash and associa...

    Benjamin E. Warner, William F. Goins, Phillip R. Kramer… in Varicella-zoster Virus (2023)

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    Protocol

    Engineering HSV-1 Vectors for Gene Therapy

    Virus vectors have been employed as gene transfer vehicles for various preclinical and clinical gene therapy applications, and with the approval of Glybera (alipogene tiparvovec) as the first gene therapy prod...

    William F. Goins, Shaohua Huang, Justus B. Cohen… in Herpes Simplex Virus (2014)

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    Article

    Varicella zoster virus-induced pain and post-herpetic neuralgia in the human host and in rodent animal models

    Pain and post-herpetic neuralgia (PHN) are common and highly distressing complications of herpes zoster that remain a significant public health concern and in need of improved therapies. Zoster results from re...

    Paul R. Kinchington, William F. Goins in Journal of NeuroVirology (2011)

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    Chapter

    Neurovirulence of Herpes Simplex Virus Type 1 Accessory Gene Mutants

    A striking feature of the genome of herpes simplex virus (HSV) is that approximately half of the genes are not essential for replication of the virus in cell culture. It might be predicted that many of these a...

    Myron Levine, David J. Fink… in Pathogenicity of Human Herpesviruses due t… (1994)