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Article
Open AccessAnalysis of vascular disruption in zebrafish embryos as an endpoint to predict developmental toxicity
Inhibition of angiogenesis is an important mode of action for the teratogenic effect of chemicals and drugs. There is a gap in the availability of simple, experimental screening models for the detection of ang...
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Article
Open AccessCurated mode-of-action data and effect concentrations for chemicals relevant for the aquatic environment
Chemicals in the aquatic environment can be harmful to organisms and ecosystems. Knowledge on effect concentrations as well as on mechanisms and modes of interaction with biological molecules and signaling pat...
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Article
Open AccessMixture toxicity analysis in zebrafish embryo: a time and concentration resolved study on mixture effect predictivity
Humans and wildlife are continuously exposed to chemical mixtures. These mixtures vary in composition but typically contain hundreds of micropollutants at low concentrations. As it is not feasible to measure t...
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Article
Open AccessProspects and challenges of multi-omics data integration in toxicology
Exposure of cells or organisms to chemicals can trigger a series of effects at the regulatory pathway level, which involve changes of levels, interactions, and feedback loops of biomolecules of different types...
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Article
Open AccessComparison between transcriptomic responses to short-term stress exposures of a common Holarctic and endemic Lake Baikal amphipods
Lake Baikal is one of the oldest freshwater lakes and has constituted a stable environment for millions of years, in stark contrast to small, transient bodies of water in its immediate vicinity. A highly diver...
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Article
Open AccessFuture water quality monitoring: improving the balance between exposure and toxicity assessments of real-world pollutant mixtures
Environmental water quality monitoring aims to provide the data required for safeguarding the environment against adverse biological effects from multiple chemical contamination arising from anthropogenic diff...
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Article
Open AccessQuantification of Al2O3 nanoparticles in human cell lines applying inductively coupled plasma mass spectrometry (neb-ICP-MS, LA-ICP-MS) and flow cytometry-based methods
In order to quantify and compare the uptake of aluminum oxide nanoparticles of three different sizes into two human cell lines (skin keratinocytes (HaCaT) and lung epithelial cells (A549)), three analytical me...
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Article
Internalisation of engineered nanoparticles into mammalian cells in vitro: influence of cell type and particle properties
Cellular internalisation of industrial engineered nanoparticles is undesired and a reason for concern. Here we investigated and compared the ability of seven different mammalian cell cultures in vitro to incor...
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Article
Open AccessTungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes
Tungsten carbide (WC) and tungsten carbide cobalt (WC-Co) nanoparticles are of occupational health relevance because of the increasing usage in hard metal industries. Earlier studies showed an enhanced toxic p...
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Article
Open AccessTherapeutic and prophylactic effect of intermittent preventive anti-malarial treatment in infants (IPTi) from Ghana and Gabon
Intermittent preventive treatment in infants (IPTi) with sulphadoxine-pyrimethamine (SP) reduces the incidence of malaria episodes in young children. The exact mechanism by which the protective effect is media...
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Chapter and Conference Paper
Visualisation of the attachment, possible uptake and distribution of technical nanoparticles in cells with electron microscopy methods
Technical nanoparticles, which are much smaller than human cells, are beginning to be used in a wide variety of products. But there is little known yet about the possible impacts of released nanoparticles on t...
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Article
Open AccessMalaria incidence and efficacy of intermittent preventive treatment in infants (IPTi)
Intermittent preventive antimalarial treatment in infants (IPTi) is currently evaluated as a malaria control strategy. Among the factors influencing the extent of protection that is provided by IPTi are the tr...
