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Article
Expression of Concern to: RAGE-binding S100A8/A9 promotes the migration and invasion of human breast cancer cells through actin polymerization and epithelial–mesenchymal transition
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Article
Open AccessProMENDA: an updated resource for proteomic and metabolomic characterization in depression
Depression is a prevalent mental disorder with a complex biological mechanism. Following the rapid development of systems biology technology, a growing number of studies have applied proteomics and metabolomic...
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Article
Identification of Potential Biomarkers for Major Depressive Disorder: Based on Integrated Bioinformatics and Clinical Validation
Major depressive disorder (MDD) is a severe mental illness characterized by a lack of objective biomarkers. Mounting evidence suggests there are extensive transcriptional molecular changes in the prefrontal co...
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Article
Near-infrared fluorescence-assisted superficial inguinal lymph-node excision for low-risk penile cancer
Identification of superficial inguinal lymph nodes during low-risk penile cancer surgery using near-infrared (NIR) fluorescence to improve the accuracy of lymph-node dissection and reduce the incidence of miss...
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Article
Study on the poroelastic behaviors of the defected osteochondral unit
Osteoarthritis has become a major disease threatening human health. The mechanism of injury under fluid involvement can be studied by finite element method. However, most models only model the articular cartil...
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Article
Carbon nanotubes-reinforced polylactic acid/hydroxyapatite porous scaffolds for bone tissue engineering
In the field of bone defect repair, critical requirements for favorable cytocompatibility and optimal mechanical properties have propelled research efforts towards the development of composite materials. In th...
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Article
Open AccessReciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism
Agouti-related peptide (AgRP)-expressing and proopiomelanocortin (POMC)-expressing neurons reciprocally regulate food intake. Here, we combine non-interacting recombinases to simultaneously express functionall...
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Article
Open AccessBiomechanical response of lower limb joints to lateral wedge insoles
Lateral wedge insole (LWI) is a frequently recommended treatment option for early and midterm stages of medial knee osteoarthritis. However, studies of its effects on the lower limb joints are incomplete and i...
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Article
Integrated pathway and network analyses of metabolomic alterations in peripheral blood of patients with depression
Depression is a serious mental illness, but the molecular mechanisms of depression remain unclear. Previous research has reported metabolomic changes in the blood of patients with depression, while integrated ...
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Article
Open AccessA “safety cap” for improving hospital sanitation and reducing potential disease transmission
During endotracheal intubation, extubation, tracheotomy, and tracheotomy tube replacement, the splashed airway secretions of patients will increase the risk of transmission of SARS-CoV‐2 and many other potenti...
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Article
First pilot trial of colorectal ESD guided by a new magnetic anchor for ease of placement
In recent years, studies have demonstrated that magnetic anchor-guided endoscopic submucosal dissection (MAG-ESD) is feasible and safe and may facilitate the treatment of all difficult lesions. However, the ma...
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Article
Computational Modeling to Determine the Effect of Phenotypic Heterogeneity in Tumors on the Collective Tumor–Immune Interactions
Tumor immunotherapy aims to maintain or enhance the killing capability of CD8+ T cells to clear tumor cells. The tumor–immune interactions affect the function of CD8+ T cells. However, the effect of phenotype ...
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Article
Antibacterial hydroxyapatite coatings on titanium dental implants
Titanium and its alloys are often used as substrates for dental implants due to their excellent mechanical properties and good biocompatibility. However, their ability to bind to neighboring bone is limited du...
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Article
Multi-criteria group decision-making with cloud model and TOPSIS for alternative selection under uncertainty
A novel hybrid soft computing approach that integrates the cloud model and the Technique of Order Preference Similarity to the Ideal Solution (TOPSIS) is developed to deal with multi-criteria decision-making (...
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Article
Layered mechanical and electrical properties of porcine articular cartilage
The complex structure and composition of articular cartilage make its performance show depth-dependent characteristics, but its related parameters are not complete at present. In this study, porcine articular...
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Article
Open AccessHypoMap—a unified single-cell gene expression atlas of the murine hypothalamus
The hypothalamus plays a key role in coordinating fundamental body functions. Despite recent progress in single-cell technologies, a unified catalog and molecular characterization of the heterogeneous cell typ...
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Article
Progress in 3D printing for bone tissue engineering: a review
Effective clinical methods for large bone defects are not yet available on account of the complex intrinsic structure and mechanical characteristics of natural bone tissue. It remains a challenge to restore bo...
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Article
A fluid flow model in the lacunar-canalicular system under the pressure gradient and electrical field driven loads
The lacunar-canalicular system (LCS) is acknowledged to directly participate in bone tissue remodeling. The fluid flow in the LCS is synergic driven by the pressure gradient and electric field loads due to the...
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Article
Open AccessEffects of pharmacological treatment on metabolomic alterations in animal models of depression
Numerous studies have investigated metabolite alterations resulting from pharmacological treatment in depression models although few quantitative studies explored metabolites exhibiting constant alterations. T...
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Chapter and Conference Paper
Research and Application of PNT Information Service System Based on “End + Network + Cloud”
Driven by modern information and intelligent technology, the application of PNT system is gradually develo** from benchmark positioning and time service application to comprehensive spatio-temporal informati...
