Abstract
Titanium and its alloys are often used as substrates for dental implants due to their excellent mechanical properties and good biocompatibility. However, their ability to bind to neighboring bone is limited due to the lack of biological activity. At the same time, they show poor antibacterial ability which can easily cause bacterial infection and chronic inflammation, eventually resulting in implant failure. The preparation of composite hydroxyapatite coatings with antibacterial ability can effectively figure out these concerns. In this review, the research status and development trends of antibacterial hydroxyapatite coatings constructed on titanium and its alloys are analyzed and reviewed. This review may provide valuable reference for the preparation and application of high-performance and multi-functional dental implant coatings in the future.
Similar content being viewed by others
References
Dux K E. Implantable materials update. Clinics in Podiatric Medicine and Surgery, 2019, 36: 535–542
Bai L, Du Z, Du J, et al. A multifaceted coating on titanium dictates osteoimmunomodulation and osteo/angio-genesis towards ameliorative osseointegration. Biomaterials, 2018, 162: 154–169
Zhao Y, Sun Y H, Lan W W, et al. Self-assembled nanosheets on NiTi alloy facilitate endothelial cell function and manipulate macrophage immune response. Journal of Materials Science and Technology, 2021, 78: 110–120
Nuswantoro N F, Manjas M, Suharti N, et al. Hydroxyapatite coating on titanium alloy TTZ for increasing osseointegration and reducing inflammatory response in vivo on Rattus norvegicus Wistar rats. Ceramics International, 2021, 47(11): 16094–16100
Cho H R, Choe H C. Morphology of hydroxyapatite and Sr coatings deposited using radio frequency-magnetron sputtering method on nanotube formed Ti—6Al—4V alloy. Thin Solid Films, 2021, 735: 138893
Fathi A M, Ahmed M K, Afifi M, et al. Taking hydroxyapatite-coated titanium implants two steps forward: surface modification using graphene mesolayers and a hydroxyapatite-reinforced polymeric scaffold. ACS Biomaterials Science & Engineering, 2021, 7: 360–372
Harun W S W, Asri R I M, Alias J, et al. A comprehensive review of hydroxyapatite-based coatings adhesion on metallic biomaterials. Ceramics International, 2018, 44: 1250–1268
Zhao Y, Bai L, Sun Y, et al. Low-temperature alkali corrosion induced growth of nanosheet layers on NiTi alloy and their corrosion behavior and biological responses. Corrosion Science, 2021, 190: 109654
Weng Z M, Bai L, Liu Y L, et al. Osteogenic activity, antibacterial ability, and Ni release of Mg-incorporated Ni—Ti—O nanopore coatings on NiTi alloy. Applied Surface Science, 2019, 486: 441–451
Chen Z, Wang Z, Qiu W, et al. Overview of antibacterial strategies of dental implant materials for the prevention of peri-implantitis. Bioconjugate Chemistry, 2021, 32: 627–638
Guo C, Cui W, Wang X, et al. Poly-l-lysine/sodium alginate coating loading nanosilver for improving the antibacterial effect and inducing mineralization of dental implants. ACS Omega, 2020, 5: 10562–10571
Kiran A S K, Kizhakeyil A, Ramalingam R, et al. Drug loaded electrospun polymer/ceramic composite nanofibrous coatings on titanium for implant related infections. Ceramics International, 2019, 45: 18710–18720
Wu S, Xu J, Zou L, et al. Long-lasting renewable antibacterial porous polymeric coatings enable titanium biomaterials to prevent and treat peri-implant infection. Nature Communications, 2021, 12: 3303
Lin Q, Huang D, Du J, et al. Nano-hydroxyapatite crystal formation based on calcified TiO2 nanotube arrays. Applied Surface Science, 2019, 478: 237–246
Qiaoxia L, Yujie Z, Meng Y, et al. Hydroxyapatite/tannic acid composite coating formation based on Ti modified by TiO2 nanotubes. Colloids and Surfaces B: Biointerfaces, 2020, 196: 111304
Carrado A, Perrin-Schmitt F, Le Q V, et al. Nanoporous hydroxyapatite/sodium titanate bilayer on titanium implants for improved osteointegration. Dental Materials, 2017, 33: 321–332
Fihri A, Len C, Varma R S, et al. Hydroxyapatite: a review of syntheses, structure and applications in heterogeneous catalysis. Coordination Chemistry Reviews, 2017, 347: 48–76
Liu X, He D, Zhou Z, et al. In vitro bioactivity and antibacterial performances of atmospheric plasma sprayed c-axis preferential oriented hydroxyapatite coatings. Surface and Coatings Technology, 2021, 417: 127209
Priyadarshini B, Vijayalakshmi U. In vitro bioactivity, biocompatibility and corrosion resistance of multi-ionic (Ce/Si) co-doped hydroxyapatite porous coating on Ti—6Al—4 V for bone regeneration applications. Materials Science and Engineering C, 2021, 119: 111620
Stevanovic M, Dosic M, Jankovic A, et al. Gentamicin-loaded bioactive hydroxyapatite/chitosan composite coating electrodeposited on titanium. ACS Biomaterials Science & Engineering, 2018, 4: 3994–4007
Vu A A, Bose S. Natural antibiotic oregano in hydroxyapatite-coated titanium reduces osteoclastic bone resorption for orthopedic and dental applications. ACS Applied Materials & Interfaces, 2020, 12: 52383–52392
Bakhshandeh S, Yavari S A. Electrophoretic deposition: a versatile tool against biomaterial associated infections. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2018, 6(8): 1128–1148
Spengler C, Nolle F, Mischo J, et al. Strength of bacterial adhesion on nanostructured surfaces quantified by substrate morphometry. Nanoscale, 2019, 11: 19713–19722
Wu S, Altenried S, Zogg A, et al. Role of the surface nanoscale roughness of stainless steel on bacterial adhesion and microcolony formation. ACS Omega, 2018, 3: 6456–6464
Pranjali P, Meher M K, Raj R, et al. Physicochemical and antibacterial properties of pegylated zinc oxide nanoparticles dispersed in peritoneal dialysis fluid. ACS Omega, 2019, 4: 19255–19264
Skovdal S M, Jorgensen N P, Petersen E, et al. Ultra-dense polymer brush coating reduces Staphylococcus epidermidis biofilms on medical implants and improves antibiotic treatment outcome. Acta Biomaterialia, 2018, 76: 46–55
Fang Z, Chen J, Zhu Y, et al. High-throughput screening and rational design of biofunctionalized surfaces with optimized biocompatibility and antimicrobial activity. Nature Communications, 2021, 12: 3757
Qiao Y, ** Y, Zhang H, et al. Laser-activatable CuS nanodots to treat multidrug-resistant bacteria and release copper ion to accelerate healing of infected chronic nonhealing wounds. ACS Applied Materials & Interfaces, 2019, 11: 3809–3822
Zhang G, Wu Z, Yang Y, et al. A multifunctional antibacterial coating on bone implants for osteosarcoma therapy and enhanced osteointegration. Chemical Engineering Journal, 2022, 428: 131155
Li B, Ma J, Wang D, et al. Self-adjusting antibacterial properties of Ag-incorporated nanotubes on micro-nanostructured Ti surfaces. Biomaterials Science, 2019, 7: 4075–4087
Liu R, Memarzadeh K, Chang B, et al. Antibacterial effect of copper-bearing titanium alloy (Ti—Cu) against Streptococcus mutans and Porphyromonas gingivalis. Scientific Reports, 2016, 6: 29985
Xu N, Fu J, Zhao L, et al. Biofunctional elements incorporated nano/microstructured coatings on titanium implants with enhanced osteogenic and antibacterial performance. Advanced Healthcare Materials, 2020, 9(23): 2000681
Wang X, Yan L, Ye T, et al. Osteogenic and antiseptic nanocoating by in situ chitosan regulated electrochemical deposition for promoting osseointegration. Materials Science and Engineering C, 2019, 102: 415–426
Stanić V, Dimitrijević S, Antić-Stanković J, et al. Synthesis, characterization and antimicrobial activity of copper and zinc-doped hydroxyapatite nanopowders. Applied Surface Science, 2010, 256: 6083–6089
Karbowniczek J, Cordero-Arias L, Virtanen S, et al. Electrophoretic deposition of organic/inorganic composite coatings containing ZnO nanoparticles exhibiting antibacterial properties. Materials Science & Engineering C, 2017, 77: 780–789
Karthikeyan K, Chandraprabha M N, Hari Krishna R, et al. Optical and antibacterial activity of biogenic core—shell ZnO@TiO2 nanoparticles. Journal of the Indian Chemical Society, 2022, 99(3): 100361
Thukkaram M, Coryn R, Asadian M, et al. Fabrication of microporous coatings on titanium implants with improved mechanical, antibacterial, and cell-interactive properties. ACS Applied Materials & Interfaces, 2020, 12: 30155–30169
Sivaraj D, Vijayalakshmi K, Ganeshkumar A, et al. Tailoring Cu substituted hydroxyapatite/functionalized multiwalled carbon nanotube composite coating on 316L SS implant for enhanced corrosion resistance, antibacterial and bioactive properties. International Journal of Pharmaceutics, 2020, 590: 119946
Jugowiec D, Łukaszczyk A, Cieniek Ł, et al. Influence of the electrophoretic deposition route on the microstructure and properties of nano-hydroxyapatite/chitosan coatings on the Ti—13Nb—13Zr alloy. Surface and Coatings Technology, 2017, 324: 64–79
Chen H, Wang C, Yang X, et al. Construction of surface HA/TiO2 coating on porous titanium scaffolds and its preliminary biological evaluation. Materials Science and Engineering C, 2017, 70: 1047–1056
Fu X, Zhou X, Liu P, et al. The optimized preparation of HA/L-TiO2/D-TiO2 composite coating on porous titanium and its effect on the behavior osteoblasts. Regenerative Biomaterials, 2020, 7: 505–514
Fathyunes L, Khalil-Allafi J, Sheykholeslami S O R, et al. Biocompatibility assessment of graphene oxide—hydroxyapatite coating applied on TiO2 nanotubes by ultrasound-assisted pulse electrodeposition. Materials Science and Engineering C, 2018, 87: 10–21
Lai Y L, Lai S B, Yen S K. Paclitaxel/hydroxyapatite composite coatings on titanium alloy for biomedical applications. Materials Science and Engineering C, 2017, 79: 622–628
Fu X, Liu P, Zhao D, et al. Effects of nanotopography regulation and silicon do** on angiogenic and osteogenic activities of hydroxyapatite coating on titanium implant. International Journal of Nanomedicine, 2020, 15: 4171–4189
Shi Y Y, Li M, Liu Q, et al. Electrophoretic deposition of graphene oxide reinforced chitosan—hydroxyapatite nanocomposite coatings on Ti substrate. Journal of Materials Science: Materials in Medicine, 2016, 27: 48
Chernozem R V, Surmeneva M A, Krause B, et al. Functionalization of titania nanotubes with electrophoretically deposited silver and calcium phosphate nanoparticles: structure, composition and antibacterial assay. Materials Science and Engineering C, 2019, 97: 420–430
Horandghadim N, Khalil-Allafi J, Kaçar E, et al. Biomechanical compatibility and electrochemical stability of HA/Ta2O5 nanocomposite coating produced by electrophoretic deposition on superelastic NiTi alloy. Journal of Alloys and Compounds, 2019, 799: 193–204
Liu F, Wang X, Chen T, et al. Hydroxyapatite/silver electrospun fibers for anti-infection and osteoinduction. Journal of Advanced Research, 2020, 21: 91–102
Fu C, Zhang X, Savino K, et al. Antimicrobial silver—hydroxyapatite composite coatings through two-stage electrochemical synthesis. Surface and Coatings Technology, 2016, 301: 13–19
Erakovic S, Jankovic A, Tsui G C, et al. Novel bioactive antimicrobial lignin containing coatings on titanium obtained by electrophoretic deposition. International Journal of Molecular Sciences, 2014, 15: 12294–12322
Mokabber T, Cao H T, Norouzi N, et al. Antimicrobial electrodeposited silver-containing calcium phosphate coatings. ACS Applied Materials & Interfaces, 2020, 12: 5531–5541
Yan L, **ang Y, Yu J, et al. Fabrication of antibacterial and antiwear hydroxyapatite coatings via in situ chitosan-mediated pulse electrochemical deposition. ACS Applied Materials & Interfaces, 2017, 9: 5023–5030
Yu W Z, Zhang Y, Liu X, et al. Synergistic antibacterial activity of multi components in lysozyme/chitosan/silver/hydroxyapatite hybrid coating. Materials & Design, 2018, 139: 351–362
Ghosh R, Swart O, Westgate S, et al. Antibacterial copper—hydroxyapatite composite coatings via electrochemical synthesis. Langmuir, 2019, 35: 5957–5966
Hadidi M, Bigham A, Saebnoori E, et al. Electrophoretic-deposited hydroxyapatite—copper nanocomposite as an antibacterial coating for biomedical applications. Surface and Coatings Technology, 2017, 321: 171–179
Huang Y, Hao M, Nian X, et al. Strontium and copper co-substituted hydroxyapatite-based coatings with improved antibacterial activity and cytocompatibility fabricated by electrodeposition. Ceramics International, 2016, 42: 11876–11888
Wang Y, Yan L, Cheng R, et al. Multifunctional HA/Cu nano-coatings on titanium using PPy coordination and do** via pulse electrochemical polymerization. Biomaterials Science, 2018, 6: 575–585
Mehrvarz A, Khalil-Allafi J, Khosrowshahi A K. Biocompatibility and antibacterial behavior of electrochemically deposited hydroxyapatite/ZnO porous nanocomposite on NiTi biomedical alloy. Ceramics International, 2022, 48(11): 16326–16336
Yavas A, Güler S, Onak G, et al. Li-doped ZnO nanowires on flexible carbon fibers as highly efficient hybrid antibacterial structures. Journal of Alloys and Compounds, 2022, 891: 162010
Geuli O, Lewinstein I, Mandler D. Composition-tailoring of ZnO—hydroxyapatite nanocomposite as bioactive and antibacterial coating. ACS Applied Nano Materials, 2019, 2: 2946–2957
He X, Huang Z, Liu W, et al. Electrospun polycaprolactone/hydroxyapatite/ZnO films as potential biomaterials for application in bone-tendon interface repair. Colloids and Surfaces B: Biointerfaces, 2021, 204: 111825
Ghiyasi Y, Salahi E, Esfahani H. Synergy effect of Urtica dioica and ZnO NPs on microstructure, antibacterial activity and cytotoxicity of electrospun PCL scaffold for wound dressing application. Materials Today: Communications, 2021, 26: 102163
Manuja A, Kumar B, Kumar R, et al. Metal/metal oxide nanoparticles: toxicity concerns associated with their physical state and remediation for biomedical applications. Toxicology Reports, 2021, 8: 1970–1978
Ali A H. Experimental investigations on effects of ZnO NPS and annona muricata extract for in vitro and in vivo antibacterial activity. Materials Today: Proceedings, 2022, 57(Part 2): 527–530
Babu M M, Rao P V, Singh R K, et al. ZnO incorporated high phosphate bioactive glasses for guided bone regeneration implants: enhancement of in vitro bioactivity and antibacterial activity. Journal of Materials Research and Technology, 2021, 15: 633–646
Yazici H, Habib G, Boone K, et al. Self-assembling antimicrobial peptides on nanotubular titanium surfaces coated with calcium phosphate for local therapy. Materials Science and Engineering C, 2019, 94: 333–343
Sobolev A, Valkov A, Kossenko A, et al. Bioactive coating on Ti alloy with high osseointegration and antibacterial Ag nanoparticles. ACS Applied Materials & Interfaces, 2019, 11: 39534–39544
Thukkaram M, Coryn R, Asadian M, et al. Fabrication of microporous coatings on titanium implants with improved mechanical, antibacterial, and cell-interactive properties. ACS Applied Materials & Interfaces, 2020, 12: 30155–30169
Schwirn K, Lee W, Hillebrand R, et al. Self-ordered anodic aluminum oxide formed by H2SO4 hard anodization. ACS Nano, 2008, 2(2): 302–310
Jonasova L, Muller F A, Helebrant A, et al. Biomimetic apatite formation on chemically treated titanium. Biomaterials, 2004, 25: 1187–1194
Fazel M, Salimijazi H R, Shamanian M, et al. Osteogenic and antibacterial surfaces on additively manufactured porous Ti—6Al—4V implants: combining silver nanoparticles with hydrothermally synthesized HA nanocrystals. Materials Science and Engineering C, 2021, 120: 111745
He X, Zhang X, Wang X, et al. Review of antibacterial activity of titanium-based implants’ surfaces fabricated by micro-arc oxidation. Coatings, 2017, 7(3): 45
Shimabukuro M, Tsutsumi Y, Yamada R, et al. Investigation of realizing both antibacterial property and osteogenic cell compatibility on titanium surface by simple electrochemical treatment. ACS Biomaterials Science & Engineering, 2019, 5: 5623–5630
Yu S, Guo D, Han J, et al. Enhancing antibacterial performance and biocompatibility of pure titanium by a two-step electrochemical surface coating. ACS Applied Materials & Interfaces, 2020, 12: 44433–44446
Li B, **a X, Guo M, et al. Biological and antibacterial properties of the micro-nanostructured hydroxyapatite/chitosan coating on titanium. Scientific Reports, 2019, 9: 14052
Yilmaz E, Cakiroglu B, Gokce A, et al. Novel hydroxyapatite/graphene oxide/collagen bioactive composite coating on Ti16Nb alloys by electrodeposition. Materials Science and Engineering C, 2019, 101: 292–305
Hu H, Lin C, Lui P P Y, et al. Electrochemical deposition of hydroxyapatite with vinyl acetate on titanium implants. Journal of Biomedical Materials Research, 2003, 65A(1): 24–29
Sobolev A, Wolicki I, Kossenko A, et al. Coating formation on Ti—6Al—4V alloy by micro arc oxidation in molten salt. Materials, 2018, 11(9): 1611
Li B, Yang T, Sun R, et al. Biological and antibacterial properties of composite coatings on titanium surfaces modified by microarc oxidation and sol-gel processing. Dental Materials Journal, 2021, 40: 455–463
Ziabka M, Kiszka J, Trenczek-Zajac A, et al. Antibacterial composite hybrid coatings of veterinary medical implants. Materials Science and Engineering C, 2020, 112: 110968
Jaafar A, Hecker C, Arki P, et al. Sol-gel derived hydroxyapatite coatings for titanium implants: a review. Bioengineering, 2020, 7(4): 127
Mohammad N F, Ahmad R N, Mohd Rosli N L, et al. Sol gel deposited hydroxyapatite-based coating technique on porous titanium niobium for biomedical applications: a mini review. Materials Today: Proceedings, 2021, 41: 127–135
Azari R, Rezaie H R, Khavandi A. Investigation of functionally graded HA—TiO2 coating on Ti—6Al—4V substrate fabricated by sol-gel method. Ceramics International, 2019, 45: 17545–17555
Kazemi M, Ahangarani S, Esmailian M, et al. Investigation on the corrosion behavior and biocompatibility of Ti—6Al—4V implant coated with HA/TiN dual layer for medical applications. Surface and Coatings Technology, 2020, 397: 126044
Domínguez-Trujillo C, Peón E, Chicardi E, et al. Sol-gel deposition of hydroxyapatite coatings on porous titanium for biomedical applications. Surface and Coatings Technology, 2018, 333: 158–162
Tranquillo E, Bollino F. Surface modifications for implants lifetime extension: an overview of sol-gel coatings. Coatings, 2020, 10(6): 589
Shin D Y, Cheon K H, Song E H, et al. Fluorine-ion-releasing injectable alginate nanocomposite hydrogel for enhanced bioactivity and antibacterial property. International Journal of Biological Macromolecules, 2019, 123: 866–877
Batebi K, Abbasi Khazaei B, Afshar A. Characterization of solgel derived silver/fluor-hydroxyapatite composite coatings on titanium substrate. Surface and Coatings Technology, 2018, 352: 522–528
Bertoglio F, De Vita L, D’Agostino A, et al. Increased antibacterial and antibiofilm properties of silver nanoparticles using silver fluoride as precursor. Molecules, 2020, 25(15): 3494
Madhan Kumar A, Adesina A Y, Hussein M A, et al. PEDOT/FHA nanocomposite coatings on newly developed Ti—Nb—Zr implants: biocompatibility and surface protection against corrosion and bacterial infections. Materials Science and Engineering C, 2019, 98: 482–495
Shibata S, Suge T, Kimura T, et al. Antibacterial activity of ammonium hexafluorosilicate solution with antimicrobial agents for the prevention of dentin caries. American Journal of Dentistry, 2012, 25: 31–34
Ge X, Leng Y, Bao C, et al. Antibacterial coatings of fluoridated hydroxyapatite for percutaneous implants. Journal of Biomedical Materials Research Part A, 2010, 95: 588–599
Bi Q, Song X, Chen Y, et al. Zn—HA/Bi—HA biphasic coatings on titanium: fabrication, characterization, antibacterial and biological activity. Colloids and Surfaces B: Biointerfaces, 2020, 189: 110813
Hung K Y, Lo S C, Shih C S, et al. Titanium surface modified by hydroxyapatite coating for dental implants. Surface and Coatings Technology, 2013, 231: 337–345
Singh H, Kumar R, Prakash C, et al. HA-based coating by plasma spray techniques on titanium alloy for orthopedic applications. Materials Today: Proceedings, 2022, 50(Part 5): 612–628
Bencina M, Resnik M, Staric P, et al. Use of plasma technologies for antibacterial surface properties of metals. Molecules, 2021, 26(5): 1418
Sarkar N, Bose S. Controlled delivery of curcumin and vitamin K2 from hydroxyapatite-coated titanium implant for enhanced in vitro chemoprevention, osteogenesis, and in vivo osseointegration. ACS Applied Materials & Interfaces, 2020, 12: 13644–13656
Bai Y, Chi B X, Ma W, et al. Suspension plasma-sprayed fluoridated hydroxyapatite coatings: effects of spraying power on microstructure, chemical stability and antibacterial activity. Surface and Coatings Technology, 2019, 361: 222–230
Ke D, Vu A A, Bandyopadhyay A, et al. Compositionally graded doped hydroxyapatite coating on titanium using laser and plasma spray deposition for bone implants. Acta Biomaterialia, 2019, 84: 414–423
Ullah I, Siddiqui M A, Liu H, et al. Mechanical, biological, and antibacterial characteristics of plasma-sprayed (Sr, Zn) substituted hydroxyapatite coating. ACS Biomaterials Science & Engineering, 2020, 6: 1355–1366
Ullah I, Xu Q, Jan H U, et al. Effects of strontium and zinc substituted plasma sprayed hydroxyapatite coating on bone-like apatite layer formation and cell—material interaction. Materials Chemistry and Physics, 2022, 275: 125219
Liu T, Chen Y, Apicella A, et al. Effect of porous microstructures on the biomechanical characteristics of a root analogue implant: an animal study and a finite element analysis. ACS Biomaterials Science & Engineering, 2020, 6: 6356–6367
Wang C, Hu H, Li Z, et al. Enhanced osseointegration of titanium alloy implants with laser microgrooved surfaces and graphene oxide coating. ACS Applied Materials & Interfaces, 2019, 11: 39470–39483
Reggente M, Masson P, Dollinger C, et al. Novel alkali activation of titanium substrates to grow thick and covalently bound PMMA layers. ACS Applied Materials & Interfaces, 2018, 10: 5967–5977
Xu J, Aoki H, Kasugai S, et al. Enhancement of mineralization on porous titanium surface by filling with nano-hydroxyapatite particles fabricated with a vacuum spray method. Materials Science and Engineering C, 2020, 111: 110772
Deng B W, Bruzzaniti A, Cheng G J. Enhancement of osteoblast activity on nanostructured NiTi/hydroxyapatite coatings on additive manufactured NiTi metal implants by nanosecond pulsed laser sintering. International Journal of Nanomedicine, 2018, 13: 8217–8230
Deng B, Bruzzaniti A, Cheng G J. Enhancement of osteoblast activity on nanostructured NiTi/hydroxyapatite coatings on additive manufactured NiTi metal implants by nanosecond pulsed laser sintering. International Journal of Nanomedicine, 2018, 13: 8217–8230
Bai L, Yang Y, Mendhi J, et al. The effects of TiO2 nanotube arrays with different diameters on macrophage/endothelial cell response and ex vivo hemocompatibility. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2018, 6: 6322–6333
Xue X, Lu L, He D, et al. Antibacterial properties and cytocompatibility of Ti—20Zr—10Nb—4Ta alloy surface with Ag microparticles by laser treatment. Surface and Coatings Technology, 2021, 425: 127716
Gao A, Hang R, Bai L, et al. Electrochemical surface engineering of titanium-based alloys for biomedical application. Electrochimica Acta, 2018, 271: 699–718
Liu X, Man H C. Laser fabrication of Ag—HA nanocomposites on Ti6Al4V implant for enhancing bioactivity and antibacterial capability. Materials Science and Engineering C, 2017, 70: 1–8
Hu X, Xu R, Yu X, et al. Enhanced antibacterial efficacy of selective laser melting titanium surface with nanophase calcium phosphate embedded to TiO2 nanotubes. Biomedical Materials, 2018, 13(4): 045015
Cho H R, Choe H C. Morphology of hydroxyapatite and Sr coatings deposited using radio frequency-magnetron sputtering method on nanotube formed Ti—6Al—4V alloy. Thin Solid Films, 2021, 735: 138893
Prosolov K A, Belyavskaya O A, Bolat-Ool A A, et al. Antibacterial potential of Zn- and Cu-substituted hydroxyapatite-based coatings deposited by RF-magnetron sputtering. Journal of Physics: Conference Series, 2019, 1393: 012118
Wu J, Ueda K, Narushima T. Fabrication of Ag and Ta co-doped amorphous calcium phosphate coating films by radiofrequency magnetron sputtering and their antibacterial activity. Materials Science and Engineering C, 2020, 109: 110599
Prosolov K A, Belyavskaya O A, Linders J, et al. Glancing angle deposition of Zn-doped calcium phosphate coatings by RF magnetron sputtering. Coatings, 2019, 9(4): 220
Li B, **a X, Guo M, et al. Biological and antibacterial properties of the micro-nanostructured hydroxyapatite/chitosan coating on titanium. Scientific Reports, 2019, 9: 14052
Pang X, Zhitomirsky I. Electrodeposition of composite hydroxyapatite—chitosan films. Materials Chemistry and Physics, 2005, 94: 245–251
Palierse E, Helary C, Krafft J M, et al. Baicalein-modified hydroxyapatite nanoparticles and coatings with antibacterial and antioxidant properties. Materials Science and Engineering C, 2021, 118: 111537
Luo J, Mamat B, Yue Z, et al. Multi-metal ions doped hydroxyapatite coatings via electrochemical methods for antibacterial and osteogenesis. Colloid and Interface Science Communications, 2021, 43: 100435
Li K, Chen J, Xue Y, et al. Polymer brush grafted antimicrobial peptide on hydroxyapatite nanorods for highly effective antibacterial performance. Chemical Engineering Journal, 2021, 423: 130133
Wang Z, Mei L, Liu X, et al. Hierarchically hybrid biocoatings on Ti implants for enhanced antibacterial activity and osteogenesis. Colloids and Surfaces B: Biointerfaces, 2021, 204: 111802
Ivanova A A, Surmenev R A, Surmeneva M A, et al. Hybrid biocomposite with a tunable antibacterial activity and bioactivity based on RF magnetron sputter deposited coating and silver nanoparticles. Applied Surface Science, 2015, 329: 212–218
Surmeneva M A, Sharonova A A, Chernousova S, et al. Incorporation of silver nanoparticles into magnetron-sputtered calcium phosphate layers on titanium as an antibacterial coating. Colloids and Surfaces B: Biointerfaces, 2017, 156: 104–113
Wang M, Zhang H Y, **ang Y Y, et al. How does fluoride enhance hydroxyapatite? A theoretical understanding. Applied Surface Science, 2022, 586: 152753
Geuli O, Metoki N, Eliaz N, et al. Electrochemically driven hydroxyapatite nanoparticles coating of medical implants. Advanced Functional Materials, 2016, 26: 8003–8010
Huang D, Lin Q, Zhou Y, et al. Ag nanoparticles incorporated tannic acid/nanoapatite composite coating on Ti implant surfaces for enhancement of antibacterial and antioxidant properties. Surface and Coatings Technology, 2020, 399: 126169
Acknowledgements
This work was supported by the National Natural Science Foundation of China (Grant Nos. 12272253, 11632013, and 11902214) and the Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering (Grant Nos. 2021SX-AT008 and 2021SX-AT009). The support of the Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province (Grant No. 20220006) is also acknowledged with gratitude. Thanks to BioRender for help on some pictures.
Author information
Authors and Affiliations
Corresponding authors
Additional information
Disclosure of potential conflicts of interests
The authors declare that they have no competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Rights and permissions
About this article
Cite this article
Liao, Z., Li, J., Su, Y. et al. Antibacterial hydroxyapatite coatings on titanium dental implants. Front. Mater. Sci. 17, 230628 (2023). https://doi.org/10.1007/s11706-023-0628-x
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s11706-023-0628-x