33 Result(s)

Article

Osteocyte mitochondria regulate angiogenesis of transcortical vessels

Transcortical vessels (TCVs) provide effective communication between bone marrow vascular system and external circulation. Although osteocytes are in close contact with them, it is not clear whether osteocytes...

Peng Liao, Long Chen, Hao Zhou, Jiong Mei, Ziming Chen… in Nature Communications (2024)

Article

Mitochondrial heterogeneity in diseases

As key organelles involved in cellular metabolism, mitochondria frequently undergo adaptive changes in morphology, components and functions in response to various environmental stresses and cellular demands. P...

Long Chen, Mengnan Zhou, Hao Li, Delin Liu… in Signal Transduction and Targeted Therapy (2023)

Article

Premature aging of skeletal stem/progenitor cells rather than osteoblasts causes bone loss with decreased mechanosensation

A distinct population of skeletal stem/progenitor cells (SSPCs) has been identified that is indispensable for the maintenance and remodeling of the adult skeleton. However, the cell types that are responsible ...

Ruici Yang, Dandan Cao, **long Suo, Lingli Zhang, Chunyang Mo… in Bone Research (2023)

Article

Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation

Osteoarthritis (OA) is an age-related degenerative disease without disease-modifying therapy. The lack of aging-induced osteoarthritis models makes the discovery of therapeutic drugs more challenging. The defi...

**long Suo, Rui Shao, Ruici Yang, **ghui Wang, Zhong Zhang… in Cell Death & Disease (2023)

Article

Biomarkers of aging

Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...

Hainan Bao, Jiani Cao, Mengting Chen, Min Chen, Wei Chen… in Science China Life Sciences (2023)

Article

OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2

Bone homeostasis is maintained by the balance between osteoblastic bone formation and osteoclastic bone resorption. Dysregulation of this process leads to multiple diseases, including osteoporosis. However, th...

Qiong Zhu, Yesheng Fu, Chun-** Cui, Yi Ding… in Signal Transduction and Targeted Therapy (2023)

Article

Inhibition of miR338 rescues cleidocranial dysplasia in Runx2 mutant mice partially via the Hif1a-Vegfa axis

Haploinsufficiency of Runt-related transcription factor-2 (RUNX2) is responsible for cleidocranial dysplasia (CCD), a rare hereditary disease with a range of defects, including delayed closure of the cranial sutu...

Runze **, Hanshu Zhang, Chujiao Lin, **qiang Guo… in Experimental & Molecular Medicine (2023)

Article

The landscape of aging

Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic ...

Yusheng Cai, Wei Song, Jiaming Li, Ying **g, Chuqian Liang… in Science China Life Sciences (2022)

Article

Msx1⁺ stem cells recruited by bioactive tissue engineering graft for bone regeneration

Critical-sized bone defects often lead to non-union and full-thickness defects of the calvarium specifically still present reconstructive challenges. In this study, we show that neurotrophic supplements induce...

**anzhu Zhang, Wei Jiang, Chang **e, **nyu Wu, Qian Ren, Fei Wang… in Nature Communications (2022)

Article

TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes

The Ten-eleven translocation (TET) family of dioxygenases mediate cytosine demethylation by catalyzing the oxidation of 5-methylcytosine (5mC). TET-mediated DNA demethylation controls the proper differentiatio...

Lijun Wang, **uling You, Dengfeng Ruan, Rui Shao, Hai-Qiang Dai… in Nature Communications (2022)

Article

The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγ signaling

Osteoporosis caused by aging is characterized by reduced bone mass and accumulated adipocytes in the bone marrow cavity. How the balance between osteoblastogenesis and adipogenesis from bone marrow mesenchymal...

**long Suo, Sihai Zou, **ghui Wang, Yujiao Han, Lingli Zhang… in Bone Research (2022)

Article

Mechanical regulation of bone remodeling

Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via a balance between bone formation by osteoblasts and resorption by osteoclasts. These opposite processes allow the a...

Lijun Wang, **uling You, Lingli Zhang, Changqing Zhang, Weiguo Zou in Bone Research (2022)

Article

Correction: H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair

Rui Shao, Zhong Zhang, Zhan Xu, Huiling Ouyang, Lijun Wang, Hongwei Ouyang… in Bone Research (2021)

Article

α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation

Tri-methylation on lysine 40 of α-tubulin (α-TubK40me3) is a recently identified post-translational modification involved in mitosis and cytokinesis. However, knowledge about α-TubK40me3 in microtubule functio...

Xuan **e, Shaogang Wang, Mingyi Li, Lei Diao, **ngyu Pan… in Nature Communications (2021)

Article

H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair

Chondrocyte differentiation is a critical process for endochondral ossification, which is responsible for long bone development and fracture repair. Considerable progress has been made in understanding the tra...

Rui Shao, Zhong Zhang, Zhan Xu, Huiling Ouyang, Lijun Wang, Hongwei Ouyang… in Bone Research (2021)

Article

Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk

Wolff’s law and the Utah Paradigm of skeletal physiology state that bone architecture adapts to mechanical loads. These models predict the existence of a mechanostat that links strain induced by mechanical for...

Lijun Wang, **uling You, Sutada Lotinun, Lingli Zhang, Nan Wu… in Nature Communications (2020)