19 Result(s)

Article

Co-targeting BCL-X_L and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice

Small-cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. The dismal prognosis in SCLC is in part associated with an upregulation of BCL-2 family anti-apoptotic proteins, incl...

Sajid Khan, Patrick Kellish, Nick Connis, Dinesh Thummuri… in Cell Death Discovery (2023)

Article

Body fatness and mTOR pathway activation of breast cancer in the Women’s Circle of Health Study

Energy imbalance has an important role in breast cancer prognosis. Hyperactive mechanistic Target of Rapamycin (mTOR) pathway is associated with breast tumor growth, but the extent to which body fatness is ass...

Ting-Yuan David Cheng, Angela R. Omilian, Song Yao, Pamela V. Sanchez… in npj Breast Cancer (2020)

Article

Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding

Ji** Yang, **gyi Li, Keiichiro Suzuki, **aomeng Liu, Jun Wu… in Cell Research (2017)

Article

Visualization of aging-associated chromatin alterations with an engineered TALE system

Visualization of specific genomic loci in live cells is a prerequisite for the investigation of dynamic changes in chromatin architecture during diverse biological processes, such as cellular aging. However, c...

Ruotong Ren, Li** Deng, Yanhong Xue, Keiichiro Suzuki, Weiqi Zhang… in Cell Research (2017)

Article

Vitamin C alleviates aging defects in a stem cell model for Werner syndrome

Werner syndrome (WS) is a premature aging disorder that mainly affects tissues derived from mesoderm. We have recently developed a novel human WS model using WRN-deficient human mesenchymal stem cells (MSCs). ...

Ying Li, Weizhou Zhang, Liang Chang, Yan Han, Liang Sun, **aojun Gong… in Protein & Cell (2016)

Article

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

SIRT6 belongs to the mammalian homologs of Sir2 histone NAD⁺-dependent deacylase family. In rodents, SIRT6 deficiency leads to aging-associated degeneration of mesodermal tissues. It remains unknown whether human...

Huize Pan, Di Guan, **aomeng Liu, **gyi Li, Lixia Wang, Jun Wu… in Cell Research (2016)

Article

Characterization of a novel mouse model with genetic deletion of CD177

Neutrophils play an essential role in the innate immune response to infection. Neutrophils migrate from the vasculature into the tissue in response to infection. Recently, a neutrophil cell surface receptor, C...

Qing **e, Julia Klesney-Tait, Kathy Keck, Corey Parlet… in Protein & Cell (2015)

Article

ROR1, an embryonic protein with an emerging role in cancer biology

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR family consisting of ROR1 and ROR2. RORs contain two distinct extracellular cysteine-rich domains and one transmembrane domain. Wit...

Nicholas Borcherding, David Kusner, Guang-Hui Liu, Weizhou Zhang in Protein & Cell (2014)

Article

Inflammasomes in cancer: a double-edged sword

Chronic inflammatory responses have long been observed to be associated with various types of cancer and play decisive roles at different stages of cancer development. Inflammasomes, which are potent inducers ...

Ryan Kolb, Guang-Hui Liu, Ann M. Janowski, Fayyaz S. Sutterwala… in Protein & Cell (2014)

Article

DNA methylome: Unveiling your biological age

Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate. Notably, they succeeded in building a quantitative and reproducible model based on t...

Ming Li, Wensu Liu, Tingting Yuan, Ruijun Bai, Guang-Hui Liu… in Protein & Cell (2013)

Article

“TET-on” pluripotency

Recent studies have uncovered a specific role of TET proteins in reprogramming somatic cells to induced pluripotent stem cells, a process where O-linked β-N-acetylglucosamine transferase may play a crucial role.

** Wang, **g Qu, Min-Zu Wu, Weizhou Zhang, Guang-Hui Liu… in Cell Research (2013)

Article

Reprogramming based gene therapy for inherited red blood cell disorders

Hematopoietic stem cell transplantation remains the only curative therapy for certain genetic diseases of the hematopoietic system, including some inheritable deficiencies in red blood cells (RBC). Recent adva...

**uling Xu, **g Qu, Keiichiro Suzuki, Mo Li, Weizhou Zhang, Guang-Hui Liu… in Cell Research (2012)

Article

Non-viral iPSCs: a safe way for therapy?

Weiqi Zhang, Di Guan, **g Qu, Weizhou Zhang, Guang-Hui Liu in Protein & Cell (2012)

Article

Converted neural cells: induced to a cure?

Many neurodegenerative disorders such as Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and others often occur as a result of progressive loss of structure or function of neurons. Recently, many...

Weiqi Zhang, Shunlei Duan, Ying Li, **uling Xu, **g Qu, Weizhou Zhang… in Protein & Cell (2012)

Article

Find and replace: editing human genome in pluripotent stem cells

Genetic manipulation of human pluripotent stem cells (hPSCs) provides a powerful tool for modeling diseases and develo** future medicine. Recently a number of independent genome-editing techniques were devel...

Huize Pan, Weiqi Zhang, Weizhou Zhang, Guang-Hui Liu in Protein & Cell (2011)