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Article
Find and replace: editing human genome in pluripotent stem cells
Genetic manipulation of human pluripotent stem cells (hPSCs) provides a powerful tool for modeling diseases and develo** future medicine. Recently a number of independent genome-editing techniques were devel...
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Article
Converted neural cells: induced to a cure?
Many neurodegenerative disorders such as Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and others often occur as a result of progressive loss of structure or function of neurons. Recently, many...
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Article
Non-viral iPSCs: a safe way for therapy?
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Article
Reprogramming based gene therapy for inherited red blood cell disorders
Hematopoietic stem cell transplantation remains the only curative therapy for certain genetic diseases of the hematopoietic system, including some inheritable deficiencies in red blood cells (RBC). Recent adva...
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Article
“TET-on” pluripotency
Recent studies have uncovered a specific role of TET proteins in reprogramming somatic cells to induced pluripotent stem cells, a process where O-linked β-N-acetylglucosamine transferase may play a crucial role.
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Article
DNA methylome: Unveiling your biological age
Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate. Notably, they succeeded in building a quantitative and reproducible model based on t...
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Article
Open AccessInflammasomes in cancer: a double-edged sword
Chronic inflammatory responses have long been observed to be associated with various types of cancer and play decisive roles at different stages of cancer development. Inflammasomes, which are potent inducers ...
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Article
Open AccessROR1, an embryonic protein with an emerging role in cancer biology
Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR family consisting of ROR1 and ROR2. RORs contain two distinct extracellular cysteine-rich domains and one transmembrane domain. Wit...
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Article
Open AccessCharacterization of a novel mouse model with genetic deletion of CD177
Neutrophils play an essential role in the innate immune response to infection. Neutrophils migrate from the vasculature into the tissue in response to infection. Recently, a neutrophil cell surface receptor, C...
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Article
Open AccessSIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2
SIRT6 belongs to the mammalian homologs of Sir2 histone NAD+-dependent deacylase family. In rodents, SIRT6 deficiency leads to aging-associated degeneration of mesodermal tissues. It remains unknown whether human...
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Article
Open AccessVitamin C alleviates aging defects in a stem cell model for Werner syndrome
Werner syndrome (WS) is a premature aging disorder that mainly affects tissues derived from mesoderm. We have recently developed a novel human WS model using WRN-deficient human mesenchymal stem cells (MSCs). ...
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Article
Open AccessVisualization of aging-associated chromatin alterations with an engineered TALE system
Visualization of specific genomic loci in live cells is a prerequisite for the investigation of dynamic changes in chromatin architecture during diverse biological processes, such as cellular aging. However, c...
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Article
Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding
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Article
Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4
Obesity is a risk factor for breast cancer and also predicts poor clinical outcomes regardless of menopausal status. Contributing to the poor clinical outcomes is the suboptimal efficacy of standard therapies ...
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Chapter
IL-1 Signaling in Tumor Microenvironment
Interleukin 1 (IL-1) has long been known for its pleiotropic effects on inflammation that plays a complex, and sometimes contrasting, role in different stages of cancer development. As a major proinflammatory ...
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Article
Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling
Aiming to identify immune molecules with a novel function in cancer pathogenesis, we found the cluster of differentiation 177 (CD177), a known neutrophil antigen, to be positively correlated with relapse-free, me...
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Article
Open AccessBody fatness and mTOR pathway activation of breast cancer in the Women’s Circle of Health Study
Energy imbalance has an important role in breast cancer prognosis. Hyperactive mechanistic Target of Rapamycin (mTOR) pathway is associated with breast tumor growth, but the extent to which body fatness is ass...
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Chapter
Understanding and Targeting Human Cancer Regulatory T Cells to Improve Therapy
Regulatory T cells (Tregs) are critical in maintaining immune homeostasis under various pathophysiological conditions. A growing body of evidence demonstrates that Tregs play an important role in cancer progre...
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Article
Open AccessCo-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice
Small-cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. The dismal prognosis in SCLC is in part associated with an upregulation of BCL-2 family anti-apoptotic proteins, incl...