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Article
Open AccessA randomized study to compare oral potassium binders in the treatment of acute hyperkalemia
The KBindER (K+ Binders in Emergency Room and hospitalized patients) clinical trial is the first head-to-head evaluation of oral potassium binders (cation-exchange resins) for acute hyperkalemia therapy.
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Article
New insights into cognitive decline in chronic kidney disease
Chronic kidney disease (CKD) is known to be associated with cognitive impairment, but the mechanisms that underlie this kidney–brain connection are unclear. A recent study provides evidence that CKD is an inde...
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Article
Open AccessChronic kidney disease promotes cerebral microhemorrhage formation
Chronic kidney disease (CKD) is increasingly recognized as a stroke risk factor, but its exact relationship with cerebrovascular disease is not well-understood. We investigated the development of cerebral smal...
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Article
Open AccessSpectroscopic and deep learning-based approaches to identify and quantify cerebral microhemorrhages
Cerebral microhemorrhages (CMHs) are associated with cerebrovascular disease, cognitive impairment, and normal aging. One method to study CMHs is to analyze histological sections (5–40 μm) stained with Prussia...
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Article
Open AccessChronic Kidney Disease Increases Cerebral Microbleeds in Mouse and Man
Brain microbleeds are increased in chronic kidney disease (CKD) and their presence increases risk of cognitive decline and stroke. We examined the interaction between CKD and brain microhemorrhages (the neurop...
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Article
Gut microbial short-chain fatty acids and the risk of diabetes
A new study used genome-wide association data and Mendelian randomization to investigate associations between the gut microbiome and metabolic traits. The researchers demonstrate that host genetic variants inf...
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Article
Open AccessThe Cerebrovascular-Chronic Kidney Disease Connection: Perspectives and Mechanisms
Chronic kidney disease (CKD) is an independent risk factor for the development of cerebrovascular disease, particularly small vessel disease which can manifest in a variety of phenotypes ranging from lacunes t...
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Article
Role of Nrf2 Dysfunction in Uremia-Associated Intestinal Inflammation and Epithelial Barrier Disruption
Gut inflammation is prevalent in chronic kidney disease (CKD) and likely contributes to systemic inflammation via disruption of the epithelial tight junction with subsequent endotoxin and bacterial translocation.
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Article
Risk of chronic kidney disease after cancer nephrectomy
Partial nephrectomy preserves renal function in the long term and is currently the preferred standard of care for small renal cell carcinomas (RCCs)
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Open AccessCore histone genes of Giardia intestinalis: genomic organization, promoter structure, and expression
Giardia intestinalis is a protist found in freshwaters worldwide, and is the most common cause of parasitic diarrhea in humans. The phylogenetic position of this parasite is still much debated. Histones are small...
