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Article
Open AccessIntegrative genomics identifies SHPRH as a tumor suppressor gene in lung adenocarcinoma that regulates DNA damage response
Identification of driver mutations and development of targeted therapies has considerably improved outcomes for lung cancer patients. However, significant limitations remain with the lack of identified drivers...
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Article
Open AccessMethionine-producing tumor micro(be) environment fuels growth of solid tumors
Recent studies have uncovered the near-ubiquitous presence of microbes in solid tumors of diverse origins. Previous literature has shown the impact of specific bacterial species on the progression of cancer. W...
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Article
Open AccessExploring the microbiome of oral epithelial dysplasia as a predictor of malignant progression
A growing body of research associates the oral microbiome and oral cancer. Well-characterized clinical samples with outcome data are required to establish relevant associations between the microbiota and disea...
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Article
Open AccessAnalysis of GWAS-nominated loci for lung cancer and COPD revealed a new asthma locus
Asthma, lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are three respiratory diseases characterized by complex mechanisms underlying and genetic predispositions, with asthma having the highe...
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Article
Open AccessDistinct bronchial microbiome precedes clinical diagnosis of lung cancer
Resident microbial populations have been detected across solid tumors of diverse origins. Sequencing of the airway microbiota represents an opportunity for establishing a novel omics approach to early detectio...
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Article
Open AccessHuman placental piwi-interacting RNA transcriptome is characterized by expression from the DLK1-DIO3 imprinted region
The placenta is vital to embryonic development and requires a finely-tuned pattern of gene expression, achieved in part by its unique epigenetic landscape. Piwi-interacting RNAs (piRNAs) are a class of small-n...
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Article
Open AccessProfiling the small non-coding RNA transcriptome of the human placenta
Proper functioning of the human placenta is critical for maternal and fetal health. While microRNAs (miRNAs) are known to impact placental gene expression, the effects of other small non-coding RNAs (sncRNAs) ...
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Article
Open AccessLoss of Parkinson’s susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis
Pathological links between neurodegenerative disease and cancer are emerging. LRRK2 overactivity contributes to Parkinson’s disease, whereas our previous analyses of public cancer patient data revealed that de...
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Article
Open AccessAssessment of long non-coding RNA expression reveals novel mediators of the lung tumour immune response
The tumour immune microenvironment is a crucial mediator of lung tumourigenesis, and characterizing the immune landscape of patient tumours may guide immunotherapy treatment regimens and uncover novel interven...
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Chapter
Janus or Hydra: The Many Faces of T Helper Cells in the Human Tumour Microenvironment
CD4+ T helper (TH) cells are key regulators in the tumour immune microenvironment (TIME), mediating the adaptive immunological response towards cancer, mainly through the activation of cytotoxic CD8+ T cells. Aft...
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Article
Open AccessEpithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma
Gene function in cancer is often cell type-specific. The epithelial cell-specific transcription factor ELF3 is a documented tumor suppressor in many epithelial tumors yet displays oncogenic properties in other...
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Article
Open AccessHyperspectral cell sociology reveals spatial tumor-immune cell interactions associated with lung cancer recurrence
The tumor microenvironment (TME) is a complex mixture of tumor epithelium, stroma and immune cells, and the immune component of the TME is highly prognostic for tumor progression and patient outcome. In lung c...
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Article
Open AccessLarge-scale discovery of previously undetected microRNAs specific to human liver
MicroRNAs (miRNAs) are crucial regulators of gene expression in normal development and cellular homeostasis. While miRNA repositories contain thousands of unique sequences, they primarily contain molecules tha...
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Article
Open AccessNon-coding RNAs predict recurrence-free survival of patients with hypoxic tumours
Hypoxia promotes tumour aggressiveness and reduces patient survival. A spectrum of poor outcome among patients with hypoxic tumours suggests that additional factors modulate how tumours respond to hypoxia. PIW...
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Article
Open AccessSmall non-coding RNA transcriptome of the NCI-60 cell line panel
Only 3% of the transcribed human genome is translated into protein, and small non-coding RNAs from these untranslated regions have demonstrated critical roles in transcriptional and translational regulation of...
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Reference Work Entry In depth
Malignancy-Associated Changes
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Reference Work Entry In depth
Oral Cancer
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Article
Open AccessEmerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis
Lung cancer is a leading cause of cancer-related deaths worldwide. Lung cancer risk factors, including smoking and exposure to environmental carcinogens, have been linked to chronic inflammation. An integral f...
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Article
An atlas of gastric PIWI-interacting RNA transcriptomes and their utility for identifying signatures of gastric cancer recurrence
The poor survival and recurrence rate in gastric adenocarcinoma highlights the need for cancer gene discovery. Towards this end, we globally assessed the expression of an emerging class of small non-coding RNA...
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Article
Assessment of the clinical relevance of 17q25.3 copy number and three-dimensional telomere organization in non-small lung cancer patients
To identify potential biomarkers that may provide new therapeutic targets or prognostic indicators for non-small cell lung cancer (NSCLC), we investigated the three-dimensional (3D) organization of telomeres ...
