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  1. Article

    Open Access

    Loss of Parkinson’s susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis

    Pathological links between neurodegenerative disease and cancer are emerging. LRRK2 overactivity contributes to Parkinson’s disease, whereas our previous analyses of public cancer patient data revealed that de...

    Chandra Lebovitz, Nicole Wretham, Maryam Osooly, Katy Milne, Tia Dash… in Scientific Reports (2021)

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  2. Article

    Open Access

    Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities

    Irinotecan is a water-soluble camptothecin derivative with clinical activity against colorectal and small cell lung cancers and is currently a standard of care therapeutic in the treatment of colorectal cancer...

    Dawn N. Waterhouse, Brent W. Sutherland, Nancy Dos Santos… in Investigational New Drugs (2014)

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