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Article
Open AccessSitafloxacin reduces tumor necrosis factor alpha (TNFα) converting enzyme (TACE) phosphorylation and activity to inhibit TNFα release from lipopolysaccharide-stimulated THP-1 cells
Sepsis is a systemic reaction to an infection and resulting in excessive production of inflammatory cytokines and chemokines. It sometimes results in septic shock. The present study aimed to identify quinolone...
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Article
Open AccessSymbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon
Intestinal microbiota-derived metabolites have biological importance for the host. Polyamines, such as putrescine and spermidine, are produced by the intestinal microbiota and regulate multiple biological proc...
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Article
Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters
Zinc is an essential micronutrient for normal organ function, and dysregulation of zinc metabolism has been implicated in a wide range of diseases. Emerging evidence has revealed that zinc transporters play di...
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Article
Open AccessMast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis
Zinc (Zn) is an essential nutrient and its deficiency causes immunodeficiency and skin disorders. Various cells including mast cells release Zn-containing granules when activated; however, the biological role ...
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Article
Open AccessCritical role of endogenous histamine in promoting end-organ tissue injury in sepsis
Histamine assumes an important role as a major mediator in various pathologic disorders associated with inflammation and immune reactions. However, the involvement of histamine in the pathological conditions a...
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Article
Letter to the Editor: Backbone 1H, 13C and 15N resonance assignments for the Mg2+-bound form of the Ca2+-binding photoprotein aequorin
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Chapter
Translocation of Various Arginine-Rich Peptides and the Potential of These Peptides as Carriers for Intracellular Protein Delivery
Recently, methods have been developed for the delivery of exogenous proteins into living cells with the help of membrane-permeable carrier peptides such as HIV-1 Tat-(48–60) and Antennapedia-(43–58). By hybrid...
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Chapter
Characterization of Translocation Behavior of Arginine-Rich Membrane-Permeable Peptides
Basic peptides such as HIV-1 Tat-(48–60) and Antennapedia-(43–58) have been reported to have membrane permeability and utilized as protein carriers [1,2]. We have found that these characteristics are shared ub...