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Article
Author Correction: Failure of human rhombic lip differentiation underlies medulloblastoma formation
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Article
Failure of human rhombic lip differentiation underlies medulloblastoma formation
Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain1–4. Mutations that activate Sonic hedgehog signallin...
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Article
Open AccessInteractome and reciprocal activation of pathways in topical mesenchymal stem cells and the recipient cerebral cortex following traumatic brain injury
In this study, GFP-MSCs were topically applied to the surface of cerebral cortex within 1 hour of experimental TBI. No treatment was given to the control group. Three days after topical application, the MSCs h...
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Article
Open AccessIntravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage: an updated systemic review and meta-analysis
Previous meta-analyses of magnesium sulphate infusion in the treatment of aneurysmal subarachnoid hemorrhage (SAH) have become outdated due to recently published clinical trials. Our aim was thus to perform an...
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Article
Clinical study on cognitive dysfunction after spontaneous subarachnoid haemorrhage: patient profiles and relationship to cholinergic dysfunction
We aimed to explore the cognitive profiles of subarachnoid haemorrhage patients who returned to the community, along with the associated risk factors.
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Chapter and Conference Paper
Ischemic events after carotid interventions in relationship to baseline cerebrovascular reactivity
Background We aimed to investigate whether baseline cerebrovascular reactivity could predict subsequent ische-mic event after intervention and identify the patient group for more aggressive medic...
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Article
Open AccessLovastatin sensitized human glioblastoma cells to TRAIL-induced apoptosis
Synergy study with chemotherapeutic agents is a common in vitro strategy in the search for effective cancer therapy. For non-chemotherapeutic agents, efficacious synergistic effects are uncommon. Here, we have...
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Article
Does endoluminal coil embolization cause distension of intracranial aneurysms?
The aim of the present study was to determine whether intracranial aneurysms are distended after coil embolization and to evaluate the distensibility of ruptured aneurysms treated with endovascular coiling.
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Book and Conference Proceedings
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Chapter and Conference Paper
The role of haematoma aspiration in the management of patients with thalamic haemorrhage: a pilot study with continuous compliance monitoring
Thalamic brain haemorrhage is a common disabling and potentially fatal condition. Management is mainly supportive and very rarely do neurosurgeons have to resort to evacuation of the haematoma. We hypothesised...
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Article
Induction of Apoptosis in Glioma Cells by Molecules Released from Activated Macrophages
Macrophages play an important role in the regulation of malignant tumors. Although glioma contains abundance of macrophages, their role in apoptosis of glioma is not known. We stimulated macrophages with lipop...
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Chapter and Conference Paper
Is Transcranial Doppler Ultrasonography (TCD) Good Enough in Determining CO2 Reactivity and Pressure Autoregulation in Head-Injured Patients?
Disturbance of cerebral haemodynamic status, cerebral vasoreactivity (CVR) to carbon dioxide (CO2) and pressure autoregulatory response (PAR) have been shown to be associated with severity of head injury and to c...
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Chapter and Conference Paper
Neurochemical Changes in Ventilated Head-Injured Patients with Cerebral Perfusion Pressure Treatment Failure
The goal of intensive care management of patients with head injury is to provide them with a favourable physiological and metabolic environment for recovery of injury-compromised cells, and to prevent secondar...
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Article
Childhood posterior fossa pial–dural arteriovenous fistula treated by endovascular occlusion
Posterior fossa dural arteriovenous fistulae in children are rare lesions that are difficult to treat effectively. We report a case of a 2-year-old girl with such a fistula, who presented clinically with progr...
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Article
Features of pediatric head injury in Hong Kong
Head injury in children causes special concern in most communities. From 1989 to 1994, 2,785 children younger than 16 years old were admitted to our neurosurgical service because of head injury. Fall from a he...
