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Article
Author Correction: Failure of human rhombic lip differentiation underlies medulloblastoma formation
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Article
Failure of human rhombic lip differentiation underlies medulloblastoma formation
Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain1–4. Mutations that activate Sonic hedgehog signallin...
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Article
Unified rhombic lip origins of group 3 and group 4 medulloblastoma
Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into biologically distinct subgroups, suggesting that a personalized approach to therapy would be beneficial1. Mouse modelling and ...
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Article
Evidence of disrupted rhombic lip development in the pathogenesis of Dandy–Walker malformation
Dandy–Walker malformation (DWM) and Cerebellar vermis hypoplasia (CVH) are commonly recognized human cerebellar malformations diagnosed following ultrasound and antenatal or postnatal MRI. Specific radiologica...
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Article
Spatial and cell type transcriptional landscape of human cerebellar development
The human neonatal cerebellum is one-fourth of its adult size yet contains the blueprint required to integrate environmental cues with develo** motor, cognitive and emotional skills into adulthood. Although ...
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Article
Open AccessConsensus Paper: Cerebellar Development
The development of the mammalian cerebellum is orchestrated by both cell-autonomous programs and inductive environmental influences. Here, we describe the main processes of cerebellar ontogenesis, highlighting...
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Article
Active medulloblastoma enhancers reveal subgroup-specific cellular origins
Medulloblastoma is a highly malignant paediatric brain tumour, often inflicting devastating consequences on the develo** child. Genomic studies have revealed four distinct molecular subgroups with divergent ...
