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  1. No Access

    Article

    Self-assembling Organogels Loaded with Tenoxicam for Local Intensive Pain and Inflammation Cure: In Vitro and In Vivo Correlation

    Due to tenoxicam (TX)’s poor aqueous solubility (0.072 mg/ml), it is poorly absorbable in the GIT, and the long-term oral administration of TX may cause severe GIT disturbances. Topical administration of TX ca...

    Shaaban K. Osman, Taher M. Yassin, Arafat Abdelzaher, Fatma Ahmed… in AAPS PharmSciTech (2024)

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    Article

    A unique application of pentane-2,4-dione as a fluorogenic probe of dipeptidyl peptidase-4 enzyme inhibitor medicament assay in pharmaceutical and biological matrices>

    Sitagliptin (STG) is assigned pharmacologically as a dipeptidyl peptidase-4 enzyme inhibitor. The aforementioned drug, which is taken by mouth either alone or in conjunction with metformin, is used to manage c...

    Mohamed A. El Hamd, Bassam Shaaban Mohammed, Wael A. Mahdi… in Chemical Papers (2024)

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    Article

    A Novel Approach for the Availability and Ocular Delivery of Tenoxicam Potassium: Synthesis, Characterization, and In Vivo Application

    Tenoxicam (TX) is a non-steroidal anti-inflammatory agent that can be used to control pain in various ophthalmic lesions like cataracts, refractive surgery, and corneal abrasion. TX has a very slightly aqueous...

    Shaaban K. Osman, Taher M. Yassin, Ahmed M. Mohammed… in AAPS PharmSciTech (2023)

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    Experimental Solubility, Thermodynamic/Computational Validations, and GastroPlus-Based In Silico Prediction for Subcutaneous Delivery of Rifampicin

    We focused to explore a suitable solvent for rifampicin (RIF) recommended for subcutaneous (sub-Q) delivery [ethylene glycol (EG), propylene glycol (PG), tween 20, polyethylene glycol-400 (PEG400), oleic acid ...

    Wael A. Mahdi, Afzal Hussain, Mohammad A. Altamimi, Sultan Alshehri… in AAPS PharmSciTech (2021)

  5. Article

    Correction to: Pluronic-Coated Biogenic Gold Nanoparticles for Colon Delivery of 5-Fluorouracil: In vitro and Ex vivo Studies

    A Correction to this paper has been published: https://doi.org/10.1208/s12249-021-01954-7

    Wael A. Mahdi, Afzal Hussain, Mohd Ramzan, Abdul Faruk… in AAPS PharmSciTech (2021)

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    Article

    Pluronic-Coated Biogenic Gold Nanoparticles for Colon Delivery of 5-Fluorouracil: In vitro and Ex vivo Studies

    The aim of the study was to prepare 5-fluorouracil (5-FU)-loaded biogenic gold nanoparticles with pluronic-based coating (PFGNPs), their optimization (full factorial predicted OBPN-1) and in vitro-ex vivo evaluat...

    Wael A. Mahdi, Afzal Hussain, Mohd Ramzan, Abdul Faruk… in AAPS PharmSciTech (2021)