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  1. No Access

    Article

    Recombinant DNA vaccines protect against tumors that are resistant to recombinant vaccinia vaccines containing the same gene

    Antigen-specific cancer immunotherapy involves the delivery of tumor-associated antigen to the host for the generation of tumor-specific immune responses and antitumor effects. We hypothesized that different d...

    C-H Chen, T-L Wang, H Ji, C-F Hung, DM Pardoll, W-F Cheng, M Ling, T-C Wu in Gene Therapy (2001)

  2. No Access

    Article

    Enhancement of suicidal DNA vaccine potency by linking Mycobacterium tuberculosis heat shock protein 70 to an antigen

    Naked DNA vaccines represent an attractive approach for generating antigen-specific immunity because of their stability and simplicity of delivery. There are particular concerns with DNA vaccines however, such...

    K-F Hsu, C-F Hung, W-F Cheng, L He, LA Slater, M Ling, T-C Wu in Gene Therapy (2001)

  3. No Access

    Article

    CD8+ T cells, NK cells and IFN-γ are important for control of tumor with downregulated MHC class I expression by DNA vaccination

    One of the major hurdles facing cancer immunotherapy is that cancers may downregulate expression of MHC class I molecules. The development of a suitable tumor model with downregulated MHC class I expression is...

    W F Cheng, C F Hung, K Y Lin, M Ling, J Juang, L He, C T Lin, T-C Wu in Gene Therapy (2003)

  4. No Access

    Article

    Connective tissue growth factor linked to the E7 tumor antigen generates potent antitumor immune responses mediated by an antiapoptotic mechanism

    A novel method for generating an antigen-specific cancer vaccine and immunotherapy has emerged using a DNA vaccine. However, antigen-presenting cells (APCs) have a limited life span, which hinders their long-t...

    W-F Cheng, M-C Chang, W-Z Sun, C-N Lee, H-W Lin, Y-N Su, C-Y Hsieh… in Gene Therapy (2008)

  5. No Access

    Article

    Noncarrier naked antigen-specific DNA vaccine generates potent antigen-specific immunologic responses and antitumor effects

    Genetic immunization strategies have largely focused on the use of plasmid DNA with a gene gun. However, there remains a clear need to further improve the efficiency, safety, and cost of potential DNA vaccines...

    C-A Chen, M-C Chang, W-Z Sun, Y-L Chen, Y-C Chiang, C-Y Hsieh, S M Chen… in Gene Therapy (2009)

  6. No Access

    Article

    Mesothelin-specific cell-based vaccine generates antigen-specific immunity and potent antitumor effects by combining with IL-12 immunomodulator

    Ovarian cancer is a gynecologic malignancy with a high mortality rate. In the present study, we developed a novel cell-based vaccine, Meso-VAX, to generate mesothelin antigen-specific immune responses and immu...

    M-C Chang, Y-L Chen, Y-C Chiang, T-C Chen, Y-C Tang, C-A Chen, W-Z Sun… in Gene Therapy (2016)