10 Result(s)

Chapter

Quantitative Isothermal Molecular Amplification Techniques

The amplification of DNA and RNA can be performed at isothermal conditions with both target and signal amplification techniques. These methods are also developed in a high-throughput format. In the past, compa...

H. G. M. Niesters, W. B. van Leeuwen in Molecular Diagnostics (2019)

Chapter

Quality Assurance, Management and Control in Molecular Diagnostics

Molecular diagnostics can and should only be applied in patient care when an extensive package of quality criteria is met. This applies to both the technical quality (an assay which identifies the appropriate ...

E. van Pelt-Verkuil, W. B. van Leeuwen in Molecular Diagnostics (2019)

Article

Antimicrobial susceptibility testing of Gram-positive and -negative bacterial isolates directly from spiked blood culture media with Raman spectroscopy

Patients suffering from bacterial bloodstream infections have an increased risk of develo** systematic inflammatory response syndrome (SIRS), which can result in rapid deterioration of the patients’ health. ...

H. E. Dekter, C. C. Orelio, M. C. Morsink… in European Journal of Clinical Microbiology … (2017)

Article

Discrimination of Aspergillus lentulus from Aspergillus fumigatus by Raman spectroscopy and MALDI-TOF MS

In 2005, a new sibling species of Aspergillus fumigatus was discovered: Aspergillus lentulus. Both species can cause invasive fungal disease in immune-compromised patients. The species are morphologically very si...

P. E. B. Verwer, W. B. van Leeuwen… in European Journal of Clinical Microbiology … (2014)

Article

Distribution, antibiotic susceptibility and tolerance of bacterial isolates in culture-positive cases of endocarditis in The Netherlands

During a two-year period data were collected nationwide in The Netherlands on 438 episodes of bacterial endocarditis (BE) in 432 patients. Of the strains isolated in these patients 419 were available for analy...

J. T. M. van der Meer, W. van Vianen, E. Hu… in European Journal of Clinical Microbiology … (1991)

Article

Degree and stability of tolerance to penicillin inStreptococcus pyogenes

The degree of antibiotic tolerance may be assessed by determining the tolerance percentage of a bacterial strain, defined as the surviving fraction of an inoculum that has been exposed for 24 hours to a high c...

M. F. Michel, W. B. van Leeuwen in European Journal of Clinical Microbiology … (1989)

Article

Quality control of aminoglycoside assays using an enzyme immunoassay and a polarization fluoro-immunoassay

J. E. Degener, W. B. van Leeuwen, J. A. van Noort, M. F. Michel in Antonie van Leeuwenhoek (1985)

Article

Efficacy of antimicrobial therapy in experimental listeriosis in normal mice and mice with impaired T-cell-mediated immunity

Irma A. J. M. Bakker-Woudenberg, W. B. van Leeuwen, M. F. Michel in Antonie van Leeuwenhoek (1981)