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Open AccessModifiable Risk Factors for Accelerated Decline in Processing Speed: Results from Three Dutch Population Cohorts
Several lifestyle, cardiovascular and psychosocial factors are associated with risk of cognitive decline and dementia. We studied the independent associations of a broad set of modifiable risk factors with dec...
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Article
Open AccessPerspectives of older women in the Netherlands: identifying motivators and barriers for healthy lifestyles and determinants of healthy aging
Women have a higher life expectancy than men but experience more years with physical disabilities in daily life at older ages, especially women with a migration background. This pinpoints older women as an imp...
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Article
The Association Between BMI and Different Frailty Domains: A U-Shaped Curve?
Previous studies showed a U-shaped association between BMI and (physical) frailty. We studied the association between BMI and physical, cognitive, psychological, and social frailty. Furthermore, the overlap be...
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Article
Open AccessTrajectories of metabolic risk factors and biochemical markers prior to the onset of type 2 diabetes: the population-based longitudinal Doetinchem study
Risk factors often develop at young age and are maintained over time, but it is not fully understood how risk factors develop over time preceding type 2 diabetes. We examined how levels and trajectories of met...
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Open AccessBack to the basics of ovarian aging: a population-based study on longitudinal anti-Müllerian hormone decline
Anti-Müllerian hormone (AMH) is currently used as an ovarian reserve marker for individualized fertility counseling, but very little is known of individual AMH decline in women. This study assessed whether the...
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Article
Open AccessTrends in risk factors for coronary heart disease in the Netherlands
Favourable trends in risk factor levels in the general population may partly explain the decline in coronary heart disease (CHD) morbidity and mortality. Our aim was to present long-term national trends in est...
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Article
Cardiovascular risk management of hypertension and hypercholesterolaemia in the Netherlands: from unifactorial to multifactorial approach
About 30 years ago, the first Dutch unifactorial guidelines on hypertension and hypercholesterolaemia were developed. These guidelines have been revised several times, often after publication of landmark studi...
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Article
Raw and processed fruit and vegetable consumption and 10-year stroke incidence in a population-based cohort study in the Netherlands
Prospective cohort studies have shown that high fruit and vegetable consumption is related to a lower risk of stroke. Whether food processing affects this association is unknown. We evaluated the associations ...
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Article
Awareness of hypertension: will it bring about a healthy lifestyle?
Guidelines for cardiovascular disease prevention recommend a non-pharmacological approach to reduce cardiovascular risk in those with elevated blood pressure. We assessed guideline adherence in hypertensives. ...
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Relation between body mass index, physical inactivity and use of prescription drugs: the Doetinchem Cohort Study
Obesity and physical inactivity are associated with several diseases such as diabetes, cardiovascular diseases, musculoskeletal complaints, osteoporosis, certain types of cancer and depression. However, few da...
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Article
Open AccessWeight change over five-year periods and number of components of the metabolic syndrome in a Dutch cohort
Overweight and obesity are associated with the metabolic syndrome (MetS). We studied the association of weight change over three consecutive 5-year periods with the number of MetS components in people aged 20–...
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Article
Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study
As nuclear receptors and transcription factors have an important regulatory function in adipocyte differentiation and fat storage, genetic variation in these key regulators and downstream pathways may be invol...
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Genetic variation in the renin-angiotensin system modifies the beneficial effects of ACE inhibitors on the risk of diabetes mellitus among hypertensives
The aim of this study was to assess whether the association between angiotensin-converting enzyme (ACE) inhibitor use and the incidence of treated diabetes mellitus is modified by genetic polymorphisms in the ...
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Interactions between five candidate genes and antihypertensive drug therapy on blood pressure
Despite the availability of effective antihypertensive drugs, there is a large variation in response to these drugs. This study investigates whether polymorphisms in the angiotensin converting enzyme (I/D), an...
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Prevalences of hyperhomocysteinemia, unfavorable cholesterol profile and hypertension in European populations
Hyperhomocysteinemia (HHCY) is a risk factor for cardiovascular diseases (CVD). HHCY may interact with hypertension (HTEN) and an unfavorable cholesterol profile (UNFAVCHOL) to alter the risk of CVD.
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Prevalence and determinants of undertreatment of hypertension in the Netherlands
The objective of this study was to determine the prevalence, treatment, and control of hypertension, and the determinants of undertreatment in the Dutch population. The study design was cross-sectional. A popu...
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Working group on epidemiology & prevention of the european society of cardiology
